CAS: 7498-57-9; 2-Naphthylacetonitrile

上下游产品

CAS号143-33-9 氰化钠 | CAS号939-26-4 2-(溴甲基)萘 | CAS号581-96-4 2-萘乙酸 | CAS号37859-25-9 2-(2-萘基)乙酰氯 | CAS号1295629-84-3 4-(2-naphthyl)i... | CAS号928664-98-6 4-异恶唑硼酸频哪醇酯 | CAS号612-55-5 2-碘萘 | CAS号91-58-7 β-氯萘 | CAS号109220-61-3 1,2,3,4-tetrahy... | CAS号2017-67-6 2-(2-萘基)乙胺 盐酸盐 | CAS号2876-71-3 2-萘乙酸甲酯 | CAS号581-96-4 2-萘乙酸 | CAS号3582-43-2 α-[2-(Dimethyla... | CAS号3582-42-1 α-[2-(Dimethyla... | CAS号3582-41-0 α-[2-(Dimethyla... | CAS号93-04-9 2-萘甲醚 | CAS号1363650-08-1 α-(2-methoxynap... | CAS号2017-68-7 2-氨乙基萘

2-甲基萘置于n-溴代丁二酰亚胺(Nbs),Sodium Carbonate,过氧化苯甲酰体系中,用 四氯化碳,乙醇,水 作为反应溶剂,化学反应 16.0H,反应生成 2-萘乙腈
参考文献:N-酰氧基-N-烷氧基酰胺的 致突变性,作为dna嵌入的指示剂第1部分:萘作为dna嵌入剂的证据†
标题:N-酰氧基-N-烷氧基酰胺的 致突变性,作为dna嵌入的指示剂第1部分:萘作为dna嵌入剂的证据†
摘要:N-酰氧基-N-烷氧基酰胺是鼠伤寒沙门氏菌ta100中的直接作用诱变剂,对log P具有线性依赖性,在log P 0 = 6.4时最大.已证明在三个侧链的任何一个上带有萘基且log P 0 <6.4的八种n-酰氧基-N-烷氧基酰胺(2-9) 对鼠伤寒沙门氏菌ta100的致突变性均比50个诱变剂均匀得多.没有萘.2-9的活动增强可能是由于萘与细菌dna的插入结合,因为ta98是鼠伤寒沙门氏菌的移码菌株,也被插入剂修饰,在ta98中也有许多活性.带有萘的诱变剂的dna损伤特征证实了掺入萘后与dna的反应性增强,并且与不含萘的诱变剂相比具有不同的结合方式.该效果与萘是否连接至供电子的烷基或吸电子的酰基,烷基系链长度或(在6和7的情况下)萘的连接点无关.已为所有58个同类物构建了新的定量结构活性关系,其中包括对数 P和指标变量,I,对于萘的存在(i = 1)或不存在(i = 0),从中可以量化出萘的活性增强作用在三个和四个log
DOI:10.1039/c6Ob00162A

专利信息

专利号:US-12187664-B2
优先权日:2019-10-29
标题:High purity 2-naphthylacetonitrile and method for producing same
发明人：NAGAHAMA MASAKI; OKADO DAIKI; TANIIKE HIROTSUGU
权利人:API CORP
摘要:High purity 2-naphthylacetonitrile with fewer impurities that is useful as a starting material or intermediate for the synthesis of various pharmaceutical products, agricultural chemicals, and chemical products, and a production method thereof. A high purity 2-naphthylacetonitrile having an HPLC purity of 2-naphthylacetonitrile of not less than 95 area %, and containing naphthalene compounds represented by the formulas (a)-(j) at a content of a predetermined area % or below. A method for producing high purity 2-naphthylacetonitrile.

专利号:US-9868718-B2
优先权日:2006-01-06
标 题 :Cycloalkylamines as monoamine reuptake inhibitors
发明人：SHAO LIMING; WANG FENGJIANG; MALCOLM SCOTT CHRISTOPHER; HEWITT MICHAEL CHARLES; BUSH LARRY R; MA JIANGUO; VARNEY MARK A; CAMPBELL UNA; ENGEL SHARON RAE; HARDY LARRY WENDELL; KOCH PATRICK; CAMPBELL JOHN E
权利人:SUNOVION PHARMACEUTICALS INC
摘要:The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

专利号:CN-104744322-B
优先权日:2013-12-27
标 题:A kind of chiral thioene ligand, synthesis method and its application in asymmetric reaction