CAS: 471-80-7; (4R,4As,6Ar,9S,11Ar,11Bs)-9-Hydroxy-4,11B-Dimethyl-8-Methylenetetradecahydro-6A,9-Methanocyclohepta[a]Naphthalene-4-Carboxylic Acid

该化合物是来自Stevia植物的天然化合物,特别是来自Stevia rebaudiana的叶叶子的天然化合物,是一种二叶,以糖性能著称,作为Steviol glysides的甘蔗的甘蔗,其特点是双循环结构,具有有助于其生物活动的结合环系统. (-)-Steviol通常是白到苍白的黄色晶状固体,其水溶性相对较低,但有机溶剂可溶性较易溶.它有甜味,比sucrose要甜得多,在食品和饮料应用中成为流行的替代甜食.此外,(-)-Steviol对药理学感兴趣,因为它具有潜在的健康利益,包括其在葡萄代谢新陈代谢及其低卡路里含量. 其安全性特征已得到评估,导致批准在不同国家使用该物质,并且具有功能性能性食品工业整体(Sevi-eximal-ex-eximeal),(S-ex-ex-ex-viol).

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CAS号64977-89-5 steviol 19β-glu... | CAS号64849-39-4 甜茶苷

合成工艺路线路线简述

    📜13-[(2-O-6-Deoxy-β-D-Glucopyranosyl-β-D-Glucopyranosyl)Oxy]-Ent-Kaur-16-En-19-Oic Acid β-D-Glucopyranosyl Ester置于pectinase From Aspergillus Niger,水体系中,化学反应 48.0H,反应生成 甜叶菊甙元
    参考文献:甜叶菊中新型二萜糖苷的结构
    标题:甜叶菊中新型二萜糖苷的结构
    摘要:从甜叶菊的商业提取物中,除了已知的甜菊糖苷,包括甜菊糖苷,莱鲍迪苷af,茜草苷和杜尔可甙a,还分离了两种新的二萜类苷.两种新化合物的结构鉴定为13-[(2-O-6-脱氧-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基)氧基] Ent-Kaur-16-En-19-油酸β-D-吡喃葡萄糖基酯(1)和13-[(2-O-6-脱氧-β-D-吡喃葡萄糖基-3-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基)氧基] Ent-Kaur-16-En-19-Oic Acidβ-D-吡喃葡萄糖基酯(2),基于广泛的NMR和ms光谱数据以及化学研究.
    DOI:10.1016/j.Carres.2011.03.025

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    专利信息


    专利号:US-2023091651-A1
    优先权日:2021-09-20
    标 题:Dietary supplement and method for synthesis of same
    发明人:WYNN JASON R
    权利人:StrongCell LLC
    摘要:A dietary supplement and method for synthesis of the same are disclosed. In one embodiment of the method, an NADH component is provided that includes at least partially microencapsulated nicotinamide having nicotinamide blended with water. A supplement component, such as collagen, coenzyme Q10, vitamins, and minerals, is provided. A mixed component, which is a liquid, is formed by mixing the NADH component with the supplement component at ambient conditions. The mixed component is subjected to a fill production process.

    专利号:US-2023089537-A1
    优先权日:2021-09-20
    标题:Dietary supplement and method for synthesis of same
    发明人:WYNN JASON R
    权利人:StrongCell LLC
    摘要:A dietary supplement and method for synthesis of the same are disclosed. In one embodiment of the method, an NADH component is provided which includes NADH from about 0.1% to about 0.5% blended with water from about 40% to about 84% both by weight of the dietary supplement. A supplement component from about 9% to about 99% by weight of the dietary supplement is also provided. The supplement component may include collagen in about 2% to about 10%, vitamins in about 0.00001% to about 3%, and minerals in about 0.000002% to about 0.5% all by weight of the dietary supplement. A mixed component is formed by mixing the NADH component with the supplement component at ambient conditions. The mixed component is a liquid at ambient conditions having a pH of less than 4.0. The mixed component is subjected to a cold fill production process.

    专利号:WO-2024042405-A1
    优先权日:2022-08-26
    标 题:Compositions and methods for the synthesis of bio-based polymers
    发明人:OLIVEIRA ANA; CAPÊTO ANA PAULA; PINTADO MANUELA
    权利人:AMYRIS BIO PRODUCTS PORTUGAL UNIPESSOAL LTDA; UNIV CATOLICA PORTUGUESA
    摘要:The present disclosure provides compositions and methods for the synthesis of bio-based polymers (e.g., polyurethanes and polyesters) from secondary materials produced during a fermentation process. The disclosure also features intermediates produced during these processes, as well as compositions containing the same.

