CAS: 767-01-1; 2-(Chloromethyl)-5-Methylpyridine

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CAS号22940-71-2 5-甲基-吡啶-2-基)甲醇 | CAS号4986-05-4 2,5-二甲基吡啶氮氧化物 | CAS号772-71-4 2-acetoxymethyl... | CAS号589-93-5 2,5-二甲基吡啶 | CAS号5552-82-9 ethyl 2-(5-meth...

📜2-Acetoxymethyl-5-Methyl Pyridine置于sodium Hydroxide,氯化亚砜体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 4.0H,反应生成 2-(氯甲基)-5-甲基吡啶
参考文献:2-[((2-吡啶基甲基)亚磺酰基]-1H-噻吩并[3,4-D]咪唑.一类新型的胃h + / K(+)-Atpase抑制剂.
标题:2-[((2-吡啶基甲基)亚磺酰基]-1H-噻吩并[3,4-D]咪唑.一类新型的胃h + / K(+)-Atpase抑制剂.
摘要:合成2-[((2-吡啶基甲基)亚磺酰基]噻吩并咪唑类化合物,并研究其作为胃h + / K(+)-Atpase的潜在抑制剂.已发现两种可能的噻吩并咪唑系列的[3,4-D]异构体在体外和体内都是有效的胃酸分泌抑制剂.结构活性关系表明,特别是在吡啶部分的4位具有额外的电子要求特性的亲脂性烷氧基,苄氧基和苯氧基取代基与未取代的噻吩并[3,4-D]咪唑结合会导致具有高活性的化合物.非常好的化学稳定性.噻吩并[3,4-D]咪唑部分的各种取代方式导致较低的生物活性.选择了七氟丁氧基衍生物萨维拉唑(hoe 731,5D)进行进一步开发,目前正在临床评估中.
DOI:10.1021/jm00081A004

专利信息

专利号:US-2014303333-A1
优先权日:2011-10-14
标题:Iron bisphenolate complexes and methods of use and synthesis thereof
发明人：SHAVER MICHAEL P; KOZAK CHRISTOPHER M
权利人:UNIV PRINCE EDWARD ISLAND; GENESIS GROUP INC
摘要:The present application, relates to iron bisphenolate complexes and methods of use and synthesis thereof. The iron complexes are prepared from tridentate or tetradentate ligands of Formula I: wherein R 1 and R 2 are as defined herein. Also provided are methods and processes of using the iron bisphenolate complexes as catalysts in cross-coupling reactions and in controlled radical polymerizations.

专利号:US-7300639-B2
优先权日:2002-12-03
标 题:Process for removing metals from liquids
发明人：LIU WANSHENG
权利人:BRISTOL MYERS SQUIBB CO
摘要:A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , HET, and X-Z are as described herein, which process comprising the step of removing one or more metals from a solution of the compound of formula I or an intermediate or precursor thereof. The processes for removing metal comprise the step of contacting the liquid with a solid extractant comprising a metal-binding functionality.

专利号:US-2023192718-A1
优先权日:2018-03-30
标 题 :Bicyclic enone carboxylates as modulators of transporters and uses thereof
发明人：SANDANAYAKA VINCENT
权利人:NIROGY THERAPEUTICS INC
摘要:The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

专利号:US-7576245-B2
优先权日:2002-07-11
标题:Fluorous tagging and scavenging reactants and methods of synthesis and use thereof
发明人：ZHANG WEI; LUO ZHIYONG
权利人:FLUOROUS TECHNOLOGIES INC
摘要:The present invention includes methods and compositions for increasing the fluorous nature of an organic compound by reacting it with at least one fluorous compound to produce a fluorous tagged organic compound. The increased fluorous nature of the fluorous tagged organic compound can then be utilized to separate the fluorous organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom. The resultant fluorous tagged organic compound can be subjected to subsequent chemical transformations, wherein the fluorous nature of the tagged compound is utilized to increase the ease of separation of the fluorous tagged organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom, after each chemical transformation. The chemical transformations result in a second fluorous tagged organic compound wherein the fluorous nature of the second fluorous tagged organic compound can then be reduced by removing the fluorous group therefrom, thereby producing a second organic compound that may be employed as a pharmaceutical compound or intermediate, or a combinatorial library component.

专利号:US-6603000-B2
优先权日:2001-07-11
标题:Synthesis for heteroarylamine compounds
发明人：YEE NATHAN; KAPADIA SURESH R; SONG JINHUA J
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed is a novel method of producing heteroaryl amines of the formula(I): n wherein X, Y and Z are described herein, the heteroarylamines are useful in the production of heteroaryl ureas which are key component in pharmaceutically active compounds possessing a heteroaryl urea group.

专利号:US-8916705-B2
优先权日:2011-10-14
标 题:Procaspase-activating compounds and compositions
发明人：HERGENROTHER PAUL J
权利人:UNIV ILLINOIS; TRUSTEES OF THE UNIVERSITY OF ILLILNOIS BOARD OF
摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.