CAS: 7764-95-6; Boc-D-Ala-Oh

相似化合物

1142-20-7 15761-38-3 16948-16-6

上下游产品

tert-Butyl 4-nitrophenyl carbonate rac-Ala-OH tert-butyl alcoholtert-butyl alcohol N-tert-butoxycarbonyl-DL-alanine (SR)-3-oxo-2-trityl-isoxazolidin-4-ylamideN-tert-butoxycarbonyl-DL-alanine (SR)-3-oxo-2-trityl-isoxazolidin-4-ylamide N-tert-butoxycarbonyl-DL-alanine (RS)-3-oxo-2-trityl-isoxazolidin-4-ylamideN-tert-butoxycarbonyl-DL-alanine (RS)-3-oxo-2-trityl-isoxazolidin-4-ylamide R)-3-benzyl-7t-[(N-tert-butoxycarbonyl-D-alanyl)-amino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid tert-butyl ester(6R)-3-benzyl-7t-[(N-tert-butoxycarbonyl-D-alanyl)-amino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid tert-butyl ester

(R)-1-Benzyloxy-N-Tert-Butoxycarbonyl-2-Propylamine置于palladium Dihydroxide Ruthenium Trichloride,Sodium Periodate,氢气体系中,用 甲醇,四氯化碳,水,乙腈 作为反应溶剂,化学反应 5.0H,反应生成 Boc-D-丙氨酸
参考文献:Synthesis Of Chiral α-Amino Acids
标题:Synthesis Of Chiral α-Amino Acids
摘要:A Novel Method For The Synthesis Of Chiral Alpha-Amino Acids Has Been Developed Where The Acid Functionality Was Constructed By Oxidizing A Hydroxymethyl Group Introduced By Evans' Method In The Alpha-Position Of An Appropriate Acid Substrate And The Amino Part Came From The Amide Of The Original Carboxyl Group Following A Modified Hofmann Rearrangement Reaction. (C) 2002 Published By Elsevier Science Ltd.
DOI:10.1016/s0040-4039(02)02433-4

专利信息

专利号:WO-2023030277-A1
优先权日:2021-08-30
标 题:Method for fully liquid-phase synthesis of grnh nonapeptide amide analog
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN MICRO PEPTIDE BIOMEDICAL CO LTD
摘要:Provided is a method for fully liquid-phase synthesis of a GRnH nonapeptide amide analog, which belongs to the technical field of medicine synthesis. The method comprises respectively synthesizing a 'Trp-Ser-Tyr' fragment, an 'R-Leu' fragment, a 'Pyr-His' fragment and 'Arg-Pro-Hunan T', wherein, R = D-Ala (alarelin), D-Leu (leuprorelin), D-Trp (deslorelin) and D-His (histrelin), and obtaining the GRnH nonapeptide amide analog with high yield and high purity by means of a '3 +2 +2 +2' fragment condensation method. The synthesis method is environmentally friendly, mild, and free of any highly toxic and poisonable reagents. The cost is greatly reduced and the synthesis method is very suitable for large-scale production.

专利号:US-5026773-A
优先权日:1987-03-11
标 题 :Apparatus for a solid phase synthesis of peptide analogs
发明人：STEEL SAMUEL
权利人:STEEL SAMUEL
摘要:A novel polymeric disc, wafer or similarly shaped resin for carrying out the synthesis of peptide analogs via solid phase peptide synthesis techniques is provided. The polymeric disc or wafer of the invention may be made out of those resin materials presently used in bead form in solid phase peptide synthesis, such as, benzhydrylamine resins, Boc-aminoacyl-4-(oxymethyl)-phenyacetamidomethyl (Pam) resin, polyamide resins and chloromethyl resins. The disc or wafer of the invention should, preferably, have a thickness of 200-400 mu m and may be of any suitable length or width. A process for the synthesis of peptide analogs utilizing the polymeric disc or wafer of the present invention is also disclosed.

专利号:US-4396542-A
优先权日:1980-02-14
标 题 :Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
发明人：WENGER ROLAND
权利人:SANDOZ LTD
摘要:A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.

专利号:US-5212288-A
优先权日:1990-02-20
标 题:Temporary minimal protection synthesis of serine-containing polypeptides
发明人：NESTOR JR JOHN J; MCCLURE NATALIE L; ARZENO HUMBERTO
权利人:SYNTEX INC
摘要:In a process for the solid phase synthesis of a polypeptide containing at least one serine residue, the improvement comprising temporarily protecting the side chain of the serine residue with a protecting group which is removed immediately following the addition of the serine to the peptide chain.

专利号:US-4554351-A
优先权日:1980-02-14
标 题:Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
发明人：WENGER ROLAND
权利人:SANDOZ LTD
摘要:A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.

专利号:US-2017320908-A1
优先权日:2014-11-19
标题 :Solid phase synthesis of cyclic amino acid molecules
发明人：HICKEY JENNIFER L; MANCUSO JOHN; MARSAULT ERIC; ROUGHTON ANDREW L; TREDER ADAM P; TREMBLEY MARIE-CLAUDE J; YUDIN ANDREI K; ZARETSKY SERGE
权利人:ENCYCLE THERAPEUTICS; GOVERNING COUNCIL OF THE UNIV OF TORONTO; UNIV SHERBROOKE
摘要:The present invention relates to cyclic amino acid molecules and methods of preparing the same, and in particular the macrocyclization of amino acids or linear peptides bound to a solid support.