CAS: 1229247-71-5; Tert-Butyl 4-((2-Bromo-5,5-Dimethylcyclohex-1-Enyl)Methyl)Piperazine-1-Carboxylate

英文名称Tert-Butyl 4-((2-Bromo-5,5-Dimethylcyclohex-1-Enyl)Methyl)Piperazine-1-Carboxylate
中文名称ABT-199中间体
IUPAC名称tert-butyl 4-((2-bromo-5,5-dimethylcyclohex-1-en-1-yl)methyl)piperazine-1-carboxylate
其它别名Tert-Butyl 4-((2-Bromo-5,5-Dimethylcyclohex-1-Enyl)Methyl)Piperazine-1-Carboxylate; 1-Piperazinecarboxylic Acid, 4-[(2-Bromo-5,5-Dimethyl-1-Cyclohexen-1-yl)Methyl]-, 1,1-Dimethylethyl Ester; 4-(2-Bromo-5,5-Dimethyl-Cyclohex-1-Enylmethyl)-Piperazine-1-Carboxylic Acid Tert- Butyl Ester
CAS编号1229247-71-5
MFCD编号:MFCD25509445
分子式:C18H31BrN2O2分子量:387.36
产品CID: 332342
产品分类有机原料 → 有机杂环化合物 → 二嗪烷类

相似结构搜索
InChIKey: RTIZUSLYTHVTQK-UHFFFAOYSA-N
InChI=1S/C18H31BrN2O2/c1-17(2,3)23-16(22)21-10-8-20(9-11-21)13-14-12-18(4,5)7-6-15(14)19/h6-13H2,1-5H3
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数4.0

物理性质

LogP:3.4

MSDS等安全信息

合成工艺路线路线简述

📜2-溴-5,5-二甲基-1-环己烯-1-甲醛,N-Boc-哌嗪置于溶剂黄146,三乙酰氧基硼氢化钠体系中,用二氯甲烷用作溶剂,化学反应 17.0H,以73%的收率获得abt-199中间体
参考文献: Compounds For Treating Cancer[fr] Composés Utilisés Pour Traiter Le Cancer
标题: Compounds For Treating Cancer[fr] Composés Utilisés Pour Traiter Le Cancer
摘要:通式(i)的化合物:其中r1,R2,R3,R4,R5,R6,X和y如本文所定义,是bcl-2的抑制剂,可用于治疗以异常细胞生长和/或失调凋亡为特征的疾病.