CAS: 86788-49-0; Methyl 7-Hydroxy-2-Oxo-2H-Chromene-3-Carboxylate
- 英文名称Methyl 7-Hydroxy-2-Oxo-2H-Chromene-3-Carboxylate
- 中文名称7-羟基-2-氧代-2H-色烯-3-羧酸甲酯
- IUPAC名称methyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate
- 其它别名7-羟基-2-氧代-2H-苯并吡喃-3-甲酸甲酯; 7-Hydroxycoumarin-3-Carboxylic Acid Methyl Ester
- CAS编号86788-49-0
- MFCD编号:MFCD00488484
- 分子式:C11H8O5分子量:220.18
- 产品CID: 1871020
- 产品分类有机原料→分子砌块→芳杂环类化合物→香豆素类化合物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: UDRWUSXZHQTTEN-UHFFFAOYSA-N
- InChI=1S/C11H8O5/c1-15-10(13)8-4-6-2-3-7(12)5-9(6)16-11(8)14/h2-5,12H,1H3
- 计算化学: 氢键受体数5.0氢键供体数1可旋转键数1
MSDS等安全信息
上下游产品
7-羟基香豆素-3-羧酸乙酯 7-Hydroxy-2-Oxo-2H-Chromene-3-Carboxylic Acid Ethyl Ester 6093-71-67-羟基香豆素-3-羧酸 7-Hydroxy-2-Oxo-2H-Chromene-3-Carboxylic Acid 779-27-1
合成工艺路线路线简述
- 合成目标产物 7-Hydroxy-2-Oxo-2H-Chromene-3-Carboxylic Acid Methyl Ester 主要起始原料 Dimethyl Malonate And 2,4-Dihydroxybenzaldehyde
- (文献来源)合成步骤主要原料 Dimethyl Malonate 和 2,4-Dihydroxybenzaldehyde
📜7-羟基香豆素-3-羧酸乙酯置于盐酸,水,Sodium Hydroxide体系中,化学反应 12.0H,反应生成 7-羟基-2-氧代-2H-苯并吡喃-3-甲酸甲酯
参考文献:香豆素衍生物作为蘑菇酪氨酸酶抑制剂的生物学评价
标题:香豆素衍生物作为蘑菇酪氨酸酶抑制剂的生物学评价
摘要:合成了一系列香豆素衍生物,并评价了它们对蘑菇酪氨酸酶双酚酶活性的抑制作用.结果表明,某些合成的化合物表现出显着的抑制活性.尤其是带有巯基-氨基脲基的2-(1-(香豆素-3-基)亚乙基)肼甲硫代酰胺对ic 50的酪氨酸酶抑制作用最强.值为3.44μm.对2-(1-(香豆素-3-基)-亚乙基)肼甲硫代酰胺和2-(1-(6-氯香豆素-3-基)亚乙基)-肼甲硫代酰胺的抑制机理分析表明,该化合物对甲壳素具有抑制作用.酪氨酸酶是不可逆的.初步结构活性关系(sar)分析表明,此类化合物的进一步开发可能会引起人们的兴趣.
DOI:10.1016/j.Foodchem.2012.07.055
海关参考信息
- 2912110000-甲醛
2915110000-甲酸
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10561681-B2
优先权日:2016-07-21
标题 :Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents
发明人：ARSENJANS PAVELS; VASILJEVA JELENA; DOMRACHEVA ILONA; SHESTAKOVA IRINA; KALVINS IVARS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to a novel cancer metastasis preventing and curing selenopheno[h]chromene derivatives, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment and/or prevention of primary cancer and its metastasis by administration of such substances.
专利号:BR-112018073219-B1
优先权日:2016-07-21
标 题 :COMPOUND OF FORMULA I, PHARMACEUTICAL COMPOSITION, PROCESS FOR THE SYNTHESIS OF THESE COMPOUNDS AND USE OF THE SAME
专利号:US-2019298758-A1
优先权日:2016-07-21
标题:Antimetastatic 2H-Selenopheno[3,2-h]chromenes, Synthesis Thereof, and Methods of Using Same Agents
专利号:WO-2018015788-A1
优先权日:2016-07-21
标题:ANTIMETASTATIC 2H-SELENOPHENO[3,2-h]CHROMENES, SYNTHESIS THEREOF, AND METHODS OF USING SAME AGENTS
专利号:JP-2019523230-A
优先权日:2016-07-21
标 题:Anti-metastatic 2H-selenopheno [3,2-h] chromene, their synthesis, and methods of using the same
专利号:ES-2849153-T3
优先权日:2016-07-21
标 题:2H-Selenophene [3,2-h] antimetastatic chromenes, synthesis thereof, and methods of use of such agents
