CAS: 1039307-95-3; (2R,4S)-5-([1,1'-Biphenyl]-4-Yl)-4-Amino-2-Methylpentanoic Acid

上下游产品

(4-biphenylyl)acetic acid 4-biphenylacetonitrile (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydr°Chloride -α-methyl-4-pentanoateα-ethyl (αR,γS)-γ-(3-carboxy-1-oxopropyl)amino-α-methyl1,1'-biphenyl-4-pentanoate

专利信息

专利号:US-10851059-B2
优先权日:2016-08-17
标题:Processes and intermediates for NEP inhibitor synthesis
发明人：KLEINBECK-RINIKER FLORIAN KARL; MAFLI IVES; MARTIN BENJAMIN; PENN GERHARD; SEDELMEIER GOTTFRIED; SEDELMEIER JOERG; VENTURONI FRANCESCO
权利人:NOVARTIS AG
摘要:The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

专利号:US-10385004-B2
优先权日:2015-02-13
标 题:Process and intermediates for the preparation of NEP inhibitors
发明人：MARTIN BENJAMIN; MANDRELLI FRANCESCA; VENTURONI FRANCESCO
权利人:NOVARTIS AG
摘要:The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

专利号:US-12297462-B2
优先权日:2017-06-14
标 题:Engineered transaminase polypeptides for industrial biocatalysis
发明人：NOVICK SCOTT J; DELLAS NIKKI; ALVIZO OSCAR; Garcia Ravi David; CHING CHARLENE; ENTWISTLE DAVID
权利人:CODEXIS INC
摘要:The present invention provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The invention also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.

专利号:CN-118109528-A
优先权日:2024-04-10
标题 :A method for biocatalytic synthesis of sacubitril intermediate (2R, 4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylvaleric acid

专利号:CN-118516422-A
优先权日:2024-04-10
标 题:A method for biocatalytic synthesis of sacubitril intermediates

专利号:US-11434192-B2
优先权日:2015-12-10
标 题:Process and intermediates
发明人：KLEINBECK-RINIKER FLORIAN KARL; MARTIN BENJAMIN; PENN GERHARD; VENTURONI FRANCESCO; SCHLAMA THIERRY; RUCH THOMAS; ALLMENDINGER THOMAS; WIETFELD BERNHARD; FILIPPONI PAOLO
权利人:NOVARTIS AG
摘要:The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.