CAS: 6926-08-5; (1S,4As,5R,7S)-7-Methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-5,6,7,7A-Tetrahydrocyclopenta[c]Pyran-4A,5,7(1H)-Triol
该化合物是一种自然形成的类状藻,主要存在于植物Harpagophytum procentbens的根部,通常被称为魔鬼的爪子.这种化合物的特点是其苦味,以其潜在的抗炎和止痛特性而著称,使其对草药和饮食补充物具有兴趣.Harpagide经常因其对关节炎和其他炎症等条件的影响而受到研究.磷酸盐的化学结构包括一个环开胃环,它典型地是一种类状,通常以胶质为形式存在,意思是它与糖分子捆绑在一起.它的药理活动归因于它能够调节各种生物化学途径,尽管确切的机制仍在调查之中. 通常认为它使用得当适当时是安全的,但和所有草药化合物一样,它可能与其他药物相互作用,并且应当谨慎使用.
- 英文名称(1S,4As,5R,7S)-7-Methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-5,6,7,7A-Tetrahydrocyclopenta[c]Pyran-4A,5,7(1H)-Triol
- 中文名称哈巴苷
- IUPAC名称(1S,4aS,5R,7S)-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5,6,7,7a-tetrahydrocyclopenta[c]pyran-4a,5,7(1H)-triol
- 其它别名(1S-(1a,4aa,5a,7a,7a))-1,4a,5,6,7,7a-Hexahydro-4a,5,7-trihydroxy-7-methylcyclopenta[c]pyran-1-yl beta-D-glucopyranoside
- CAS编号6926-08-5
- MFCD编号:MFCD00017306
- EINECS号:230-050-0
- FDA UNII编号:OF59XHX7SR
- 分子式:C15H24O10分子量:364.35
- 产品CID: 2334262
- 产品分类生物化工 → 提取物
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号87686-74-6 8-p-coumaroyl-h...合成工艺路线路线简述
📜8-O-肉桂酰哈巴苷置于sodium Hydroxide体系中,化学反应生成 哈巴苷
参考文献:Kikuchi,Tohru; Matsuda,Satoko; Kubo,Yoko,Chemical And Pharmaceutical Bulletin,1983,Vol. 31,# 7,P. 2296-2301
标题:Kikuchi,Tohru; Matsuda,Satoko; Kubo,Yoko,Chemical And Pharmaceutical Bulletin,1983,Vol. 31,# 7,P. 2296-2301
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6280737-B1
优先权日:1996-03-21
标 题 :Harpagoside-enriched extract from harpagophytum procumbens and processes for producing same
发明人：STUMPF KARL-HEINZ; JAGGY HERMANN; OSCHMANN RAINER; KOCH EGON; SIMMET THOMAS
权利人:SCHWABE WILLMAR GMBH & CO
摘要:The disclosure relates to extracts from Harpagophytum procumbens with a high harpagoside content, to processes for producing them, such extracts containing no components capable of stimulating the synthesis of thromboxane B2 and cysteinylleucotrienes, and to pharmaceutical compositions containing such extracts.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Erukainure OL, Atolani O, Muhammad A, Katsayal SB, Ebhuoma OO, Ibeji CU, Mesaik MA. Targeting the initiation and termination codons of SARS-CoV-2 spike protein as possible therapy against COVID-19: the role of novel harpagide 5-O-β- D-glucopyranoside from Clerodendrum volubile P Beauv. (Labiatae). J Biomol Struct Dyn. 2020 Nov
3:1-14. doi: 10.1080/07391102.2020.1840439. Epub ahead of print.
2: Frezza C, de Vita D, Toniolo C, Ventrone A, Tomassini L, Foddai S, Nicoletti M, Guiso M, Bianco A, Serafini M. Harpagide: Occurrence in plants and biological activities - A review. Fitoterapia. 2020 Nov;147:104764. doi: 10.1016/j.fitote.2020.104764. Epub 2020 Oct 26. 21(12):979-993. doi: 10.2174/1567201817666200731170731.
合成参考文献
参考文献:10.1111/j.2042-7158.2010.01235.x
摘要:Modarai M, Suter A, Kortenkamp A, Heinrich M. The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations. J Pharm Pharmacol. 2011 Mar;63(3):429–38. doi: 10.1111/j.2042-7158.2010.01235.x.
参考文献:10.1016/j.bmc.2011.06.069
摘要:Zhang L, Feng L, Jia Q, Xu J, Wang R, Wang Z, Wu Y, Li Y. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Bioorg Med Chem. 2011 Aug 15;19(16):4882–6. doi: 10.1016/j.bmc.2011.06.069.
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