CAS: 21901-40-6; 4-Methyl-5-Nitropyridin-2-Amine

上下游产品

CAS号695-34-1 2-氨基-4-甲基吡啶 | CAS号5832-44-0 4-甲基-3-硝基吡啶 | CAS号33245-30-6 N-(4-甲基吡啶-2-基)硝酰胺 | CAS号7664-93-9 硫酸 | CAS号475060-21-0 N-(5-氟-4-甲基吡啶-2... | CAS号393-53-3 3-氟吡啶-4-羧酸 | CAS号3430-27-1 3-氨基-4-甲基吡啶 | CAS号907545-47-5 2-氯-5-硝基吡啶-4-甲酸... | CAS号399-88-2 3-氟-4-甲基吡啶 | CAS号179555-05-6 2-Pyridinamine,... | CAS号301222-66-2 4-甲基-2-氨基-5-氟吡啶 | CAS号21901-41-7 2-羟基-4-甲基-5-硝基吡啶 | CAS号800401-67-6 5-氯-1H-吡咯并[2,3-... | CAS号6635-90-1 2-甲氧基-5-硝基-4-甲基吡啶

3-硝基-4-甲基吡啶置于4-氨基-1,2,4-三氮唑,Potassium Tert-Butylate体系中,用 二甲基亚砜 用作溶剂,化学反应 5.0H,以61%的收率获得2-氨基-4-甲基-5-硝基吡啶
参考文献:Selective Vicarious Nucleophilic Amination Of 3-Nitropyridines
标题:Selective Vicarious Nucleophilic Amination Of 3-Nitropyridines
摘要:通过代亲核取代反应,九种 3-硝基吡啶化合物和 4-硝基异喹啉在 6 位(4-硝基异喹啉在 1 位)被胺化.使用了两种胺化试剂:羟胺和 4-氨基-1,2,4-三唑.产率从中等到非常好不等.使用羟胺可以直接获得几乎纯净的产品,而 4-氨基-1,2,4-三唑则可以为某些底物提供更好的胺化产品收率.由此,我们获得了一种制备 3-或 4-取代的 2-氨基-5-硝基吡啶的通用方法.
Doi:10.1039/b008660F

专利信息

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-11384076-B2
优先权日:2017-08-18
标 题:Synthesis, pharmacology and use of new and selective FMS-like tyrosine kinase 3 (FLT3) FLT3 inhibitors
发明人：MAHBOOBI SIAVOSH; SELLMER ANDREAS; PONGRATZ HERWIG; PILSL BERNARDETTE; KRÄMER OLIVER; KINDLER THOMAS; BEYER MANDY
权利人:UNIV REGENSBURG; UNIV DER JOHANNES GUTENBERG UNIV MAINZ
摘要:The present invention relates to small molecule compounds of formula (I) and their use as FLT3 inhibitors for the treatment of various diseases, such as acute myeloid leukemia (AML). The present invention further relates to methods of synthesizing the compounds and methods of treatment.