CAS: 935666-88-9; (S)-5-Chloro-N2-(1-(5-Fluoropyrimidin-2-yl)Ethyl)-N4-(5-Methyl-1H-Pyrazol-3-yl)Pyrimidine-2,4-Diamine
该化合物是一个小分子抑制器,主要以其在针对Janus kinase(JAK)路径,特别是JAK2中发挥作用而闻名.该化合物在药理学领域因其潜在的治疗应用,特别是在治疗各种发炎和自发性疾病以及某些类型的癌症方面,引起了注意.AZD-1480, 显示了动脉抑制器的典型特征,包括调节细胞扩散和生存信号路径的能力.其行动机制涉及有选择地抑制JAK2, 它对若干细胞和生长因素的信号具有关键作用.在临床学前研究中,AZD-1480展示了减少炎和肿瘤生长的效果,使其成为进一步临床调查的候选条件.然而,像许多调查药物一样,其安全性特征,药效和长期影响是正在进行的研究的主题.
- 英文名称(S)-5-Chloro-N2-(1-(5-Fluoropyrimidin-2-yl)Ethyl)-N4-(5-Methyl-1H-Pyrazol-3-yl)Pyrimidine-2,4-Diamine
- 中文名称5-氯-N2-[(1S)-1-(5-氟-2-嘧啶基)乙基]-N4-(5-甲基-1H-吡唑-3-基)-2,4-嘧啶二胺
- IUPAC名称(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
- 其它别名5-Chloro-N2-[(1S)-1-(5-Fluoro-2-Pyrimidinyl)Ethyl]-N4-(5-Methyl-1H-Pyrazol-3-yl)-2,4-Pyrimidinediamine; 5-Chloro-N2-[(1S)-1-(5-Fluoropyrimidin-2-yl)Ethyl]-N4-(5-Methyl-1H-Pyrazol-3-yl)Pyrimidine-2,4-Diamine
- CAS编号935666-88-9
- MFCD编号:MFCD16038904
- EINECS号:641-076-0
- FDA UNII编号:KL2Z2TLF01
- 分子式:C14H14ClFN8分子量:348.77
- 产品CID: 1975212
- 产品分类生物化工 → 抑制剂 → 酪氨酸蛋白激酶/信号转导子和转录活化子抑制剂(JAK/STAT)
物理性质
- 熔点>205°C (分解)
- 沸点575.2±60.0 °C at 760 mmHg
- 闪点301.7±32.9 °C
- 密度1.5±0.1 g/cm3
- pKa:13.73±0.10(预测)
- PSA:107.53
- LogP:1.6
- 折射率1.702
- 蒸汽压0.0±1.6 mmHg at 25°C
- 溶解性Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
- 外观形态白色至米色粉末
- 储存条件-20°C
- 产品应用该化合物用于上胃肠胃肠癌肾上腺瘤外细胞模型的体外细胞模式,并与肉瘤组结合,研究与肿瘤有关的大型细胞代为存活的眼膜细胞.
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine (1S)-1-(5-fluoropyrimidin-2-yl)ethanamine monohydr°Chloride 5- fluoropyrimidine-2-carbonitrile (S)-tert-butyl-1-(5-fluoropyrimidin-2-yl)ethylcarbamate合成工艺路线路线简述
- 935666-88-9 + 110-16-7 = 935666-88-9
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Ethanol,Water; Rt -> 60 °C
标题:Use Of ω-Transaminase Enzyme Chemistry In The Synthesis Of A Jak2 Kinase Inhibitor
作者:Frodsham,Lianne; Golden,Michael; Hard,Susan; Kenworthy,Martin N.; Klauber,David J.; Et Al
参考文献:Organic Process Research & Development 日期:2013 卷标:17(9) 页码:1123-1130
📜(S)-Tert-Butyl-1-(5-Fluoropyrimidin-2-yl)Ethylcarbamate置于盐酸,Potassium Hydrogencarbonate,Potassium Hydroxide体系中,用 2-甲基-2-丁醇,乙醇,水,异丙醇 作为反应溶剂,化学反应 74.0H,反应生成 5-氯-N2-[(1S)-1-(5-氟-2-嘧啶基)乙基]-N4-(5-甲基-1H-吡唑-3-基)-2,4-嘧啶二胺
参考文献:Use Of ω-Transaminase Enzyme Chemistry In The Synthesis Of A Jak2 Kinase Inhibitor
标题:Use Of ω-Transaminase Enzyme Chemistry In The Synthesis Of A Jak2 Kinase Inhibitor
摘要:Omega-Transaminase Enzyme Chemistry Provides An Excellent Methodology To Build Synthetically Useful Chiral Amines From Their Corresponding Ketones. An Application Of This Methodology,Providing A Long-Term Commercial Manufacturing Route To A Jak2 Kinase Inhibitor,Is Reported Herein.
DOI:10.1021/op400133D
海关参考信息
- 2921199090-其他无环单胺
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.
专利号:CN-118922420-A
优先权日:2022-03-25
标题 :Synthesis of TYK2 inhibitors and their intermediates
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Liu Y, Holdbrooks AT, De Sarno P, Rowse AL, Yanagisawa LL, McFarland BC, Harrington LE, Raman C, Sabbaj S, Benveniste EN, Qin H. Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis. J Immunol. 2014 Jan 1;192(1):59-72. doi: 10.4049/jimmunol.1301513. Epub 2013 Dec 9.
2: Sun ZL, Tang YJ, Wu WG, Xing J, He YF, Xin DM, Yu YL, Yang Y, Han P. AZD1480 can inhibit the biological behavior of ovarian cancer SKOV3 cells in vitro. Asian Pac J Cancer Prev. 2013;14(8):4823-7. doi: 10.1158/1078-0432.CCR-13-0422. Epub 2013 Aug 13. doi: 10.1634/theoncologist.2013-0198. Epub 2013 Jul 11.
5: Chang Q, Bournazou E, Sansone P, Berishaj M, Gao SP, Daly L, Wels J, Theilen T, Granitto S, Zhang X, Cotari J, Alpaugh ML, de Stanchina E, Manova K, Li M, Bonafe M, Ceccarelli C, Taffurelli M, Santini D, Altan-Bonnet G, Kaplan R, Norton L, Nishimoto N, Huszar D, Lyden D, Bromberg J. The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia. 2013 Jul;15(7):848-62.
合成参考文献
摘要:S55 | ZINC15PHARMA | Pharmaceuticals from ZINC15 | DOI:10.5281/zenodo.3247749
📝 需求与反馈
尽可能描述清楚需求与问题信息
