CAS: 6542-44-5; (4S,4As,5As,6S,12As)-2-Acetyl-4-(Dimethylamino)-3,6,10,12,12A-Pentahydroxy-6-Methyl-4A,5A,6,12A-Tetrahydrotetracene-1,11(4H,5H)-Dione
该化合物是一个复杂的有机化合物,其特点是复杂的多环结构,包括多羟基组和二甲基氨基功能组,其潜在生物活动值得注意,通常在药用化学和药理学方面研究该化合物,乙酰和氢氧组的存在表明,它可能表现出各种化学反应,包括氢结合和与生物巨分子的潜在相互作用,其立体化学学,如多个手工业中心的特定配置所示,可能影响其生物活动和相互作用,与许多有机化合物一样,其溶性,稳定性和再活性可能因溶剂和环境条件而有很大差异,通常需要进一步研究,以阐明其在研究或工业中的全部特性和潜在应用.
- 英文名称(4S,4As,5As,6S,12As)-2-Acetyl-4-(Dimethylamino)-3,6,10,12,12A-Pentahydroxy-6-Methyl-4A,5A,6,12A-Tetrahydrotetracene-1,11(4H,5H)-Dione
- 中文名称土霉素杂质C
- IUPAC名称(4S,4aS,5aS,6S,12aS)-2-acetyl-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,11(4H,5H)-dione
- 其它别名2-Acetyl-2-Decarboxamidooxytetracycline; (4S)-2-Acetyl-3,5β,6α,10,12,12Aβ-Hexahydroxy-4β-(Dimethylamino)-6-Methyl-1,4,4Aβ,5,5Aβ,6,11,12A-Octahydronaphthacene-1,11-Dione; (4S)-2-Acetyl-4β-(Dimethylamino)-4,4Aβ,5,5Aβ,6,12A-Hexahydro-3,5β,6α,10,12,12Aβ-Hexahydroxy-6-Methylnaphthacene-1,11-Dione; 5β-Hydroxy-2-Acetyl-2-Descarbamoyltetracycline; (4S)-2-Acetyl-4-(Dimethylamino)-3,6α,10,12,12Aβ-Pentahydroxy-6-Methyl-4Aβ,5Aβ,6,12A-Tetrahydro-1,11(4H,5H)-Naphthacenedione; (4S)-4β-(Dimethylamino)-1,4,4Aβ,5,5Aβ,6,11,12A-Octahydro-2-Acetyl-3,6α,10,12,12Aβ-Pentahydroxy-6-Methylnaphthacene-1,11-Dione; 2-Descarbamoyl-2-Acetyltetracycline; 1,11(4H,5H)-Naphthacenedione, 2-Acetyl-4-(Dimethylamino)-4A,5A,6,12A-Tetrahydro-3,6,10,12,12A-Pentahydroxy-6-Methyl-, (4S-(4Alpha,4Aalpha,5Aalpha,6Beta,12Aalpha))-
- CAS编号6542-44-5
- MFCD编号:MFCD01713221
- FDA UNII编号:KF6I0R5HOO
- 分子式:C23H25NO8分子量:443.45
- 产品CID: 1636466
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
- 相似结构搜索
- 产品信息参考
;; - InChIKey: VCGJFFLJLRZIHG-OIVQWWNTSA-N
- ZPHAATWBCGBELI-OIVQWWNTSA-N
- 计算化学: 氢键受体数9.0氢键供体数5.0可旋转键数2.0
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902500000-苯乙烯
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专利信息
专利号:US-8486921-B2
优先权日:2006-04-07
标 题:Synthesis of tetracyclines and analogues thereof
发明人：MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU
权利人:MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU; HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetra-cycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-pro liferative agents in the treatment of diseases of humans or other animals.
专利号:US-2010130451-A1
优先权日:2006-04-07
标 题:Synthesis of tetracyclines and analogues thereof
