CAS: 56341-39-0; 6-Fluoroindolin-2-One

上下游产品

6-氟靛红 6-Fluoroisatin 324-03-8

N-(氯乙酰)-3-氟苯胺置于aluminum (Iii) Chloride体系中,化学反应 72.0H,以65.61%的收率获得产物6-氟吲哚酮
参考文献: Olefin Substituted Oxindoles Having Ampk Activity[fr] Oxindoles Substitués Par Oléfine Ayant Une Activité Sur Ampk
标题: Olefin Substituted Oxindoles Having Ampk Activity[fr] Oxindoles Substitués Par Oléfine Ayant Une Activité Sur Ampk
摘要:本发明涉及具有有价值的药理特性的式(I)化合物,特别是ampk激活剂,因此在治疗某些可以通过激活该受体预防或治疗的疾病方面具有用处.这些化合物适用于治疗和预防可以受该受体影响的疾病,如代谢性疾病,特别是2型糖尿病.

专利信息

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-6514981-B1
优先权日:1998-04-02
标题:Methods of modulating tyrosine protein kinase function with indolinone compounds
发明人：TANG PENG CHO; SUN LI
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

专利号:US-2011046395-A1
优先权日:2008-01-25
标 题 :Process for the manufacture of a 6-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene derivative
发明人：RALL WERNER; PFRENGLE WALDEMAR; SCHNAUBELT JUERGEN
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to a process for the manufacture of the compound 4-[(Z)-[[4-[(dimethylamino)methyl]phenyl]amino](6-fluoro-1,2-dihydro-2-oxo-3H-in-dol-3-ylidene)methyl]-benzenepropanoic acid and to a new intermediate for the synthesis.

专利号:WO-0056709-A1
优先权日:1999-03-24
标 题:Indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
权利人:SUGEN INC; TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-6465507-B2
优先权日:2000-02-28
标题 :3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; MILLER TODD A; LI XIAOYUAN; ZHANG RUOFEI; CUI JINRONG; HUANG PING; WEI CHUNG CHUN
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-6689806-B1
优先权日:1999-03-24
标 题 :Indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS JR G DAVIS; LI XIAOYUAN; LIANG CONGXIN
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.