CAS: 101990-73-2; 2-Chloro-4-(Chloromethyl)Pyridine

相似化合物

3678-62-4 39621-00-6 175204-45-2

上下游产品

CAS号100704-10-7 2-氯吡啶-4-甲醇 | CAS号3678-62-4 2-氯-4-甲基吡啶 | CAS号65287-34-5 2-氯吡啶-4-甲酰氯

2-氯吡啶-4-甲酰氯置于sodium Tetrahydroborate,氯化亚砜体系中,用 水,甲苯 用作溶剂,以43%的收率获得2-氯-4-(氯甲基)吡啶
参考文献:Synthesis And Biological Evaluation Of Indomethacin Analogs Possessing A N-Difluoromethyl-1,2-Dihydropyrid-2-One Ring System: A Search For Novel Cyclooxygenase And Lipoxygenase Inhibitors
标题:Synthesis And Biological Evaluation Of Indomethacin Analogs Possessing A N-Difluoromethyl-1,2-Dihydropyrid-2-One Ring System: A Search For Novel Cyclooxygenase And Lipoxygenase Inhibitors
摘要:A Novel Class Of Indomethacin Analogs Were Synthesized Wherein A N-Difluoromethyl-1,2-Dihydropyrid-2-One Moiety (5-Lox Pharmacophore) Was Attached At Its C-4 Or C-5 Position Via Either A C=o (14A-B) Or Ch2 (19A-B) Linker To The Indole N-1-Position. In This Regard,Replacement Of The 4-Chlorobenzoyl Group Present In Indomethacin By N-Difluoromethyl-1,2-Dihydropyrid-2-One-4-(Or 5-)Carbonyl And N-Difluoromethyl-1,2-Dihydropyrid-2-One-4-Yl(Or 5-yl)Methylene Moieties Furnished Compounds Showing No Inhibitory Activities Against The Cox-2/5-Lox Enzymes (Except For The Weak But Selective Cox-2 Inhibitor 19A,Cox-2 Ic50 = 31 Mu M),And Moderate In Vivo Anti-Inflammatory Activities (Except For The Methylene Compound 19A That Was Inactive). These Structure-Activity Data Indicate Replacement Of The 4-Chlorobenzoyl Group Present In Indomethacin By A N-Difluoromethyl-1,2-Dihydropyrid-2-One Ring System Connected By A C=o Or Ch2 Linker Is Not A Suitable Approach For The Design Of Dual Cox-2/5-Lox Inhibitory Analogs Of Indomethacin. (C) 2010 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2010.07.132

专利信息

专利号:US-9266848-B2
优先权日:2009-09-17
标题:4-alkoxy-N-(2-hydroxycarbamoyl-2-piperidinyl-ethyl)-benzamide compounds as selective TACE-inhibitors for the treatment of inflammatory diseases
发明人：CLARY LAURENCE; PASCAL JEAN-CLAUDE
权利人:CLARY LAURENCE; PASCAL JEAN-CLAUDE; GALDERMA RES & DEV
摘要:The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I) below: and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions.

专利号:CN-102304082-B
优先权日:2011-09-30
标 题 :Synthesis method of 2-chloro-4-(piperidylmethyl)pyridine