专利号:US-8598166-B2 优先权日:2008-03-21 标 题:Polysubstituted derivatives of 6-heteroarylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof 发明人:DE PERETTI DANIELLE; EVANNO YANNICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE 权利人:DE PERETTI DANIELLE; EVANNO YANNICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; SANOFI SA 摘要:Compounds of formula (I): n nwherein R 1 , R 2 , R 3 , R 4 , Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
专利号:US-2007031333-A1 优先权日:2003-01-02 标 题:Novel F-18 labeled annexin V, synthesis thereof, and use thereof 发明人:MEASE RONNIE C; TORETSKY JEFFREY A; WEINBERG IRVING N 权利人:MEASE RONNIE C; TORETSKY JEFFREY A; WEINBERG IRVING N 摘要:A method for noninvasive measurement of apoptosis is described. The method includes the steps of labeling Annexin V with a positron emitter, injecting the labeled Annexin V into a target cell group, obtaining an image of the target cell group using a positron emission tomography scanner, and evaluating the image to determine an amount of cell death within the target cell group. The target cell group may be a lesion or a suspected tumor. The positron emitter may be F-18. The step of labeling Annexin V with F-18 may include the steps of selecting an F-18 labeled small molecule containing a protein conjugating group, synthesizing and purifying the selected molecule, producing a high specific activity prosthetic group as a result of the synthesizing and purifying step, and conjugating the prosthetic group to the Annexin V. The produced prosthetic group may be N-succinimidyl-4-[ 18 F]fluorobenzoate (SFB).
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