📜苯胺置于三乙胺体系中,用 二氯甲烷,乙腈 用作溶剂,化学反应 20.0H,反应生成毒草胺 参考文献:Thioimidazoline Based Compounds Reverse Glucocorticoid Resistance In Human Acute Lymphoblastic Leukemia Xenografts 标题:Thioimidazoline Based Compounds Reverse Glucocorticoid Resistance In Human Acute Lymphoblastic Leukemia Xenografts 摘要:糖皮质激素是小儿急性淋巴细胞白血病化疗方案的重要组成部分,对糖皮质激素治疗的初次反应不佳预示着较差的预后. Doi:10.1039/c5Ob00779H
专利号:WO-2024256370-A1 优先权日:2023-06-13 标 题 :Synthesis of glufosinate using an amidase-based process 发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.
专利号:US-2025120400-A1 优先权日:2021-12-10 标题:Synthesis of glufosinate using a hydantoinase-based process 发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.
专利号:US-11919928-B2 优先权日:2016-03-16 标题 :Method for producing dihydrotentoxin 发明人:KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI 权利人:KUMIAI CHEMICAL INDUSTRY CO 摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.
专利号:US-2021386068-A1 优先权日:2018-11-07 标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides 发明人:KISTER JEREMY; SATCHIVI NORBERT M 权利人:CORTEVA AGRISCIENCE LLC 摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.
专利号:US-2021352899-A1 优先权日:2018-11-07 标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides 发明人:KISTER JEREMY; SATCHIVI NORBERT M 权利人:CORTEVA AGRISCIENCE LLC 摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.
专利号:ES-2717283-T3 优先权日:2012-07-24 标 题:Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and herbicides inhibitors of VLCFA synthesis and synthesis of fatty acids / lipids
1: Quanrud GM, Lyu Z, Balamurugan SV, Canizal C, Wu HT, Genereux JC. Cellular Exposure to Chloroacetanilide Herbicides Induces Distinct Protein Destabilization Profiles. ACS Chem Biol. 2023 Jul 21;18(7):1661-1676. doi: 10.1021/acschembio.3c00338. Epub 2023 Jul 10. 2: Tresnakova N, Impellitteri F, Famulari S, Porretti M, Filice M, Caferro A, Savoca S, D Iglio C, Imbrogno S, Albergamo A, Vazzana I, Stara A, Di Bella G, Velisek J, Faggio C. Fitness assessment of Mytilus galloprovincialis Lamarck, 1819 after exposure to herbicide metabolite propachlor ESA. Environ Pollut. 2023 Aug 15;331(Pt 1):121878. doi: 10.1016/j.envpol.2023.121878. Epub 2023 May 25. 58(5):379-388. doi: 10.1080/03601234.2023.2208995. Epub 2023 May 7. 8(5):4694-4702. doi: 10.1021/acsomega.2c06561. 5: Yang Y, Ghatge S, Ko Y, Yoon Y, Ahn JH, Kim JJ, Hur HG. Non-specific degradation of chloroacetanilide herbicides by glucose oxidase supported Bio- Fenton reaction. Chemosphere. 2022 Apr;292:133417. doi: 10.1016/j.chemosphere.2021.133417. Epub 2021 Dec 23. 44(22):4151-4166. doi: 10.1002/jssc.202100551. Epub 2021 Sep 22. 22(13):6876. doi: 10.3390/ijms22136876.
合成参考文献
摘要:World Review of Pest Control., 9(119), 1970 摘要:Eksperimentalna Meditsina i Morfologiya., 13(123), 1974 摘要:Environmental Health Criteria 147: Propachlor pp. 13-18 (1993) by the International Programme on Chemical Safety (IPCS) under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization. 摘要:U.S. Environmental Protection Agency/Office of Prevention, Pesticides, and Toxic Substances. Reigart, J.R., Roberts, J.R. Recognition and Management of Pesticide Poisonings. 5th ed. 1999. EPA Document No. EPA 735-R-98-003, and available in electronic format at: 摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present