CAS: 612-24-8; 2-Nitrobenzonitrile

上下游产品

CAS号3717-25-7 2-nitro-benzald... | CAS号552-89-6 邻硝基苯甲醛 | CAS号1885-29-6 2-氨基苯甲腈 | CAS号612-25-9 2-硝基苯甲醇 | CAS号610-15-1 2-硝基苯甲酰胺 | CAS号100-47-0 苯甲腈 | CAS号10424-94-9 2-Nitrobenzalde... | CAS号609-73-4 邻硝基碘苯 | CAS号447-60-9 邻三氟甲基苯腈 | CAS号384-22-5 2-硝基-Alpha,Alph... | CAS号394-47-8 2-氟苯甲腈 | CAS号34761-09-6 3-氨基苯并[B]噻吩-2-乙酸乙酯 | CAS号4403-69-4 2-氨基苄胺 | CAS号491-36-1 4-Quinazolinone | CAS号1769-24-0 2-甲基-4(1H)-喹唑啉酮 | CAS号38469-85-1 2-甲氧基-6-硝基苯甲腈 | CAS号195-84-6 Tricycloquinazoline | CAS号611-20-1 水杨腈

📜2-氨基苯甲腈置于chromium Silicalite-2 叔丁基过氧化氢体系中,用 甲醇 作为反应溶剂,化学反应 7.0H,以52%的收率获得产物2-硝基苯甲腈
参考文献:铬硅沸石2(crs-2):使用tbhp将伯胺直接氧化为硝基化合物的有效催化剂
标题:铬硅沸石2(crs-2):使用tbhp将伯胺直接氧化为硝基化合物的有效催化剂
摘要:具有mel(crs-2)拓扑结构的含铬中孔分子筛(si:Cr> 140:1)使用70%叔丁基过氧化氢(tbhp)有效催化各种伯胺直接氧化为相应的硝基化合物作为氧化剂.
DOI:10.1039/c39950001523

专利信息

专利号:WO-0027627-A1
优先权日:1998-11-12
标题 :Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles
发明人：WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO
权利人:LILLY CO ELI; WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO
摘要:In its first aspect, the invention is directed to a solid support mediated method for the synthesis of diverse polycyclic heterocycles according to general formula (V). A second aspect of the invention is directed to a solid support bound intermediate compound that optionally can be derivatized before a cyclization and displacement procedure provides a product. The intermediate is preferably stable to a wide range of chemical conditions thus allowing, if desired, for the chemical derivatization of the intermediate. A third aspect of the invention is directed to a library of polycyclic heterocycle compounds where said library contains a plurality of diverse library compounds of general formula (V). A fourth aspect of the invention is directed to a method for the synthesis of a library of diverse polycyclic heterocycles by the general method described. A fifth aspect of the invention is directed to an assay kit for the identification of lead compounds of the library described therein.

专利号:US-9073900-B2
优先权日:2013-10-02
标题:Dihydroquinone derivatives of piperidine and piperazine
发明人：ULLAH NISAR
权利人:UNIV KING FAHD PET & MINERALS; KING ABDULAZIZ CITY SCI & TECH
摘要:The dihydroquinone derivatives of piperidine and piperazine are 7-piperazinyl and 7-piperadinyl-3,4-dihydroquinazolin-2(1H)-ones that exhibit D 2 and 5-HT 1A receptor binding affinities, making them suitable for use as the active ingredient of pharmaceuticals for the treatment of schizophrenia. The derivatives have the general formula: n nwhere X is carbon or nitrogen and R is a group selected from a through f having the formula:n n nor a pharmaceutically acceptable salt thereof. The piperazine compounds are prepared by condensing 4-bromo-2-nitro-benzonitrile with 1-Boc-piperazine (1-tert-butoxycarbonyl-piperazine) to form an intermediate that is converted to a piperazinyl-3,4-dihydroquinazolin-2(1H)-one. Subsequent reductive amination with the biarylaldehydes a through f completes the synthesis of the 7-piperadinyl-3,4-dihydroquinazolin-2(1H)-ones. The piperadinyl compounds are prepared from tert-butyl-4-(2-oxo-1,2,3,4-tetradihydroquinazolin-7-yl)piperidine-1-carboxylate, which is converted to 7-(piperidin-4-yl)-3,4-dihyroquinazolin-2(1H)-one. Subsequent reductive amination with the biarylaldehydes a through f completes the synthesis of the 7-piperidinyl-3,4-dihydroquinazolin-2(1H)-ones.

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:US-4476315-A
优先权日:1982-04-30
标 题:Nucleophilic substitution process
发明人：STAHLY G PATRICK; STAHLY BARBARA C
权利人:ETHYL CORP
摘要:Nitroarylacetic acid esters are prepared by reacting a nitroaromatic compound which is devoid of halogen on the aromatic ring carrying a nitro group with an alpha,alpha-disubstituted acetic acid ester in an inert solvent and in the presence of a base so that the ester undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. Nitrobenzene acetic acids and their esters are useful intermediates for the synthesis of pharmaceuticals.

专利号:US-4818753-A
优先权日:1987-09-18
标题 :Synthesis and method of use for 2, 4 diaminoquinazoline
发明人：COLWELL WILLIAM T; DEGRAW JOSEPH I
权利人:STANFORD RES INST INT
摘要:Compounds of the formula ##STR1## wherein R 1 is H, methyl, ethyl, or chloro and R 2 is hydrocarbyl of 1-12 C are useful as antifungal agents. Compounds of this series wherein R 2 is 7-12 C are novel. A new synthetic method for the compounds is also described.

专利号:DE-102011014082-A1
优先权日:2010-04-26
标题 :Synthesis of tetrazole derivatives