CAS: 118325-22-7; (2S,3S,4S,5R,6R)-6-(((2R,3R,4S,5S,6S)-6-Carboxy-2-(((3S,4Ar,6Ar,6Bs,8As,11S,12Ar,14Ar,14Bs)-4,4,6A,6B,8A,11,14B-Heptamethyl-14-Oxo-11-((((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Carbonyl)-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,14,14A,14B-Icosahydropicen-3-yl)Oxy)-4,5-Dihydroxytetrahydro-2H-Pyran-3-yl)Oxy)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Carboxylic Acid
该化合物是一种来自Glycyrrhiza物种根部的三叶寄生虫,特别是可通称为甘油的甘油,其特点是结构复杂,包括类丙酮和甘糖,形成其非生殖性.Licoricesaponin A3展示了各种生物活动,包括抗炎,抗氧化剂和潜在的抗癌特性,这使药理研究感兴趣.其行动机制往往涉及调控信号路径和与细胞膜的相互作用,这可以影响细胞过程.此外,还研究了其对免疫系统的影响及其提高其他治疗剂生物利用率的潜力.通常使用高性液相色学(HPLC)和大规模光谱测量等技术对化合物进行分析,以确定其在各种配方中的纯度和浓度.
- 英文名称(2S,3S,4S,5R,6R)-6-(((2R,3R,4S,5S,6S)-6-Carboxy-2-(((3S,4Ar,6Ar,6Bs,8As,11S,12Ar,14Ar,14Bs)-4,4,6A,6B,8A,11,14B-Heptamethyl-14-Oxo-11-((((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Carbonyl)-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,14,14A,14B-Icosahydropicen-3-yl)Oxy)-4,5-Dihydroxytetrahydro-2H-Pyran-3-yl)Oxy)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Carboxylic Acid
- 中文名称甘草皂苷A3
- IUPAC名称(2S,3S,4S,5R,6R)-6-(((2R,3R,4S,5S,6S)-6-carboxy-2-(((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-11-((((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
- 其它别名Licoricesaponin A3; Liquorice-Saponin A3; β-D-Glucopyranosiduronic Acid, (3β,20β)-29-(β-D-Glucopyranosyloxy)-11,29-Dioxoolean-12-En-3-Yl 2-O-β-D-Glucopyranuronosyl-
- CAS编号118325-22-7
- MFCD编号:MFCD32197420
- FDA UNII编号:88G00OJY89
- 分子式:C48H72O21分子量:985.08
- 产品CID: 234036
- 产品分类生物化工 → 提取物 → 植物提取物
物理性质
MSDS等安全信息
上下游产品
50H76O21C50H76O2150H76O21C50H76O21 glycyrrhizin methyl beta-D-glucopyranoside methyl β-D-glucopyranosiduronic acid合成工艺路线路线简述
📜在 甲醇,Sodium Methylate,水,Sodium Hydroxide体系中,用 甲醇 用作溶剂,化学反应 2.0H,以72%的收率获得甘草皂苷a3
参考文献:Mannosylated Saponins Based On Oleanolic And Glycyrrhizic Acids. Towards Synthetic Colloidal Antigen Delivery Systems
标题:Mannosylated Saponins Based On Oleanolic And Glycyrrhizic Acids. Towards Synthetic Colloidal Antigen Delivery Systems
摘要:Immunostimulatory Saponin Based Colloidal Antigen Delivery Systems Show Promise As Adjuvants For Subunit Vaccines. For This Reason,Allyl Oleanolate Was Glycosylated At The 3-Position Using Trichloroacetimidate Donors To Give Monodesmodic Saponins Following Deprotection. Bisdesmodic Saponins Were Synthesized By Double Glycosylation At The 3-And 28-Positions Of Oleanolic Acid. When Formulated Together With Cholesterol And Phospholipids,Ring-Like,Helical And Rod-Like Nanostructures Were Formed Depending On The Saponin Concentrations Used. As An Indication Of Adjuvant Activity,The Ability Of These Formulations,And The Saponins By Themselves,To Induce Dendritic Cell Maturation Was Measured,But No Significant Activity Was Observed. (C) 2009 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2009.05.043
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905310000-1,2-乙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Kitagawa I, Hori K, Taniyama T, Zhou JL, Yoshikawa M. Saponin and sapogenol. XLVII. On the constituents of the roots of Glycyrrhiza uralensis Fischer from northeastern China. (1). Licorice-saponins A3, B2, and C2. Chem Pharm Bull (Tokyo). 1993 Jan;41(1):43-9. doi: 10.1002/jssc.201300410. Epub 2013 Aug 21.
合成参考文献
参考文献:10.1248/cpb.41.43
摘要:Kitagawa I, Hori K, Taniyama T, Zhou JL, Yoshikawa M. Saponin and sapogenol. XLVII. On the constituents of the roots of Glycyrrhiza uralensis Fischer from northeastern China. (1). Licorice-saponins A3, B2, and C2. Chem Pharm Bull (Tokyo). 1993 Jan;41(1):43–9. doi: 10.1248/cpb.41.43.
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