CAS: 1310746-10-1; 3-(2,6-Dichloro-3,5-Dimethoxyphenyl)-1-(6-((4-(4-Ethylpiperazin-1-yl)Phenyl)Amino)Pyrimidin-4-yl)-1-Methylurea Phosphate
该化合物是一种针对纤维增生因子受体(FGFRs)的小型分子抑制剂,具体来说是FGFR1-3,旨在有选择地阻塞FGFR信号路径,这些路径在某些癌症(如胆碱酯酶瘤和肠皮癌)中往往受到调控,磷酸盐形式增加了溶性,增加了生物利用率,便利了口服管理.Infigratinib 磷酸盐通过抑制扩散和在FGFR驱动的恶性肿瘤中诱发流行病,表现出强大的抗脉冲活动.其临床相关性在于它能够克服与FGFR抑制剂一起观察到的抗药机制.该化合物正在调查其在精密的临床治疗潜力,特别是对FGFFR变形病人而言.
- 英文名称3-(2,6-Dichloro-3,5-Dimethoxyphenyl)-1-(6-((4-(4-Ethylpiperazin-1-yl)Phenyl)Amino)Pyrimidin-4-yl)-1-Methylurea Phosphate
- 中文名称NVP BGJ398 磷酸盐
- IUPAC名称3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea phosphate
- 其它别名N'-(2,6-Dichloro-3,5-Dimethoxyphenyl)-N-(6-(4-(4-Ethylpiperazin-1-yl)Anilino)Pyrimidin-4-yl)-N-Methylurea Phosphate (1:1); 3-(2,6-Dichloro-3,5-Dimethoxyphenyl)-1-[6-[4-(4-Ethylpiperazin-1-yl)Anilino]Pyrimidin-4-Yl]-1-Methylurea; Phosphoric Acid; Nvp-Bgj3
- CAS编号1310746-10-1
- MFCD编号:MFCD26960938
- FDA UNII编号:58BH47BV6S
- 分子式:C26H34Cl2N7O7P分子量:658.48
- 产品CID: 471622
- 同类组份化合物CAS872511-34-7 (free base)1310746-10-1 (phosphate)1310746-11-2 (monohydrate)1310746-12-3 (mesylate)
- 产品分类生物化工 → 生化试剂 → 激动剂抑制剂
物理性质
MSDS等安全信息
合成工艺路线路线简述
📜Fgfr抑制剂(Nvp-Bgj398)置于磷酸体系中,用 水,异丙醇 用作溶剂,化学反应 0.5H,以70%的收率获得nvpbgj398磷酸盐
参考文献: Crystalline Forms Of 3-(2,6-Dichloro-3,5-Dimethoxy-Phenyl)-1-{6-[4-(4-Ethyl-Piperazin-1-yl)-Phenylamino]-Pyrimidin-4-Yl}-1-Methyl-Urea And Salts Thereof.[fr] Formes Cristallines De La 3-(2,6-Dichloro-3,5-Diméthoxy-Phényl)-1-{6-[4-(4-éthyl-Pipérazin-1-yl)-Phénylamino]-Pyrimidin-4-Yl}-1-Méthyl-Urée Et De Ses Sels
标题: Crystalline Forms Of 3-(2,6-Dichloro-3,5-Dimethoxy-Phenyl)-1-{6-[4-(4-Ethyl-Piperazin-1-yl)-Phenylamino]-Pyrimidin-4-Yl}-1-Methyl-Urea And Salts Thereof.[fr] Formes Cristallines De La 3-(2,6-Dichloro-3,5-Diméthoxy-Phényl)-1-{6-[4-(4-éthyl-Pipérazin-1-yl)-Phénylamino]-Pyrimidin-4-Yl}-1-Méthyl-Urée Et De Ses Sels
摘要:目前的技术提供了3-(2,6-二氯-3,5-二甲氧基苯基)-1-{6-[4-(4-乙基哌嗪-1-基)-苯基氨基]-嘧啶-4-基}-1-甲基脲的新型无水和水合晶型形式,以及其单磷酸盐的非晶和无水结晶多型体,以及盐酸盐,包括其二水合物.该技术还提供了制备各种形式的方法,含有它们的组合物,以及使用它们的治疗方法.
海关参考信息
- 2903919090-氯苯
2905110000-甲醇
2907221000-对苯二酚
2908191000-对氯苯酚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2025137620-A1
优先权日:2023-12-21
标题:Methods for high quality and high accuracy methylation sequencing
发明人：KENNEDY ANDREW
权利人:GUARDANT HEALTH INC
摘要:Provided herein are methods and compositions for calibrating one or more base calling metrics in a sequencing by synthesis reaction, and for calling at least a portion of nucleobases in a converted region of a DNA molecule using the one or more calibrated base calling metrics. Provided herein are also methods for determining the likelihood that a subject has a disease or condition, such as cancer.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Sahores A, May M, Sequeira G, Fuentes C, Jacobsen B, Lanari C, Lamb CA. Targeting FGFR with BGJ398 in breast cancer: Effect on tumor growth and metastasis. Curr Cancer Drug Targets. 2017 Dec 13. doi: 10.2174/1568009618666171214114706. [Epub ahead of print] doi: 10.1016/S1470-2045(17)30902-6. Epub 2017 Dec 7. doi: 10.3892/or.2017.6127. Epub 2017 Dec 1. doi: 10.1200/JCO.2017.75.5009. Epub 2017 Nov 28. doi: 10.1158/1535-7163.MCT-15-1010. Epub 2017 Mar 2.
7: Nogova L, Sequist LV, Perez Garcia JM, Andre F, Delord JP, Hidalgo M, Schellens JH, Cassier PA, Camidge DR, Schuler M, Vaishampayan U, Burris H, Tian GG, Campone M, Wainberg ZA, Lim WT, LoRusso P, Shapiro GI, Parker K, Chen X, Choudhury S, Ringeisen F, Graus-Porta D, Porter D, Isaacs R, Buettner R, Wolf J. Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study. J Clin Oncol. 2017 Jan 10;35(2):157-165. Epub 2016 Nov 21. doi: 10.1172/JCI83926. Epub 2016 Apr 11.
9: Schmidt K, Moser C, Hellerbrand C, Zieker D, Wagner C, Redekopf J, Schlitt HJ, Geissler EK, Lang SA. Targeting Fibroblast Growth Factor Receptor (FGFR) with BGJ398 in a Gastric Cancer Model. Anticancer Res. 2015 Dec;35(12):6655-65. doi: 10.1093/hmg/ddv441. Epub 2015 Oct 22. doi: 10.1158/1078-0432.CCR-14-3357. Epub 2015 May 26.
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