CAS: 875781-17-2; 5-Bromo-1H-Pyrazolo[3,4-B]Pyridine

该化合物是一种杂交循环化合物,在5号位置用一种[3-4-b] 核心替换为溴原子,该结构是医药化学和药物研究,特别是生物活性分子合成的多用途中间体,其特性是:溴替代体能增强反应性能,使诸如Suzuki或Buchwald-Hartwig等高效的交叉反应能够进一步实现功能化.其硬性引信环环系系统有助于稳定的分子相互作用,使其在动脉抑制剂和其他治疗剂的开发中具有价值.该化合物的特点是高纯度和连续性,确保合成应用的可靠性.建议在惰性条件下进行适当的处理,因为其敏感性.

英文名称5-Bromo-1H-Pyrazolo[3,4-B]Pyridine
中文名称5-溴-1H-吡唑并[3,4-b]吡啶
IUPAC名称5-bromo-2H-pyrazolo[3,4-b]pyridine
其它别名5-Bromo-1H-Pyrazolo [3,4-B]Pyridine; 5-Bromo-1H-Pyrazolo3,4-Bpyridine; 5-Bromo-7-Azaindazole; 5-Bromo-1H-Pyrazolo[3,4-B]Pyridine; 5
CAS编号875781-17-2
MFCD编号:MFCD05663982
EINECS号:807-974-3
分子式:C6H4BrN3
分子量:198.02
产品CID: 1883688
产品分类香精与香料 → 合成香料 → 内酯和含氧杂环化合物

相似结构搜索
InChIKey: BASYLPMLKGQZOG-UHFFFAOYSA-N
InChI=1S/C6H4BrN3/c7-5-1-4-2-9-10-6(4)8-3-5/h1-3H,(H,8,9,10)…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
警示词Warning(警告)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
防范说明P261-P280a-P304+P340-P305+P351+P338-P405-P501a
危险等级IRRITANT
UN编号NONH for all modes of transport
危险品标志Xn
安全声明24/25
危险类别码22
WGK Germany3.0

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 5-Bromo-1H-Pyrazo[3,4-B]Pyridine 主要起始原料 5-Bromo-2-Fluoropyridine-3-Carboxaldehyde
(文献来源)合成步骤主要原料 5-Bromo-2-Fluoropyridine-3-Carboxaldehyde

在盐酸,Sodium Carbonate体系中,用乙醇,水作为反应溶剂,化学反应 16.0H,以50%的收率获得产物5-溴-1H-吡唑[3,4-B]吡啶
参考文献: Fused Ring Heterocycle Kinase Modulators[fr] Modulateurs Heterocycliques A Cycles Fusionnes Pour Les Kinases
标题: Fused Ring Heterocycle Kinase Modulators[fr] Modulateurs Heterocycliques A Cycles Fusionnes Pour Les Kinases

海关参考信息

2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2012077802-A1
优先权日:2009-06-10
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are spiro-cyclic compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

专利号:WO-2024233563-A1
优先权日:2023-05-09
标题:6,6-fused bicyclic amides and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; AMEGADZIE ALBERT K; BOURBEAU MATTHEW P; LI KEXUE
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a structure of Formula (I): or a pharmaceutically acceptable salt thereof; wherein is Formula (i) or Formula (ii) Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-2024409557-A1
优先权日:2023-05-09
标题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-7772246-B2
优先权日:2007-08-01
标题:Pyrazole compounds as RAF inhibitors
发明人：CUI JINGRONG JEAN; DEAL JUDITH GAIL; GU DANLIN; GUO CHUANGXING; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; KEPHART SUSAN ELIZABETH; LINTON MARIA ANGELICA; MCALPINE INDRAWAN JAMES; PAIRISH MASON ALAN; PALMER CYNTHIA LOUISE
权利人:PFIZER
摘要:The present invention is directed to compounds of Formula (I), n nand to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.

专利号:CN-103980272-B
优先权日:2014-04-18
标题:A kind of method of synthesis 5-cyano group-1H-pyrazolo [3,4-b] pyridine