CAS: 1498-47-1; Allylphosphonic Dichloride

上下游产品

O,O-bis(trimethylsilyl) allyl phosphonic acid diester allyldiphenylphosphine oxide (2S,4R,5R)-2-Allyl-3-isopropyl-4-methyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide bis(4-methoxyphenyl) allylphosphonate diphenyl allylphosphonate

📜溴代环丙烷置于三氯化铝,三氯化磷,水体系中,用85%的收率获得二氯化烯丙基膦
参考文献:环丙基膦酸二乙酯及其硫,硒类似物的合成研究
标题:环丙基膦酸二乙酯及其硫,硒类似物的合成研究
摘要:摘要 描述了合成未取代的环丙基膦酸二乙酯的两种方法.一种方法是环丙基溴化镁与氯亚磷酸二乙酯反应生成环丙基亚膦酸二乙酯,然后用高碘酸钠氧化成相应的膦酸酯.或者,二乙基环丙基亚膦酸酯与元素硫或硒反应,分别得到硫代和硒代类似物.第二种方法涉及从 3-溴丙基膦酸二乙酯中独家 1,3-消除 Hbr.该方法可用于 1,2-或 1,3-消除反应,根据所使用的溶剂产生丙烯基膦酸酯或环丙基膦酸酯.
Doi:10.1080/00397910701845332

专利信息

专利号:US-5219845-A
优先权日:1991-04-25
标题:Phosphonates as anti-inflammation agents
发明人：SALARI HASSAN; BITTMAN ROBERT
权利人:UNIV BRITISH COLUMBIA
摘要:The invention pertains to the synthesis and use as therapeutic agents of a group of substances with a glycerol backbone or aliphatic chain structure linked to a phosphorus atom and a polar head group. Depending on the polar head group, the substance has anti-cancer, anti-inflammatory, anti-allergy or anti-cardiovascular disease properties. Compounds of the formula: wherein n is 0 to 14 and R1 is an alkyl group of C12-C20, R2 is a methyl group, and wherein R3 is an inositol analog head group, a (CH2)mN+(CH3)3 group with m=2 to 10, a serine head group, or an ethanolamine head group, or of the formula wherein R1 and R2 are as described above, n=0 or 1, and R3 is (CH2)mN+(CH3)3 (m=2-10) are claimed. This invention also pertains to the synthesis and use as therapeutic agents of a group of substances that have no glycerol backbone but have an aliphatic chain structure linked directly to a phosphorus atom of the general formula R-P(O)(O-)OR' wherein R is a long-chain alkyl group such as hexadecyl or octadecyl and R' is a head group such as choline, glycerol, inositol, ethanolamine, or serine.

专利号:US-5369097-A
优先权日:1991-04-25
标题 :Phosphonates as anti-cancer agents
发明人：SALARI HASSAN; BITTMAN ROBERT
权利人:UNIV BRITISH COLUMBIA
摘要:This invention pertains to the synthesis and use as therapeutic agents of a group of substances with a glycerol backbone or aliphatic chain structure linked to a phosphorus atom and a polar head group. Depending on the polar head group, the substance has anti-cancer, anti-inflammatory, anti-allergy or anti-cardiovascular disease properties. Compounds of the formula: wherein n is 0 to 14 and R1 is an alkyl group of C12-C20, R2 is a methyl group, and wherein R3 is an inositol analog head group, a (CH2)mN+(CH3)3 group with m=2 to 10, a serine head group, or an ethanolamine head group, or of the formula wherein R1 and R2 are as described above, n=0 or 1, and R3 is (CH2)mN+(CH3)3(m=2-10 ) are claimed. This invention also pertains to the synthesis and use as therapeutic agents of a group of substances that have no glycerol backbone but have an aliphatic chain structure linked directly to a phosphorus atom of the general formula R-P(O)(O-)OR' wherein R is a long-chain alkyl group such as hexadecyl or octadecyl and R' is a head group such as choline, glycerol, inositol, ethanolamine, or serine.

专利号:KR-101965572-B1
优先权日:2018-09-20
标 题:Synthesis method of flame retarding diol, flame retarding diol for the production of thermoplastic polyurethane, and thermoplastic polyurethane having the same

专利号:CN-109232313-B
优先权日:2018-11-07
标 题 :Synthesis method of malononitrile