己二酸置于hydrazine Hydrate,硫酸体系中,用 甲醇 用作溶剂,化学反应 24.0H,反应生成己二酸二酰肼 参考文献:Cd2+ 诱导的荧光金属凝胶:以 Chef 和 Acq 现象为例 标题:Cd2+ 诱导的荧光金属凝胶:以 Chef 和 Acq 现象为例 摘要:已经报道了用于合成基于 Cd 2+配位的荧光金属凝胶的己二酸衍生配体h 2 Al .凝胶化过程中涉及三种荧光现象,即螯合增强荧光(chef),聚集引起的猝灭(acq)和聚集诱导发射(aie). Doi:10.1002/asia.201900559
专利信息
专利号:US-2024024489-A1 优先权日:2020-11-20 标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof 发明人:MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE 权利人:PASTEUR INSTITUT 摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)
专利号:US-6262251-B1 优先权日:1995-10-19 标题 :Method for solution phase synthesis of oligonucleotides 发明人:PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING 权利人:PROLIGO LLC 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.
专利号:WO-9847910-A1 优先权日:1997-04-21 标题:Method for solution phase synthesis of oligonucleotides 发明人:PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S 权利人:NEXSTAR PHARMACEUTICALS INC; PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.
专利号:US-5874532-A 优先权日:1997-01-08 标 题 :Method for solution phase synthesis of oligonucleotides and peptides 发明人:PIEKEN WOLFGANG; GOLD LARRY 权利人:NEXSTAR PHARMACEUTICALS INC 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.
专利号:US-6001966-A 优先权日:1995-10-19 标题 :Method for solution phase synthesis of oligonucleotides and peptides 发明人:PIEKEN WOLFGANG; GOLD LARRY 权利人:PROLIGO LLC 摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.
专利号:US-2024262834-A1 优先权日:2021-05-28 标 题:Synthesis of btk inhibitor and intermediates thereof 发明人:CHEN YONGGANG; CORRY JAMES; DESMOND RICHARD; DI MASO MICHAEL J; FORSTATER JACOB H; KUETHE JEFFREY T; KUHL NADINE; LARSON REED; LEVESQUE FRANCOIS; NARSIMHAN KARTHIK; OTTE DOUGLAS; PRIER CHRISTOPHER K; SHEVLIN MICHAEL; SIROTA ERIC; TAN LUSHI; THAISRIVONGS DAVID A; TURNBULL BEN W H; WANG ZHIXUN; XIAO KAIJIONG 权利人:MERCK SHARP & DOHME LLC 摘要:The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt thereof, including the preparation of intermediates used to make Compound A or a pharmaceutically acceptable salt thereof.
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合成参考文献
摘要:Journal of the American College of Toxicology 13(3):154-156, 1994 参考文献:10.1007/s10719-011-9332-7 摘要:Cox AD, St Michael F, Cairns CM, Lacelle S, Filion AL, Neelamegan D, Wenzel CQ, Horan H, Richards JC. Investigating the potential of conserved inner core oligosaccharide regions of Moraxella catarrhalis lipopolysaccharide as vaccine antigens: accessibility and functional activity of monoclonal antibodies and glycoconjugate derived sera. Glycoconj J. 2011 May;28(3-4):165–82. doi: 10.1007/s10719-011-9332-7. 参考文献:10.1007/s00441-015-2298-1 摘要:Wen Y, Yu S, Wu Y, Ju R, Wang H, Liu Y, Wang Y, Xu Q. Spinal cord injury repair by implantation of structured hyaluronic acid scaffold with PLGA microspheres in the rat. Cell Tissue Res. 2016 Apr;364(1):17–28. doi: 10.1007/s00441-015-2298-1. 参考文献:10.1186/s13287-021-02662-6 摘要:Marofi F, Alexandrovna KI, Margiana R, Bahramali M, Suksatan W, Abdelbasset WK, Chupradit S, Nasimi M, Maashi MS. MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy. Stem Cell Research & Therapy. 2021 Dec 04;12(1):597. doi: 10.1186/s13287-021-02662-6.