CAS: 404874-93-7; (R)-1-(4-Fluorophenyl)-5-(2-Oxo-4-Phenyloxazolidin-3-yl)Pentane-1,5-Dione

英文名称(R)-1-(4-Fluorophenyl)-5-(2-Oxo-4-Phenyloxazolidin-3-yl)Pentane-1,5-Dione
中文名称依折麦布杂质8对映体
IUPAC名称(R)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
其它别名(R)-1-(4-Fluorophenyl)-5-(2-Oxo-4-Phenyloxazolidin-3-yl)Pentane-1,5-Dione; 1,5-Pentanedione, 1-(4-Fluorophenyl)-5-[(4R)-2-Oxo-4-Phenyl-3-Oxazolidinyl]-; Ezetimibe Impurity 8 Enantiomer; 3-[5-(1,5-Dioxo-5-(P-Fluophenylpentyl]-4R-Phenyl-2-Oxazolidinone; Ezetimibe Impurity Enantiomer; (R)-1-(4-Fluorophenyl)-5-(2-Oxo-4-Phenyloxazolidin-3-yl)Pentane-1,5-Dione? (Ezetimibe Impurity）; 1,2-Di(Furan-2-yl)Ethanone
CAS编号404874-93-7
MFCD编号:MFCD28400023
FDA UNII编号:NFC2JCZ9VE
分子式:C20H18FNO4分子量:355.36
产品CID: 1418180

相似结构搜索
InChIKey: XXSSRSVXDNUAQX-KRWDZBQOSA-N
InChI=1S/C20H18FNO4/c21-16-11-9-15(10-12-16)18(23)7-4-8-19(24)22-17(13-26-20(22)25)14-5-2-1-3-6-14/h1-3,5-6,9-12,17H,4,7-8,13H2/t17-/m0/s1
计算化学: 氢键受体数5.0氢键供体数*可旋转键数6.0

MSDS等安全信息

警示词warning
危险描述H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
防范说明P264+P280+P305+P351+P338+P337+P313
安全声明H303+H313+H333

上下游产品

(S)-4-phenyl-2-oxazolidinone pivaloyl chloride 5-(4-fluorophenyl)-5-oxopentanoic acid (R)-1-(4-fluorophenyl)-5-oxo-5-[(S)-2-oxo-4-phenyloxazolidin-3-yl]pentyl acetate 3-{(2R,3S)-3-[(4-fluorophenyl)amino]-2-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]-3-[4-(benzyloxy)phenyI]propanoyl}-(4S)-4-phenyl-1,3-oxazolidin-2-one 4(S)-(4-benzyloxyphenyl)-1-(4-fluorophenyl)-3(R)-{2-[2-(4-fluorophenyI)-5,5-dimethyl-[1,3]-dioxan-2-yl]-ethyl}azetidine-2-one

合成工艺路线路线简述

📜(R)-4-苯基-2-唑烷酮,4-(4-氟苯甲酰基)丁酸置于三甲基乙酰氯,三乙胺,Lithium Chloride体系中,化学反应生成依折麦布杂质8对映体
参考文献:用于合成抗高胆固醇血症药物依折麦布的高效且可扩展的方法
标题:用于合成抗高胆固醇血症药物依折麦布的高效且可扩展的方法
摘要:摘要描述了一种通过手性埃文斯助剂 (S)-4-苯基-2-恶唑烷酮合成抗高胆固醇药物依折麦布的有效且可扩展的方法.该过程的关键步骤是 (S)-3-(5-(4-氟苯基)-5,5-二甲氧基戊酰基)-4-苯基恶唑烷-2-One 和 N-(4-((叔丁基二甲基甲硅烷基))氧基)亚苄基)-4-氟苯胺,以及依折麦布-酮与nabh4/i2的立体选择性还原,这首先应用于依折麦布的合成.该工艺简洁,温和,操作方便,立体选择性高(依折麦布de值的99.6%).此外,还合成了依泽替米贝的三种非对映异构体,作为产品质量控制的参考.图形概要
DOI:10.1080/00397911.2016.1221969