CAS: 1071-36-9; Sodium 2-Cyanoacetate(White To Off-White)

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专利信息

专利号:WO-2013121018-A1
优先权日:2012-02-17
标题 :Synthesis of cyanocarboxylic acid alkyl esters
发明人：FRANZKE CONSTANZE; OTT LOTHAR; GRUETZNER THOMAS; LITZMANN OLIVER; REPKE JENS-UWE; HAMMANN MARKUS; LORENZ HILKE-MARIE; MEEMKEN FABIAN CARL INGOLD
权利人:LONZA AG
摘要:Provided is a process for obtaining a compound of formula (I): N≡C-CH 2 -A-C(O)-OR, wherein Hal is halogen selected from F, Cl, Br or I, A denotes a bond or a divalent spacer selected from alkylene and arylene groups, and R is a C 1-4 alkyl group, by reacting a compound of formula (II): Hal-CH 2 -A-C(O)-OR, wherein Hal is a halogen atom selected from F, Cl, Br and I, and wherein A and R are as defined above, with hydrogen cyanide in the presence of a first base, wherein the molar ratio between hydrogen cyanide and said first base is from 1:0.3 to 1:0.95 and the molar ratio between hydrogen cyanide to the compound of formula (II) is at least 1:1.

专利号:US-10112955-B2
优先权日:2015-10-29
标题 :Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
发明人：SPRENGELER PAUL A; REICH SIEGFRIED H; ERNST JUSTIN T; WEBBER STEPHEN E; SHAGHAFI MIKE; MURPHY DOUGLAS; TRAN CHINH
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds A 1 , A 2 , A 3 , A 4 , A 5 , W 1 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b , and R 10 and subscript “nâ€? are as defined in the specification. The inventive Formula I compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:CN-114790173-A
优先权日:2022-04-29
标题:Green synthesis process of 1-methyl-3-difluoromethylpyrazole-4-carboxylic acid

专利号:JP-S59148751-A
优先权日:1983-02-15
标题 :Synthesis method of cyanoacetate

专利号:CN-113402420-A
优先权日:2021-06-23
标题 :A kind of 2-amino, 2-cyanoacetic acid methyl ester/ethyl ester, 2-amino, 2-cyanoacetic acid and its synthesis process

专利号:CN-114790173-B
优先权日:2022-04-29
标 题 :Green Synthesis Process of 1-Methyl-3-Difluoromethylpyrazole-4-Carboxylic Acid