CAS: 89787-12-2; (2-Isopropylphenyl)Boronic Acid

该化合物是有机有机体化合物,其特征是,一个附于一个苯环上的碱性酸功能组,该元素组又被异丙基组替代,该化合物一般是白色的白色和白色的固体,在极地有机溶剂中可溶解,表现出与二醇形成可逆共价联系的能力,使其在各种应用中有用,特别是在有机合成和药用化学中.

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1-bromo-2-isopropylbenzene Triisopropyl borate 1-bromo-2-phenylpropane 2-bromo-2'-isopropylbiphenyl 4-(2-isopropylphenyl)-6-methoxy-1,2-dihydronaphthalene 4-iso-butyl-6-(2-iso-propylphenyl)pyridazine-3-carboxylic acid dicyclohexyl(2′-isopropylbiphenyl-2-yl)phosphine

合成工艺路线路线简述

  • 7073-94-1 = 89787-12-2
    反应条件:1.1 Reagents: Tert-Butyllithium Solvents: Pentane,Tetrahydrofuran; 2 H,-78 °C1.2 Reagents: Triisopropyl Borate Solvents: Tetrahydrofuran; -78 °C; -78 °C -> Rt; Overnight,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Rt1.4 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 30 Min,Rt1.5 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt
    标题:9,10-Diarylanthracenes As Molecular Switches: Syntheses,Properties,Isomerizations And Their Reactions With Singlet Oxygen
    作者:Zehm,Daniel; Fudickar,Werner; Hans,Melanie; Schilde,Uwe; Kelling,Alexandra; Et Al
    参考文献:Chemistry - A European Journal 日期:2008 卷标:14(36) 页码:11429-11441]

    7073-94-1 = 89787-12-2
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 15 Min,-78 °C1.2 Reagents: Triisopropyl Borate Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C; 1 H,-78 °C -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Water
    标题:Group 4 Dimethylsilylenebisamido Complexes Bearing The 6-[2-(Diethylboryl)Phenyl]Pyrid-2-Yl Motif: Synthesis And Use In Tandem Ring-Opening Metathesis/vinyl-Insertion Copolymerization Of Cyclic Olefins With Ethylene
    作者:Zou,Yuanlin; Wang,Dongren; Wurst,Klaus; Kuehnel,Christa; Reinhardt,Ingrid; Et Al
    参考文献:Chemistry - A European Journal 日期:2011 卷标:17(49) 页码:13832-13846]

    = 89787-12-2
    反应条件:1.1 Solvents: Acetonitrile-D3,Water-D2; 24 H,Rt
    标题:Fast And Tight Boronate Formation For Click Bioorthogonal Conjugation
    作者:Akgun,Burcin; Hall,Dennis G.
    参考文献:Angewandte Chemie 日期:2016 卷标:55(12) 页码:3909-3913]

    7073-94-1 = 89787-12-2
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 15 Min,-78 °C1.2 Reagents: Triisopropyl Borate Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C; 1 H,-78 °C -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Group 4 Metal Complexes Bearing The Aminoborane Motif: Origin Of Tandem Ring-Opening Metathesis/vinyl-Insertion Polymerization
    作者:Wang,M.; Xu,G.; Wang,D.; Zou,Y.; Frey,W.; Et Al
    参考文献:Polymer Chemistry 日期:2015 卷标:6(17) 页码:3290-3304]

    7073-94-1 = 89787-12-2
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 2 H,-78 °C1.2 Reagents: Triisopropyl Borate Solvents: Tetrahydrofuran; 1 H,-78 °C; 1 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Structure,Conformation,And Dynamic Processes Of The Stereolabile Atropisomers Of Hindered Terphenyl Hydrocarbons
    作者:Lunazzi,Lodovico; Mazzanti,Andrea; Minzoni,Mirko; Anderson,J. Edgar
    参考文献:Organic Letters 日期:2005 卷标:7(7) 页码:1291-1294]

    2842844-65-7 = 89787-12-2 + 98-80-6
    反应条件:1.1 Reagents: Carbamide Peroxide Solvents: Dmso-D6,Water,Water-D2; Rt
    标题:Hydrogen Peroxide-Responsive Triggers Based On Borinic Acids: Molecular Insights Into The Control Of Oxidative Rearrangement
    作者:Gatin-Fraudet,Blaise; Pucher,Mathilde; Le Saux,Thomas; Doisneau,Gilles; Bourdreux,Yann; Et Al
    参考文献:Chemistry - A European Journal 日期:2022 卷标:28(59)
1-溴-2-异丙基苯置于正丁基锂,硼酸三异丙酯,盐酸体系中,用 四氢呋喃,正己烷,水 作为反应溶剂,化学反应 2.25H,以60.2%的收率获得产物2-异丙基苯硼酸
参考文献:带有6 [[2-(二乙基硼基)苯基]吡啶-2-基的4组二甲基甲硅烷基双酰胺基配合物:环烯烃与乙烯的串联开环复分解/乙烯基插入共聚反应的合成和应用
标题:带有6 [[2-(二乙基硼基)苯基]吡啶-2-基的4组二甲基甲硅烷基双酰胺基配合物:环烯烃与乙烯的串联开环复分解/乙烯基插入共聚反应的合成和应用
摘要:带有6 [[2-(二乙基硼基)苯基]吡啶-2-基基序的两个基于zr Iv和hf Iv的双酰胺基配合物,即[zrcl 2 {me 2 Si(dbppn)2 }(thf)] (9)和[hfcl 2 {me 2 Si(dbppn)2 }(thf)2](10)(dbppn = 6-[2-(二乙基硼基)苯基]吡啶-2-酰胺基)的制备.已经将它们的反应性与不带有氨基硼烷基序的模型预催化剂进行了比较.用甲基铝氧烷活化后,预催化剂9和10在乙烯(e)的均聚中具有活性,可生产高密度聚乙烯(hdpe).在e与环戊烯(cpe)的共聚中,例如通过9的作用,Cpe的存在导致e的聚合活性急剧增加,而cpe的掺入保持接近或为零.在9的作用下,降冰片2烯(nbe)与e的乙烯基插入共聚反应中,获得了这两种单体的统计环烯烃共聚物.然而,在较高的nbe浓度下,9导致nbe与e的可逆开环复分解(romp)/乙烯基插入聚合(v
DOI:10.1002/chem.201101829

