CAS: 4897-68-1; 1-Bromo-2-Iodo-4-Methoxybenzene

该化合物是一种有机化合物,其特点是芳香结构,包括一个苯环,代之以溴原子,碘原子和甲氧组(OCH3).这些替代成分的存在影响其化学反应和物理特性.溴和碘原子是卤素,可参与各种替代反应,而甲基氧组是一个电子施药组,能够增强芳香环的核糖分.这种化合物一般是无色的,可粉黄的液,具有独特的芳香味.有机溶剂中可溶性,但因其水分恐惧性质,水溶性有限.多种卤素的存在也会影响其稳定性和再活性,使其在合成有机化学中有助于生成更复杂的分子.在处理这种化合物时,应采取安全防范措施,因为溴和碘都是危险物质.

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上下游产品

3-methoxy-1-iodobenzene 2-bromo-5-methoxyaniline 4-iodoanisol 4-bromo-3-nitroanizole 6-methoxybenzonorbornadiene 2-benzylsulfanyl-1-bromo-4-methoxy-benzene 4-bromo-3-[(4-methoxyphenyl)ethynyl]anisole 2-bromo-3',4'-methylenedioxy-5-methoxybiphenyl

合成工艺路线路线简述

    📜2-溴-5-甲氧基苯胺置于盐酸,Potassium Iodide,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应 1.5H,以82%的收率获得产物4-溴-3-碘苯甲醚
    参考文献:非对映选择性氧化ç n / C o和c n / C 可见光引发的n键形成环烷:熔融n-Arylindolines的合成
    标题:非对映选择性氧化ç n / C o和c n / C 可见光引发的n键形成环烷:熔融n-Arylindolines的合成
    摘要:已经开发出了利用可见光光氧化还原催化合成稠合n-芳基二氮杂环林的方法.我们以前曾描述过,光生胺自由基阳离子通过中间的苄基碳正离子反应生成取代的吲哚.在本文中,我们通过用束缚的异亲核试剂捕获苄基碳正离子来扩展该化学方法的应用.探索了光生苄基碳正离子的反应性,并将其应用于具有各种电子特性和环约束的一系列底物.所描述的方法以中等至非常好的收率提供了带有四取代碳立体中心且具有大于99:1非对映选择性的c-2和c-3熔融二氢吲哚.
    DOI:10.1002/adsc.201500317

    海关参考信息

    专利信息


    专利号:US-9790199-B1
    优先权日:2016-12-01
    标题 :Sulfoxide compound and method of producing benzothiophene derivatives using the same
    发明人：WU MING-JUNG; WEN SHIH-MING
    权利人:NAT SUN YAT-SEN UNIV
    摘要:A sulfoxide compound and method of producing benzothiophene derivatives using the same are provided. The sulfoxide compound is represented by formula (I), wherein R 1 and R 2 are individually and independently benzoyl group; alkyl, acyl or silyl group of C 1 -C 6 straight chain or branched chain; or alkenyl group of C 3 -C 6 straight chain or branched chain; and X is halogen atom. The sulfoxide compound reacts with alkynyl compound, and then the synthesis efficiency of benzothiophene derivatives can be effectively increased.

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    主要参考文献

    参考标题:Ring Strain And Total Syntheses Of Modified Macrocycles Of The Isoplagiochin Type
    作者:Andreas Speicher,Timo Backes,Kerstin Hesidens,Jürgen Kolz
    摘要:Macrocycles Of The Bisbibenzyl-Type Are Natural Products That Are Found Exclusively In Bryophytes (Liverworts). The Molecular Framework Of The Subtype "Isoplagiochin" Is Of Substantial Structural Interest Because Of The Chirality Of The Entire Molecule, Which Arises From Two Biaryl Axes In Combination With Two Helical Two-Carbon Units In A Cyclic Arrangement. From A Structural As Well As A Synthetic Point Of View We Report On The Total Synthesis Of Compounds Which Possess More Rigid Two-Carbon Biaryl Bridges Like Stilbene (E Or Z) Or Even Tolane Moieties Which Were Introduced Starting With A Sonogashira Protocol. The Mcmurry Method Proved To Be A Powerful Tool For The Cyclization To These Considerably Ring-Strained Macrocycles.

    合成参考文献


    摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 121.
    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 72.
    摘要:Yoshikai, N.; Rayner, C. M.; Graham, M. A., Science of Synthesis Knowledge Updates, (2020) 2, 99.
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