2842844-65-7 = 89787-12-2 + 98-80-6 反应条件:1.1 Reagents: Carbamide Peroxide Solvents: Dmso-D6,Water,Water-D2; Rt 标题:Hydrogen Peroxide-Responsive Triggers Based On Borinic Acids: Molecular Insights Into The Control Of Oxidative Rearrangement 作者:Gatin-Fraudet,Blaise; Pucher,Mathilde; Le Saux,Thomas; Doisneau,Gilles; Bourdreux,Yann; Et Al 参考文献:Chemistry - A European Journal 日期:2022 卷标:28(59)
专利号:US-10799495-B2 优先权日:2017-01-13 标 题:Aaptamine alkaloid derivatives and synthesis method and application thereof 发明人:LIN HOUWEN; YANG FAN 权利人:RENJI HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE 摘要:A benzodiazepine alkaloid compound and a pharmaceutically acceptable salt thereof, the structure of the compound being shown in general formula (I). n n n n n n n n n n in the formula (I), R 1 , R 2 and R 3 independently are hydrogen, C 1-4 alkyl or C 1-4 alkanoyl; one from among R 4 and R 5 is a benzene ring or a substituted benzene ring, while the other is hydrogen, a benzene ring or a substituted benzene ring, wherein a substituent group on the substituted benzene ring is hydroxyl, cyano, amino, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylamine, C 1-4 alkanoyl or C 1-4 alkoxyacyl. A method for synthesizing the compound and a use in the preparation of anti-tumor drugs. The compound shown in formula (I) may be used for preparing anti-tumor, especially anti-lung cancer, drugs as well as anti-fungal drugs.
专利号:US-7833926-B2 优先权日:2005-07-01 标题 :Arylphenoxy catalyst system for producing ethylene homopolymer or copolymers of ethylene and α-olefins 发明人:WOO TAE WOO; OK MYUNG AHN; HAHN JONG SOK; LEE MAL-OU; KANG SANG OOK; KO SUNG-BO; KIM TAE-JIN; KIM SUNG-KWAN 权利人:SK ENERGY CO LTD 摘要:The present invention relates to an arylphenoxy catalyst system producing an ethylene homopolymer or copolymers of ethylene and α-olefins, and a method of producing an ethylene homopolymer or copolymers of ethylene and α-olefins having a high molecular weight under a high temperature solution polymerization condition using the same. The catalyst system includes a group IV arylphenoxy-based transition metal catalyst and an aluminoxane cocatalyst or a boron compound cocatalyst. In the transition metal catalyst, a cyclopentadiene derivative and arylphenoxide as fixed ligands are located around the group IV transition metal, arylphenoxide is substituted with at least one aryl derivative and is located at the ortho position thereof, and the ligands are not crosslinked to each other. The catalyst includes an environmentally-friendly raw material, synthesis of the catalyst is economical, and thermal stability of the catalyst is excellent. It is useful for producing an ethylene homopolymer or copolymers of ethylene and α-olefins having various physical properties in commercial polymerization processes.
专利号:US-2009069334-A1 优先权日:2007-08-18 标题:Pyridazine based alpha-helix mimetics 发明人:REBEK JR JULIUS; BIROS SHANNON; MOISAN LIONEL; VOLONTERIO ALESSANDRO; MANN ENRIQUE; DALE TREVOR 权利人:SCRIPPS RESEARCH INST 摘要:The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available building block, 6. These scaffolds may be thought of as synthetic counterparts of amphiphilic α-helices having a “wet faceâ€? along one side and a hydrophobic face along the other side of the helix.
专利号:US-8933018-B2 优先权日:2011-02-07 标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof 发明人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA 权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC 摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.
专利号:WO-2024179572-A1 优先权日:2023-03-01 标题:Aromatic-ring compound and use thereof 发明人:LI JIN; WANG QINGYANG; WANG XIAOTAO; LI XIAOMEI; DOU DENGFENG; MENG XIAOYUN; LI XIANYANG; CHEN QIUXIA; GUO ANPING; Zheng nuo; HU HONG; HE WEI 权利人:HITGEN INC 摘要:Provided are a new compound having a binding effect on the E3 ligase protein TRIM21, and the use thereof in the preparation of a drug for treating abnormal cell proliferation diseases. Further provided is an intermediate compound in the synthesis process of a proteolysis-targeting bifunctional compound.
参考标题:Palladium-Catalyzed Tandem C-C Activation/cyclization Induced By Carbopalladation Of Functionalized Nitriles: Synthesis Of Benzo Dipyrromethenes 作者:Lepeng Chen,Julin Gong,Yetong Zhang,Yinlin Shao,Zhongyan Chen,Renhao Li,Jiuxi Chen |发布日期:2020.9.4 摘要:A Palladium-Catalyzed Carbon-Carbon Bond Activation-Initiated Reaction Of 2-(3-Phenyloxiran-2-Yl)Benzonitriles With Arylboronic Acids Is Reported. Multiple Chemical Bonds Were Cleavaged And Reconstructed Via β-Carbon Elimination In This Reaction, Enabling The Construction Of Valuable Benzo-Fused Dipyrromethenes That Are Difficult To Prepare By Other Methods. Additionally, A Series Of Benzannulated
合成参考文献
摘要:Zhang, J., Science of Synthesis Knowledge Updates, (2010) 4, 256.