海关参考信息

专利信息


专利号:US-10799495-B2
优先权日:2017-01-13
标 题:Aaptamine alkaloid derivatives and synthesis method and application thereof
发明人:LIN HOUWEN; YANG FAN
权利人:RENJI HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
摘要:A benzodiazepine alkaloid compound and a pharmaceutically acceptable salt thereof, the structure of the compound being shown in general formula (I). n n n n n n n n n n in the formula (I), R 1 , R 2 and R 3 independently are hydrogen, C 1-4 alkyl or C 1-4 alkanoyl; one from among R 4 and R 5 is a benzene ring or a substituted benzene ring, while the other is hydrogen, a benzene ring or a substituted benzene ring, wherein a substituent group on the substituted benzene ring is hydroxyl, cyano, amino, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylamine, C 1-4 alkanoyl or C 1-4 alkoxyacyl. A method for synthesizing the compound and a use in the preparation of anti-tumor drugs. The compound shown in formula (I) may be used for preparing anti-tumor, especially anti-lung cancer, drugs as well as anti-fungal drugs.

专利号:US-7833926-B2
优先权日:2005-07-01
标题 :Arylphenoxy catalyst system for producing ethylene homopolymer or copolymers of ethylene and α-olefins
发明人:WOO TAE WOO; OK MYUNG AHN; HAHN JONG SOK; LEE MAL-OU; KANG SANG OOK; KO SUNG-BO; KIM TAE-JIN; KIM SUNG-KWAN
权利人:SK ENERGY CO LTD
摘要:The present invention relates to an arylphenoxy catalyst system producing an ethylene homopolymer or copolymers of ethylene and α-olefins, and a method of producing an ethylene homopolymer or copolymers of ethylene and α-olefins having a high molecular weight under a high temperature solution polymerization condition using the same. The catalyst system includes a group IV arylphenoxy-based transition metal catalyst and an aluminoxane cocatalyst or a boron compound cocatalyst. In the transition metal catalyst, a cyclopentadiene derivative and arylphenoxide as fixed ligands are located around the group IV transition metal, arylphenoxide is substituted with at least one aryl derivative and is located at the ortho position thereof, and the ligands are not crosslinked to each other. The catalyst includes an environmentally-friendly raw material, synthesis of the catalyst is economical, and thermal stability of the catalyst is excellent. It is useful for producing an ethylene homopolymer or copolymers of ethylene and α-olefins having various physical properties in commercial polymerization processes.

专利号:US-2009069334-A1
优先权日:2007-08-18
标题:Pyridazine based alpha-helix mimetics
发明人:REBEK JR JULIUS; BIROS SHANNON; MOISAN LIONEL; VOLONTERIO ALESSANDRO; MANN ENRIQUE; DALE TREVOR
权利人:SCRIPPS RESEARCH INST
摘要:The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available building block, 6. These scaffolds may be thought of as synthetic counterparts of amphiphilic α-helices having a “wet faceâ€? along one side and a hydrophobic face along the other side of the helix.

专利号:US-8933018-B2
优先权日:2011-02-07
标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
发明人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA
权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.

专利号:WO-2024179572-A1
优先权日:2023-03-01
标题:Aromatic-ring compound and use thereof
发明人:LI JIN; WANG QINGYANG; WANG XIAOTAO; LI XIAOMEI; DOU DENGFENG; MENG XIAOYUN; LI XIANYANG; CHEN QIUXIA; GUO ANPING; Zheng nuo; HU HONG; HE WEI
权利人:HITGEN INC
摘要:Provided are a new compound having a binding effect on the E3 ligase protein TRIM21, and the use thereof in the preparation of a drug for treating abnormal cell proliferation diseases. Further provided is an intermediate compound in the synthesis process of a proteolysis-targeting bifunctional compound.
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主要参考文献

参考标题:Palladium-Catalyzed Tandem C-C Activation/cyclization Induced By Carbopalladation Of Functionalized Nitriles: Synthesis Of Benzo Dipyrromethenes
作者:Lepeng Chen,Julin Gong,Yetong Zhang,Yinlin Shao,Zhongyan Chen,Renhao Li,Jiuxi Chen |发布日期:2020.9.4
摘要:A Palladium-Catalyzed Carbon-Carbon Bond Activation-Initiated Reaction Of 2-(3-Phenyloxiran-2-Yl)Benzonitriles With Arylboronic Acids Is Reported. Multiple Chemical Bonds Were Cleavaged And Reconstructed Via β-Carbon Elimination In This Reaction, Enabling The Construction Of Valuable Benzo-Fused Dipyrromethenes That Are Difficult To Prepare By Other Methods. Additionally, A Series Of Benzannulated

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摘要:Zhang, J., Science of Synthesis Knowledge Updates, (2010) 4, 256.
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