专利号:US-11745159-B2 优先权日:2017-10-20 标题:Heated nanowells for polynucleotide synthesis 发明人:MARSH EUGENE P; INDERMUHLE PIERRE F; PECK BILL JAMES 权利人:TWIST BIOSCIENCE CORP 摘要:Defined sequence RNA synthesis by 3′→5′ direction is now well established and currently in use for synthesis and development of vast variety of therapeutic grade RNA and Si RNA etc. A number of such synthetic RNA requires a modification or labeling of 3′-end of an oligonucleotide. The synthesis of 3′-end modified RNA requiring lipophilic, long chain ligands or chromophores, using 3′→5′ synthesis methodology is challenging, requires corresponding solid support and generally results in low coupling efficiency and lower purity of the final oligonucleotide in general because of large amount of truncated sequences containing desired hydrophobic modification. We have approached this problem by developing reverse RNA monomer phosphoramidites for RNA synthesis in 5′→3′-direction. They lead to very clean oligonucleotide synthesis allowing for introduction of various modifications at the 3′-end.
专利号:US-2006128939-A1 优先权日:2004-12-03 标题 :One pot process for making polymeric antioxidants 发明人:KUMAR VIJAYENDRA; YANG SUIZHOU; CHOLLI ASHOK L 权利人:KUMAR VIJAYENDRA; YANG SUIZHOU; CHOLLI ASHOK L 摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes mono-deacetylating, polymerizing and deacetylating an aryl monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
专利号:WO-2019079769-A1 优先权日:2017-10-20 标 题:HEATED NANOWELLS FOR THE SYNTHESIS OF POLYNUCLEOTIDES
专利号:US-3455961-A 优先权日:1966-02-23 标 题:Synthesis of 2,3-dihydro-2,2,4-trimethyl-7-benzofuranol 发明人:WEBER HARRY W JR 权利人:FMC CORP
专利号:CN-114436831-A 优先权日:2020-11-02 标 题:Synthesis method of chiral 1-phenylpropyl acetate compound
专利号:CN-1238779-A 优先权日:1996-11-22 标题:Methods and compounds for inhibiting the release of beta-amyloid peptide and/or its synthesis