CAS: 3598-37-6; 1-(10-(3-(Dimethylamino)Propyl)-10H-Phenothiazin-2-yl)Ethan-1-One Maleate

该化合物是一种主要用作兽医药物中安定剂和镇静剂的苯并胺衍生物,其特征是能够抑制多巴胺受体,从而产生镇静效应;该物质看起来像一种黄色至橙色晶状粉末,在水中溶解,适合各种配方,包括注射溶液;在手术或其他压力程序之前,甲状腺炎经常用于...

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    专利号:US-9751868-B2
    优先权日:2012-02-28
    标题 :Benzocyanine compounds
    发明人：HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA R; LEHMANN FRANK G; NLEND MARIE CHRISTINE
    权利人:HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA R; LEHMANN FRANK G; NLEND MARIE CHRISTINE; PIERCE BIOTECHNOLOGY INC; DYOMICS GMBH
    摘要:Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

    专利号:US-9249307-B2
    优先权日:2011-08-16
    标题:Benzocyanine compounds
    发明人：HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA; LEHMANN FRANK G; NLEND MARIE CHRISTINE
    权利人:HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA; LEHMANN FRANK G; NLEND MARIE CHRISTINE; PIERCE BIOTECHNOLOGY INC
    摘要:Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

    专利号:US-9486471-B2
    优先权日:2012-03-28
    标题:Combination therapy for the treatment of cancer
    发明人：BHATIA MICKIE; SACHLOS ELEFTHERIOS
    权利人:UNIV MCMASTER
    摘要:Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods and compositions are useful for the treatment of cancers such as acute myeloid leukemia.

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    主要参考文献


    1: Koh RB, Isaza N, Xie H, Cooke K, Robertson SA. Effects of maropitant, acepromazine, and electroacupuncture on vomiting associated with administration of morphine in dogs. J Am Vet Med Assoc. 2014 Apr 1;244(7):820-9. doi: 10.2460/javma.244.7.820. doi: 10.1016/j.tvjl.2012.03.017. Epub 2012 Apr 23. doi: 10.2460/ajvr.73.5.595. doi: 10.2460/ajvr.75.3.231. doi: 10.7589/2014-02-052. Epub 2014 Jul 11. doi: 10.2460/ajvr.72.11.1427. doi: 10.2460/javma.246.7.754. doi: 10.1016/j.rvsc.2011.10.004. Epub 2011 Nov 1. doi: 10.1016/j.jemermed.2012.11.088. Epub 2013 Mar 20. doi: 10.1007/s13181-014-0416-1.
    13: Simon BT, Scallan EM, Siracusa C, Henderson A, Sleeper MM, Larenza Menzies MP. Effects of acepromazine or methadone on midazolam-induced behavioral reactions in dogs. Can Vet J. 2014 Sep;55(9):875-85.
    14: López-Sanromán FJ, Gómez Cisneros D, Varela del Arco M, Santiago Llorente I, Santos González M. The use of low doses of acepromazine as an aid for lameness diagnosis in horses: An accelerometric evaluation. Vet Comp Orthop Traumatol. 2015;28(5):312-7. doi: 10.3415/VCOT-14-11-0177. Epub 2015 Jul 29. doi: 10.1016/j.rvsc.2013.03.022. Epub 2013 May 2. doi: 10.1111/jsap.12105. doi: 10.1111/ceo.12157. Epub 2013 Jul 15. doi: 10.1016/j.tvjl.2014.01.018. Epub 2014 Feb 5. doi: 10.1111/j.1467-2995.2012.00736.x. Epub 2012 Jun 26. doi: 10.2460/javma.237.10.1155. Erratum in: J Am Vet Med Assoc. 2011 jAN 15;238(2):182. Dosage error in published abstract; MEDLINE/

    合成参考文献


    摘要:Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals, 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989, 11(6), 1989
    摘要:Journal of Analytical Toxicology., 22(166), 1998 []
    摘要:Acta Pharmacologica et Toxicologica., 19(87), 1962 []
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