专利号:EP-1220823-B1 优先权日:1999-09-30 标题:Process for the synthesis of 2-hydroxyphenyl alkyl ketones 发明人:BORZATTA VALERIO; POLUZZI ELISA; VACCARI ANGELO 权利人:ENDURA SPA 摘要:A process is described for the synthesis of 2-hydroxyphenylalkyl ketones, by means of catalytic rearrangement of phenolic esters. This process is characterized by the use, as catalysts, of crystalline aluminosilicates of the pentasyl type having predefined values of silica/alumina ratio, grain size, surface area and porosity, and containing between 10 wt% and 40 wt% of finely ground alumina as bonding agent. The rearrangement thus catalyzed involves a high conversion of the phenolic ester, a high orthoselectivity and a low formation of phenolic by-products, thus enabling the formation of the end product in high yields. In particular, the process applies to the synthesis of 2-hydroxyacetophenone.
专利号:US-9376461-B2 优先权日:2011-06-06 标 题:Non-enzymatic synthesis of O-acetyl-ADP-ribose and analogues thereof 发明人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B 权利人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B; GLAXOSMITHKLINE LLC 摘要:Provided herein is a simple, one-step, non-enzymatic synthesis of O-Acetyl-ADP-ribose (OAADPR) from NAD and sodium acetate in acetic acid. The extension of this reaction to other carboxylic acids, demonstrates that the reaction between NAD, and NAD analogs produces mixtures of the corresponding 2′- and 3′-carboxylic esters. Included are O-carboxyl-ADP-ribose compounds and corresponding methods of synthesis (e.g., O-propionyl-ADP-ribose, O-succinyl-ADP-ribose, O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds.
专利号:US-7943594-B2 优先权日:2002-07-10 标 题 :Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans 发明人:SEEBERGER PETER H; HEWITT MICHAEL C; SNYDER DANIEL A 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for GPI assembly. Yet another aspect of the invention relates to an automated method for the synthesis of GPIs and fragments thereof.
专利号:US-4841045-A 优先权日:1985-03-12 标 题 :Synthesis of vinblastine and vincristine type compounds 发明人:KUEHNE MARTIN 权利人:UNIV VERMONT 摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.
专利号:US-4897477-A 优先权日:1985-03-12 标题:Synthesis of vinblastine and vincristine type compounds 发明人:KUEHNE MARTIN 权利人:UNIV VERMONT 摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.
专利号:US-4140708-A 优先权日:1975-10-16 标 题 :Asymmetric synthesis of optically active prostaglandins 发明人:CHADHA NARESH K; PARTRIDGE JR JOHN J; USKOKOVIC MILAN R 权利人:HOFFMANN LA ROCHE 摘要:An asymmetric synthesis of optically active prostaglandin F 2 α from cyclopentadiene including intermediates in this synthesis.
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