    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-10533205-B1
    优先权日:2013-10-09
    标 题:Kaurenoic acid glycoside precursors and methods of synthesis
    发明人:ZIPP BRANDON
    权利人:VITALITY BIOPHARMA INC
    摘要:Ent-kaurenoic acid glycoside precursor compositions and synthesis methods are provided. The KA-19-monoside, KA-19-bioside and KA-19-trioside precursors can be used as starting materials for a variety of kaurenoic acid based reactions. The precursors provide alternative synthesis pathways for steviol glycosides to the natural pathway based on Steviol biosynthesis. The alternative synthesis pathways using the precursors also circumvent the rate limiting step of the natural Steviol biosynthesis pathway. The precursors can be used individually or in combination to produce a mixture or individual steviol glycosides such as Rebaudioside A, Rebaudioside D or Rebaudioside M. Control over the precursor quantities and composition allows control over the composition of the resulting steviol glycosides that are finally produced.

    专利号:US-2023407357-A1
    优先权日:2022-05-20
    标 题 :Biomanufacturing of oligosaccharides and derivatives from simple sugar
    发明人:HOEPKER ALEXANDER CHRIS; CORGIE STEPHANE CEDRIC; SAVINO KEITH
    权利人:ZYMTRONIX CATALYTIC SYSTEMS INC
    摘要:The invention provides methods for glycosylation and preparation of compounds. The compounds include galactosylated, sialylated, fucosylated, and N-acetylglucosaminylated compounds from simple animal-derived, plant-derived, or microbe-derived oligosaccharides and sugars. In certain embodiments, the invention provides trinucleotide-free enzymatic production of oligosaccharides starting from simple sugars that include plant-based sugars. The invention also provides the enzymatic production of fucosylated oligosaccharides and fucosylated antibody-glycan conjugates from common sugars. The production may be a cell-free, one-pot synthesis using enzymes, and in some embodiments, immobilized enzymes. The synthesis is a highly customizable and highly efficient cell-free manufacturing process. In some embodiments, lactose derivatives and human milk oligosaccharides (HMOs) are produced.

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    主要参考文献


    1: Ruddat M, Heftmann E, Lang A. Biosynthesis of steviol. Arch Biochem Biophys. 1965 Jun;110(3):496-9. doi: 10.1016/0003-9861(65)90441-8. 111(1):187-90. doi: 10.1016/0003-9861(65)90338-3. 211(5052):971-2. doi: 10.1038/211971a0. 74(2):188-93. German. doi: 10.1007/BF00388328. (2):173-8. doi: 10.1039/p19760000173. 36(5):519-20. doi: 10.1007/BF01965774. 24(11):1269-71. doi: 10.1021/jm00143a001. 19(1):47-53. doi: 10.1016/0304-3835(83)90134-9. 21(1):29-35. doi: 10.1016/0304-3835(83)90079-4. 47(3):439-44. doi: 10.1021/np50033a007. 41(1):55-7. doi: 10.1007/BF02005871. 34(6):873-82. doi: 10.1016/0006-2952(85)90769-5. 82(8):2478-82. doi: 10.1073/pnas.82.8.2478.
    14: Pezzuto JM, Nanayakkara NP, Compadre CM, Swanson SM, Kinghorn AD, Guenthner TM, Sparnins VL, Lam LK. Characterization of bacterial mutagenicity mediated by 13-hydroxy-ent-kaurenoic acid (steviol) and several structurally-related derivatives and evaluation of potential to induce glutathione S-transferase in mice. Mutat Res. 1986 Mar;169(3):93-103. doi: 10.1016/0165-1218(86)90088-1. 82(4):909-15. doi: 10.1104/pp.82.4.909.
    16: Ishii EL, Bracht A. Glucose release by the liver under conditions of reduced activity of glucose 6-phosphatase. Braz J Med Biol Res. 1987;20(6):837-43. 50(3):434-41. doi: 10.1021/np50051a015. 15(4):211-22. doi: 10.1002/bms.1200150405. Erratum in: Biomed Environ Mass Spectrom 1988 Jun 1;15(11):635. (107):83-7. Japanese. 95(1):152-6. doi: 10.1104/pp.95.1.152.

    合成参考文献


    参考文献:10.1021/np040062t.s001
    摘要:New Diterpenoids from the Marine Mangrove Bruguiera gymnorrhiza. (). doi: 10.1021/np040062t.s001.
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