CAS: 13924-95-3; Methyl 5-Hydroxypyrazine-2-Carboxylate

相似化合物

77168-84-4 859064-08-7 77168-77-5

上下游产品

methanol 5-hydroxypyrazinoic acid 4,5-dihydro-5-oxo-2-pyrazinecarboxylic acid 4,5-dihydro-5-oxo-2-pyrazinecarboxamide methyl 5-chloropyrazine-2-carboxylate 5-bromopyrazine-2-carboxylic acid methyl ester 5-(piperidin-1-yl)pyrazine-2-carboxylic acid {2-[6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1H-indazol-3-yl]-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl}-(5-piperidin-1-yl-pyrazin-2-yl)methanone sodium salt

3-Carbamoyl-1,6-Dihydro-6-Oxo-2-Pyrazinecarboxylic Acid置于sodium Hydroxide,氯化亚砜,硝基苯体系中,用 水 用作溶剂,化学反应 8.0H,反应生成5-羟基吡嗪-2-羧酸甲酯
参考文献:抗球虫药.七.4,5-二氢-5-氧代-2-吡嗪羧酸一氧化物的合成.
标题:抗球虫药.七.4,5-二氢-5-氧代-2-吡嗪羧酸一氧化物的合成.
摘要:1,6-二氢-6-氧代-2,3-吡嗪二甲腈(4)的水解产物为钠氢1,6-二氢-6-氧代-2,3-吡嗪二羧酸盐(6),通过一系列反应包括脱羧和酯化,将其转化为甲基1,6-二氢-6-氧代-2-吡嗪羧酸酯(10)和甲基4,5-二氢-5-氧代-2-吡嗪羧酸酯(12).尽管从12合成4,5-二氢-5-氧代-2-吡嗪羧酸1-氧化物(2)未成功,但其6-甲基衍生物3是从4的5-甲基类似物合成的.
Doi:10.1248/cpb.28.3057

专利信息

专利号:US-2016130259-A1
优先权日:2013-06-24
标题 :Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
发明人：LIU HONG; DAI XING; PALANI ANANDAN; HE SHUWEN; NARGUND RAVI; XIAO DONG; DANG QUN; PENG XUANJIA; LI PENG
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9744173-B2
优先权日:2014-04-10
标题 :2-amino 6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
发明人：BRODNEY MICHAEL AARON; BECK ELIZABETH MARY; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; BARREIRO GABRIELA; LACHAPELLE ERIK ALPHIE; ROGERS BRUCE NELSEN
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variable R 1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-9751895-B2
优先权日:2015-09-24
标 题:N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)-1,3-thiazol-4-yl]amides
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; VERHOEST PATRICK ROBERT; MIKOCHIK PETER JUSTIN; MURRAY JOHN CHARLES; HOU XINJUN
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variables R 1 , R 2 and R 3 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.