CAS: 63604-94-4; 2-Bromo-5-Methoxyphenol

该化合物是一种溴化芳香化合物,在苯酚环的5个位置上具有一种甲氧替代物,这种结构具有独特的反应性,使其成为有机合成中有价值的中间体,特别是在制药和农用化学应用中.其溴性能允许通过交叉反应进一步发挥作用,而甲基氧基组则能增强电子密度,影响电子代用替代的再生选择性.该化合物在标准条件下具有中等稳定性,便于实验室的处理.其独特的替代模式有利于建造复杂的分子结构,包括外生循环和生物活性衍生物.在惰性大气下使用,其供应通常具有高纯度,以确保合成工作流程的一贯性.

结构式图片

欧盟法规

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上下游产品

4-Bromoresorcinol dimethyl sulfate O-methylresorcine 1-Bromo-4-methoxy-2-(methoxymethoxy)benzene 1-Bromo-4-methoxy-2-(methoxymethoxy)benzene 2-(allyloxy)-1-bromo-4-methoxybenzene 2-Acetoxy-1-bromo-4-methoxybenzene 1-bromo-2-isopropoxy-4-methoxybenzene

合成工艺路线路线简述

  • 合成目标产物 2-Bromo-5-Methoxyphenol 主要起始原料 Phenol, 2-Bromo-5-Methoxy-, 1-Acetate
  • (文献来源)合成步骤主要原料 Phenol, 2-Bromo-5-Methoxy-, 1-Acetate
2,4-二羟基苯甲酸置于水,溶剂黄146体系中,化学反应生成 2-溴-5-甲氧基苯酚
参考文献:Rice,Journal Of The American Chemical Society,1926,Vol. 48,P. 3127
标题:Rice,Journal Of The American Chemical Society,1926,Vol. 48,P. 3127

海关参考信息

专利信息


专利号:US-6162932-A
优先权日:1995-11-08
标 题 :Stereoselective synthesis of endothelin receptor antagonists
发明人:MILLS ROBERT JOHN; KOWALSKI CONRAD JOHN; PING LI-JENG; GOMBATZ KERRY JOSEPH
权利人:SMITHKLINE BEECHAM CORP
摘要:The present invention is directed to chiral intermediates in a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A). ##STR1##

专利号:WO-9717071-A1
优先权日:1995-11-08
标 题 :Stereoselective synthesis of endothelin receptor antagonists
发明人:MILLS ROBERT JOHN; KOWALSKI CONRAD JOHN; PING LI-JEN; GOMBATZ KERRY JOSEPH
权利人:SMITHKLINE BEECHAM CORP; MILLS ROBERT JOHN; KOWALSKI CONRAD JOHN; PING LI JEN; GOMBATZ KERRY JOSEPH
摘要:The present invention is directed to a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A) and to the chiral intermediates.

专利号:US-6080862-A
优先权日:1995-11-08
标题 :Stereoselective synthesis of endothelin receptor antagonists
发明人:MILLS ROBERT JOHN; KOWALSKI CONRAD JOHN; PING LI-JENG; GOMBATZ KERRY JOSEPH
权利人:SMITHKLINE BEECHAM CORP
摘要:PCT No. PCT/US96/18084 Sec. 371 Date May 8, 1998 Sec. 102(e) Date May 8, 1998 PCT Filed Nov. 8, 1996 PCT Pub. No. WO97/17071 PCT Pub. Date May 15, 1997The present invention is directed to a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A) and to the chiral intermediates

专利号:US-2024335442-A1
优先权日:2021-08-02
标 题:N-acylhydrazone compounds capable of inhibiting nav1.7 and/or nav1.8, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人:BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; GAMBA LUIS EDUARDO REINA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA; LIMA LÃ?DIA MOREIRA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO UFRJ
摘要:N-acylhydrazone compounds that are Nav 1.7 and/or Nav 1.8 inhibitors, including N-acylhydrazone compounds of Formula (I), wherein the substituents R1 to R6 are independently selected from the groups defined in the specification, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits, and which are applicable in the fields of medicinal chemistry and organic synthesis, as well as in the treatment of pain-related disorders.

专利号:JP-2000507918-A
优先权日:1995-11-08
标 题:Stereoselective synthesis of endothelin receptor antagonists

专利号:EP-0915699-A1
优先权日:1995-11-08
标 题 :Stereoselective synthesis of endothelin receptor antagonists
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合成参考文献

参考DOI号:10.1080/00397910601033906
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