CAS: 8068-28-8; Colistin Methanesulfonate Sodium Salt
该化合物是一种主要用于治疗多抗药性抗菌菌感染的多元菌素抗生素,是一种在身体中转化成共产素的活性形式,它扰乱了细菌细胞膜,导致细胞死亡;科利斯特泰因特通常通过静脉注射或吸入进行,特别是在肺炎或血液感染的情况下;其活动范围包括多种病原体,如肺炎和鲍安尼病,但使用这种病原体往往受到潜在的...
- 英文名称Colistin Methanesulfonate Sodium Salt
- 中文名称粘杆菌素甲基磺酸钠
- IUPAC名称sodium (5S,8S,11S)-8-((R)-1-hydroxyethyl)-5-(((3S,6S,9S,12S,15R,18S,21S)-3-((R)-1-hydroxyethyl)-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris(2-((sulfonatomethyl)amino)ethyl)-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)carbamoyl)-11-((R)-6-methyloctanamido)-7,10-dioxo-2,6,9,14-tetraazapentadecane-1,15-disulfonate (5S,8S,11S)-8-((R)-1-hydroxyethyl)-5-(((3S,6S,9S,12S,15R,18S,21S)-3-((R)-1-hydroxyethyl)-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris(2-((sulfonatomethyl)amino)ethyl)-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)carbamoyl)-11-(6-methylheptanamido)-7,10-dioxo-2,6,9,14-tetraazapentadecane-1,15-disulfonate
- 其它别名COLIMYCIN SODIUM METHANESULFONATE; COLISTIN METHANESULFONATE SODIUM SALT; COLISTIN SODIUM METHANESULFONATE; (METHANESULFONIC ACID DERIVATIVE OF POLYMYXIN E) SODIUM SALT; POLYMYXIN E SODIUM METHANESULFONATE; colimycinm; colistinat; colistinmethanesulfonicacid,sodiumsalt
- CAS编号8068-28-8
- EINECS号:232-516-9
- 分子式:C45H85N13O10分子量:967.654236
- 产品CID: 1801922
- 产品分类化学试剂 → 有机试剂 → 磺酸盐/亚磺酸盐
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2912110000-甲醛
2912120000-乙醛
2921211000-乙二胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:JP-S5934197-B2
优先权日:1972-08-30
标题 :Synthesis of antibacterial agent intermediates
专利号:FR-2669643-A1
优先权日:1990-11-28
标 题:PROCESS FOR THE ENZYMATIC SYNTHESIS OF AMMONIUM ADIPATE
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
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主要参考文献
1: Conole D, Keating GM. Colistimethate sodium dry powder for inhalation: a review of its use in the treatment of chronic Pseudomonas aeruginosa infection in patients with cystic fibrosis. Drugs. 2014 Mar;74(3):377-87. doi: 10.1007/s40265-014-0181-0. 61(3):e02319-16. doi: 10.1128/AAC.02319-16.
3: Tappenden P, Harnan S, Uttley L, Mildred M, Carroll C, Cantrell A. Colistimethate sodium powder and tobramycin powder for inhalation for the treatment of chronic Pseudomonas aeruginosa lung infection in cystic fibrosis: systematic review and economic model. Health Technol Assess. 2013 Dec;17(56):v-xvii, 1-181. doi: 10.3310/hta17560.
4: Bialvaei AZ, Samadi Kafil H. Colistin, mechanisms and prevalence of resistance. Curr Med Res Opin. 2015 Apr;31(4):707-21. doi: 10.1185/03007995.2015.1018989. Epub 2015 Mar 19. 40(6):647-654. English, Spanish. doi: 10.1016/j.nefro.2020.04.007. Epub 2020 May 28. 74(11):3268-3273. doi: 10.1093/jac/dkz356.
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