专利号:US-8669356-B2 优先权日:2009-10-21 标 题 :Linker and support for solid phase synthesis of nucleic acid 发明人:HAYAKAWA YOSHIHIRO; TSUKAMOTO MASAKI; MORI KENJIRO; MINOMI KENJIRO; MAETA ERI; KONISHI TATSUYA 权利人:HAYAKAWA YOSHIHIRO; TSUKAMOTO MASAKI; MORI KENJIRO; MINOMI KENJIRO; MAETA ERI; KONISHI TATSUYA; NITTO DENKO CORP; UNIV NAGOYA NAT UNIV CORP 摘要:The invention provides a universal linker capable of synthesizing nucleic acid having a phosphate group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker for solid phase synthesis of nucleic acid contains a compound represented by at least one of the following formulae n nwherein each symbol is as defined in the specification.
专利号:US-7592392-B2 优先权日:2003-04-04 标 题 :Synthesis of functional polymers for use in organic synthesis and combinatorial chemistry 发明人:LINDSLEY CRAIG W; WISNOSKI DAVID D 权利人:MERCK & CO INC 摘要:The present invention relates to a novel process for the preparation of solid-supported scavenging reagents and solid-supported functional polymers. The invention further relates to novel solid-supported functional polymers and to their use in organic synthesis and combinatorial chemistry.
专利号:US-8835656-B2 优先权日:2012-01-30 标 题 :Linker and support for solid phase synthesis of nucleic acid 发明人:TSUKAMOTO MASAKI; SUZUKI NORITAKA; HAYAKAWA YOSHIHIRO; MAETA ERI; MORI KENJIRO; MINOMI KENJIRO 权利人:NITTO DENKO CORP; UNIV NAGOYA NAT UNIV CORP 摘要:The invention provides a universal linker capable of synthesizing nucleic acid having a hydroxy group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker contains a compound represented by the formula n nwherein each symbol is as defined in the specification.
专利号:WO-0078740-A1 优先权日:1999-06-23 标 题 :Solid-supported initiators and functional polymers for use in organic synthesis and combinatorial chemistry 发明人:HARIKRISHNAN LALGUDI SANKARAN; HODGES JOHN COOKE; LINDSLEY CRAIG WILLIAM 权利人:WARNER LAMBERT CO; HARIKRISHNAN LALGUDI SANKARAN; HODGES JOHN COOKE; LINDSLEY CRAIG WILLIAM 摘要:Solid-supported initiator and functional polymers are described as well as methods for the preparation and use in solution phase, solid-phase organic synthesis, and combinational chemistry including use as initiators of solid-supported free-radical polymerization, as solid-supported scavengers for purification of crude solution phase reaction mixtures, as a stationary phase for solid-phase organic synthesis, and as solid-supported reagents in solution-phase organic synthesis.
专利号:US-12065516-B2 优先权日:2021-10-22 标题 :Polymeric solid support for oligonucleotide synthesis 发明人:SONG JINGSHE; CUE JOHN MICHAEL; YAO YUN-CHIAO; YU DAVID; LAU ALDRICH N K 权利人:HONGENE BIOTECH CORP 摘要:Embodiments of the present application relate to porous polymeric beads solid support for use in oligonucleotide synthesis and the method of producing and using the same. Further embodiments relate to porous polymeric beads and method for preparing and using the same.
专利号:US-2006189764-A1 优先权日:2003-04-04 标 题:Synthesis of functional polymers for use in organic synthesis and combinatorial chemistry