CAS: 773-47-7; Dimethyl Benzylphosphonate

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CAS号100-39-0 溴化苄 | CAS号121-45-9 亚磷酸三甲酯 | CAS号100-44-7 氯化苄 | CAS号868-85-9 亚磷酸二甲酯 | CAS号100-52-7 苯甲醛 | CAS号1666-17-7 苯甲醛对甲苯磺酰腙 | CAS号119-61-9 二苯甲酮 | CAS号86000-93-3 [dimethoxyphosp... | CAS号56153-57-2 benzyl dimethyl... | CAS号911-45-5 氯米芬 | CAS号886-65-7 1,4-二苯基1,3-丁二烯 | CAS号833-81-8 (E)-丙-1-烯-1,2-二基二苯 | CAS号779-51-1 Alpha－甲基均二苯乙烯 | CAS号58-72-0 三苯乙烯 | CAS号6881-57-8 苄基磷酸 | CAS号616-39-7 N,N-二乙基甲胺 | CAS号16965-75-6 [chloro(dimetho... | CAS号1499-19-0 BENZYLPHOSPHONI... | CAS号18406-56-9 Bis(trimethylsi...

📜Benzyl Dimethyl Phosphite置于磷酸三丁酯体系中,用 环己烷 作为反应溶剂,化学反应生成 苯甲基膦酸二甲酯
参考文献:二甲基苄基和二甲基对乙酰基苄基亚磷酸酯的 Photo-Arbuzov 重排
标题:二甲基苄基和二甲基对乙酰基苄基亚磷酸酯的 Photo-Arbuzov 重排
摘要:在乙腈,环己烷和苯中研究了二甲基亚磷酸苄酯 (1) 和二甲基对乙酰苄基亚磷酸酯 (8) 的直接紫外线照射.亚磷酸盐 1 主要产生光-Arbuzov 产物,苄基膦酸二甲酯 (2),基于消耗的亚磷酸盐,以及少量的联苄 (20) 和亚磷酸二甲酯 (10),产率为 67-81%.在环己烷中形成 2 的量子产率 φp 为 0.43.相比之下,亚磷酸酯 8 的辐照仅产生 7-13% 的光-Arbuzov 膦酸酯 (9),但产生相对大量的自由基扩散产物:亚磷酸二甲酯 (10) 对乙酰苄基自由基二聚体 (11);和对乙酰基甲苯 (12).显然,与苯乙酮密切相关的 8 主要通过三重态激发态发生反应,反应生成长寿命的三重态,自由基对(6 和 7A).在苯中,进一步的产物(15,16,17A 和 17B)被确定为由膦酰基自由基 (6) 加成到苯得到环己二烯基...
DOI:10.1021/ja982440K

专利信息

专利号:US-5420328-A
优先权日:1992-09-11
标题:Methods for the synthesis of phosphonate esters
发明人：CAMPBELL DAVID A
权利人:AFFYMAX TECH NV
摘要:Phsophonate esters can be synthesized in high yields by condensations of alcohols with methyl phosphonates followed by selective demethylation. The reaction is general, relativly insensitive to steric constraints of hindered phosphonic acids, and can also be carried out on a solid support to synthesize large collections of compounds to screen for pharmacological activity.

专利号:US-5359115-A
优先权日:1992-03-26
标题 :Methods for the synthesis of phosphonate esters
发明人：CAMPBELL DAVID A; JACOBS JEFFREY W
权利人:AFFYMAX TECH NV
摘要:Phosphonate esters can be synthesized in high yields by condensations of alcohols with methyl phosphonates followed by selective demethylation. The reaction is general, relatively insensitive to steric constraints of hindered phosphonic acids, and can also be carried out on a solid support to synthesize large collections of compounds to screen for pharmacological activity.

专利号:US-7709465-B2
优先权日:2006-05-19
标 题:Phosphorous containing compounds including triphenylmethylphosphonate esters for the treatment of melanoma and other cancers
发明人：HERGENROTHER PAUL J; NESTERENKO VITALIY; PUTT KARSON S; PALCHAUDHURI RAHUL
权利人:UNIV ILLINOIS
摘要:Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. Particularly disclosed are phosphonate esters. Compounds, methods of making the compounds, medicaments and method of manufacture of medicaments and therapeutic methods with applications against cancer including breast cancer, melanoma, colon cancer, leukemia and lymphoma, and other cancer cells are described.

专利号:WO-2025133100-A1
优先权日:2023-12-22
标 题:Process for the preparation of intermediates useful for the preparation of tapinarof
发明人：MARQUILLAS OLONDRIZ FRANCISCO DE ASÃ?S; LEÓN SERRANO THIERRY
权利人:INTERQUIM SA
摘要:The present invention relates to a new process for the preparation of synthesis intermediate products useful for the preparation of tapinarof and to new intermediates thus obtained.

专利号:EP-0659188-A1
优先权日:1992-09-11
标 题:Methods for the synthesis of phosphonate esters

专利号:EP-0659188-A4
优先权日:1992-09-11
标题:METHODS OF SYNTHESIS OF PHOSPHONATE ESTERS.