CAS: 130433-68-0; 2,6-Dichloro-1-Fluoropyridin-1-Ium Trifluoromethanesulfonate

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107263-95-6 140623-89-8 52193-54-1

上下游产品

CAS号2402-78-0 2,6-二氯吡啶 | CAS号1493-13-6 三氟甲烷磺酸 | CAS号17228-74-9 2,6-二氯-4-羟基吡啶 | CAS号135183-03-8 N-Fluoro-6-chlo...

📜2,6-二氯吡啶,三氟甲磺酸置于fluorine体系中,用 Various Solvent(S) 用作溶剂,化学反应 3.0H,以62%的收率获得1-氟-2,6-二氯吡啶三氟甲磺酸盐
参考文献:N-氟吡啶鎓盐的合成及性质
标题:N-氟吡啶鎓盐的合成及性质
摘要:各种稳定的 N-氟吡啶鎓盐,带有非亲核性或弱亲核性抗衡阴离子,例如 Tfo−,Fso3−,Bf4−,Sbf6−,Clo4−,Ch3So3− 等,或带有给电子或吸电子取代基合成了吡啶环上的化合物并研究了它们的性质.还合成了 N-氟吡啶鎓-2-磺酸盐,N-氟喹啉鎓三氟甲磺酸盐和高度受阻的 N-氟-2,6-二-叔丁基吡啶鎓盐.它们是通过不稳定的吡啶-F2 化合物的抗衡阴离子置换反应,吡啶盐与质子酸或甲硅烷基酯与 F2 的氟化和/或吡啶的路易斯酸络合物的氟化来合成的.详细检查了每种方法的范围.每种 N-氟吡啶鎓盐都被指定为第一个稳定的 1:1 基于光谱和元素分析的吡啶核和卤素原子的盐结构.稳定性取决于抗衡阴离子的亲核性或碱性以及环的电子性质或位置...
Doi:10.1246/bcsj.64.1081

专利信息

专利号:US-8558012-B2
优先权日:2009-03-02
标 题:2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative, production method thereof, and production method of monofluoromethyl group-containing compound using the same
发明人：SHIBATA NORIO
权利人:SHIBATA NORIO; NAGOYA INST TECHNOLOGY; TOSOH P TECH INC
摘要:A 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethyl group introduction agent that is effective as an intermediate in pharmaceutical and agrochemical synthesis, a production method thereof, and a production method of a monofluoromethyl group-containing compound using this 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative are provided. The 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative represented by the following general formula (1) (wherein R 1 , R 2 , R 3 , and R 4 each independently represent a hydrogen atom, a straight-chain or branched alkyl group having 1 to 4 carbon atoms, a straight-chain or branched alkyloxy group having 1 to 4 carbon atoms, a halogen atom, a nitro group, or a cyano group), the production method thereof, and various monofluoromethyl group-containing compounds are manufactured using this 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethylating agent.

专利号:US-8648090-B2
优先权日:2007-11-08
标 题:Indole alkaloid derivatives having opioid receptor agonistic effect, and therapeutic compositions and methods relating to same
发明人：TAKAYAMA HIROMITSU; KITAJIMA MARIKO; MATSUMOTO KENJIRO; HORIE SYUNJI
权利人:TAKAYAMA HIROMITSU; KITAJIMA MARIKO; MATSUMOTO KENJIRO; HORIE SYUNJI; UNIV CHIBA NAT UNIV CORP; JOSAI UNIVERSITY CORP
摘要:Indole alkaloid derivatives having an opioid receptor agonistic effect, their synthesis, and therapeutic compositions containing these derivatives, and methods of treating conditions with these compounds and therapeutic compositions, are provided.