专利号:US-9555008-B2 优先权日:2008-04-02 标题 :Synthesis of hyperbranched amphiphilic polyester and theranostic nanoparticles thereof 发明人:PEREZ J MANUEL; SANTRA SANTIMUKUL 权利人:UNIV CENTRAL FLORIDA RES FOUND INC 摘要:A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst. The vacuum is then released with a dry inert gas after drying. The dried mixture is heated under the inert gas at a temperature sufficient for polymerization. The inert gas is evacuated while continuing to heat the mixture. The formed polymer is then dissolved in dimethylformamide and precipitated out by adding methanol. Modifications of the method yield nanoparticles of polyesters having properties suited for coencapsulating fluorescent dyes together with therapeutic drugs, resulting in theranostic nanoparticles, that is, nanoparticles useful in both therapeutic treatments and diagnostic methods.
专利号:US-2004181078-A1 优先权日:1997-10-10 标 题 :Tetraphosphonate bicyclic trisanhydrides 发明人:PANKIEWICZ KRZYSZTOF W; LESIAK KRYSTYNA; WATANABE KYOICHI A 权利人:PHARMASSET LTD 摘要:Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.
专利号:WO-2017184870-A1 优先权日:2016-04-21 标题 :Diastereoselective synthesis of (±)-epianastrephin, (±)-anastrephin and analogs thereof
专利号:WO-2024074814-A9 优先权日:2022-10-04 标题 :Composition comprising a functionalised dye and a diallylamine comonomer and use thereof 发明人:CANNON PAUL; DONLEY ADAM; LAWRENCE ANTHONY; WRIGHT GAVIN; TURNER CARL; ROBERTS PHILIP 权利人:SUBLINO LTD; COLOUR SYNTHESIS SOLUTIONS LTD 摘要:The present teachings relate to a composition comprising a functionalised dye and a diallylamine comonomer, and the use of such compositions in methods of colouring a substrate. The present teachings provide improved bonding of a dye to a substrate, and preferably allow colouring to be conducted entirely in the presence of an aqueous solvent.
专利号:US-5663449-A 优先权日:1989-05-19 标 题 :Intermediate compounds in the synthesis of heteroarylpiperidines, pyrrolidines and piperazines
专利号:US-2016256402-A1 优先权日:2008-04-02 标题:Synthesis of hyperbranched amphiphilic polyester and theranostic nanoparticles thereof
摘要:Li, L.; Biscoe, M. R., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 797. 摘要:Wang, C.; Yang, F., Science of Synthesis: Special Topics, (2022) 1, 459.