CAS: 88847-89-6; 2-Amino-9-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-3H-Purine-6,8(7H,9H)-Dione

上下游产品

CAS号96964-90-8 8-苄氧基-2'-脱氧鸟苷 | CAS号961-07-9 2'-脱氧鸟苷 | CAS号13389-03-2 8-溴2‘-脱氧鸟苷 | CAS号107-02-8 丙烯醛

📜2'-脱氧鸟苷置于大鼠1,25-二羟基维生素d(1,25(Oh)2D)试剂盒,Hexacyanoferrate(Iii)体系中,用 水 作为反应溶剂,以16%的收率获得产物8-Oh-脱氧鸟嘌呤
参考文献:Vieira,A. J. S. C.; Candeias,L. P.; Steenken,S.,Journal De Chimie Physique Et De Physico-Chimie Biologique,1993,Vol. 90,# 4,P. 881-898
标题:Vieira,A. J. S. C.; Candeias,L. P.; Steenken,S.,Journal De Chimie Physique Et De Physico-Chimie Biologique,1993,Vol. 90,# 4,P. 881-898

专利信息

专利号:US-2023313255-A1
优先权日:2020-07-15
标题:Massively Parallel Enzymatic Synthesis of Polynucleotides
发明人：HORGAN ADRIAN; LACHAIZE HENRI; VERARDO DOMIANO; GODRON XAVIER
权利人:DNA SCRIPT
摘要:The invention is directed to methods and compositions for inkjet assisted synthesis of a plurality of polynucleotides at reaction sites on a substrate using template-free polymerases, such as, terminal deoxynucleotidyl transferases (TdTs). Compositions of the invention include formulations of synthesis reagents for inkjet delivery including, but not limited to, TdT coupling reaction buffers and 3′-O-protected dNTP monomers.

专利号:US-12421628-B2
优先权日:2018-07-23
标题:Massively parallel enzymatic synthesis of nucleic acid strands
发明人：HORGAN ADRIAN; GODRON XAVIER; YBERT THOMAS; NICOL ROBERT
权利人:DNA SCRIPT
摘要:The invention is directed to methods for massively parallel template-free enzymatic synthesis of a plurality of different polynucleotides of predetermined sequences. In one aspect, methods of the invention employ large scale arrays of reaction sites each associated with at least one working electrode for controlling deprotection and deblocking steps at predetermined user selected sites. In another aspect, the invention provides template-free enzymatic synthesis with proofreading, wherein completed polynucleotides at predetermined reaction sites are sequenced using a sequencing by synthesis technique, particularly employing electrochemically labile blocking groups.

专利号:EP-0901500-B1
优先权日:1996-05-03
标题:In situ preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides
发明人：ZHANG ZHAODA; TANG JIN-YAN
权利人:AVECIA BIOTECHNOLOGY INC
摘要:The invention provides novel bifunctional phosphitylating reagents and their application in in situ preparation of 5'-protected nucleoside phosphoramidites and synthesis of oligonucleotides. Bifunctional phosphitylating reagents according to the invention react quickly with nucleosides under weakly acidic conditions. In addition, the bifunctional phosphitylating reagents according to the invention generate chemoselectively the corresponding nucleoside phosphoramidites in situ, without need to purify the nucleoside phosphoramidites before using them in oligonucleotide synthesis. Finally, the bifunctional phosphitylating reagents according to the invention are relatively stable and easy to handle.

专利号:US-2024052391-A1
优先权日:2020-10-29
标 题 :Enzymatic Synthesis of Polynucleotide Probes
发明人：GODRON XAVIER; NIYOMCHON SUPAPORN; CHAMPION ELISE
权利人:DNA SCRIPT
摘要:The present invention is directed to methods and kits for enzymatic synthesis of labeled polynucleotide probes using template-free DNA polymerases.

专利号:WO-2023170258-A1
优先权日:2022-03-11
标 题 :Apparatus for enzymatic synthesis of a plurality of polynucleotides comprising a condensation trap
发明人：MCCUSKER SEAN; HAO GRACE
权利人:DNA SCRIPT
摘要:An apparatus (500) for enzymatic synthesis of a plurality of polynucleotides, the apparatus (500) comprising a chiller (11) with a condensation generating device (8) and a condensation trap (1) comprising a frame with a front surface (2) and an opposing back surface (4) connected by first and second lateral sides (6), wherein the frame houses a U-shaped inner structure that is formed by two opposing inner side surfaces (12) connected by an inner bottom surface (14), wherein the U-shaped inner structure forms a space traversing the frame between the front surface (2) and the back surface (4), the space configured to accommodate a protuberance of the condensation generating device (8), wherein the inner bottom surface (14) comprises a trough (10) configured to collect condensate from the condensation generating device (8), the trough (10) comprising a sloped surface (16) angled downward from a top edge (18) nearest the back surface (4) to a bottom edge (20) nearest the front surface (2), the bottom edge (20) connecting to a first edge (22) of a condensate channel (23), wherein the condensation trap (1) also comprises a plate (24) forming part of the front surface (2) of the frame and forming a vertical wall of the trough along a second edge of the condensate channel (23) across from the first edge (22), wherein the condensate channel (23) slopes downwards, terminating at an aperture (26), wherein the aperture (26) is in fluid communication with a tubing connector (28).

专利号:US-2022315970-A1
优先权日:2019-09-09
标题:Template-Free Enzymatic Polynucleotide Synthesis Using Photocleavable Linkages
发明人：HORGAN ADRIAN
权利人:DNA SCRIPT
摘要:The present invention is directed to methods and kits for template-free enzymatic synthesis of polynucleotides employing photocleavable linkages. In some embodiments, such methods include using 3′-O—NH2-dNTP monomers which may react with photocleavage products having free ketone to allow synthesis and purification on the same or an added support.