CAS: 7443-52-9; Trans-2-Methylcyclohexanol

该化合物是一种有机化合物,分类为循环酒精;它有一个环环环,有甲基组和氢氧(OH),放置在相邻的碳原子上,具体地说,是一个跨式结构结构,影响其物理和化学特性,包括其沸点,熔点和溶性.通常,跨-2-Mecyclohohexanol是一种无色液体,具有独特的气味,并且由于存在可形成氢结的氢氧基组,该化合物在水中可中溶解.该化合物主要用于有机合成,并作为中间体用于生产各种化学品,其再活动包括典型的酒精反应,如氧化和酯化.安全数据表明,与许多酒精一样,它应谨慎处理,因为它在接触皮肤或眼睛时可能引起刺激.适当的储存和处理程序对于确保实验室和工业环境中的安全至关重要.

结构式图片

相似化合物

583-60-8 15963-35-6 583-59-5

欧盟法规

统一分类与标签ECHA物质ECHA物质工作场所安全标识要求C&L通报REACH预注册废弃物危险特性清单

上下游产品

CAS号591-49-1 1-甲基-1-环己烯 | CAS号83511-24-4 (1R,2S)-2-methy... | CAS号75-24-1 三甲基铝 | CAS号286-20-4 环氧环己烷 | CAS号583-59-5 2-甲基环己醇 | CAS号95-48-7 邻甲酚 | CAS号85288-01-3 trimethyl(((1R,... | CAS号75732-55-7 1-mercaptotetra... | CAS号583-60-8 2-甲基环己酮 | CAS号55860-92-9 (2-methyl-1-cyc... | CAS号4423-94-3 2-乙基环己酮 | CAS号69854-63-3 2-ethylcyclohex... | CAS号14962-11-9 1-甲基-3-(1-甲基-环己基)-苯 | CAS号591-49-1 1-甲基-1-环己烯 | CAS号591-48-0 3-甲基-1-环己烯 | CAS号931-78-2 1-氯-1-甲基环己烷 | CAS号591-47-9 4-甲基-1-环己烯 | CAS号5726-19-2 2-甲基环己基醋酸酯

合成工艺路线路线简述

  • 108-87-2 = 7443-52-9 + 96184-81-5 + 69814-26-2 + 7731-28-4 + 5454-79-5 + 7443-55-2 + 7443-70-1 + 2043-61-0 + 100-49-2 + 590-67-0 + 7731-29-5 + 1193-63-1
    反应条件:1.1 Reagents: Hydrogen Peroxide,Oxygen Catalysts: Nitric Acid,Sodium,[μ13-[1,15-Bis[[di(Hydroxy-Ko:Ko)Phenylsilyl]Oxy-Ko]-1,3,5,7,9,11,13,15-... Solvents: Acetonitrile
    标题:A Heterometallic (Fe6Na8) Cage-Like Silsesquioxane: Synthesis,Structure,Spin Glass Behavior And High Catalytic Activity
    作者:Bilyachenko,Alexey N.; Levitsky,Mikhail M.; Yalymov,Alexey I.; Korlyukov,Alexander A.; Vologzhanina,Anna V.; Et Al
    参考文献:Rsc Advances 日期:2016 卷标:6(53) 页码:48165-48180
📜3-甲基-1-环己烯 在 2-(Perfluorooctyl)Ethyl Methyl Sulfide*bh3,Sodium Hydroxide,双氧水体系中,用 二氯甲烷,水作为反应溶剂,反应 1.0H,以91%的收率获得(+/-)-Trans-2-Methylcyclohexanol
参考文献:氟二甲基硫醚:一种方便,无味,可回收的硼烷载体.
标题:氟二甲基硫醚:一种方便,无味,可回收的硼烷载体.
摘要:硼烷气体和2-(全氟辛基)乙基甲基硫化物形成固体,该固体由硫化物和相应的硫化物-硼烷的大约1:1混合物(氟bms)组成.氟bms允许烯烃在二氯甲烷/全氟化烃混合物中进行硼氢化,随后通过氟萃取回收氟硫化物.还报道了氟代bms在通过手性氧杂硼烷催化剂催化的酮的不对称还原中以及在其他官能团的还原中的用途.[反应:看文字]
Doi:10.1021/Ol026957J

海关参考信息

专利信息


专利号:US-6555686-B2
优先权日:2000-03-23
标题:Asymmetric synthesis of quinazolin-2-ones useful as HIV reverse transcriptase inhibitors
发明人:PARSONS RODNEY L; DOROW ROBERTA L; DAVULCU AKIN H; FORTUNAK JOSEPH M; HARRIS GREGORY D; KAUFFMAN GOSS S; NUGENT WILLIAM A; RADESCA LILIAN A
权利人:BRISTOL MYERS SQUIBB PHARMA
摘要:This invention relates generally to the asymmetric synthesis of quinazolin-2-ones that are useful as inhibitors of HIV reverse transcriptase. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.

专利号:US-8618311-B2
优先权日:2005-06-15
标题:Synthetic processes for the preparation of aminocyclohexyl ether compounds
发明人:JUNG GRACE; YEE JAMES GEE KEN; CHOU DOUG TA HUNG; PLOUVIER BERTRAND M C
权利人:JUNG GRACE; YEE JAMES GEE KEN; CHOU DOUG TA HUNG; PLOUVIER BERTRAND M C; CARDIOME PHARMA CORP
摘要:This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): n nor a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R 3 , R 4 and R 5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.

专利号:US-6960601-B2
优先权日:2001-09-24
标题 :Preparation and use of imidazole derivatives for treatment of obesity
发明人:SMITH ROGER A; O'CONNOR STEPHEN J; WIRTZ STEPHAN-NICHOLAS; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C E; SU NING; WANG GAN; ACHEBE FURAHI; YING SHIHONG
权利人:BAYER PHARMACEUTICALS CORP
摘要:This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:US-10759899-B2
优先权日:2017-08-03
标题 :Recyclable polymers based on ring-fused gamma-butyrolactones
发明人:CHEN EUGENE Y; Zhu jian-bo
权利人:UNIV COLORADO STATE RES FOUND
摘要:The invention discloses a class of new polymers, trans-ring-fused poly(4-hydroxybutyrate)s (RF-P4HB) that exhibit a unique set of properties, including robust thermal stability and mechanical strength, quantitative recyclability to the building block monomers via thermolysis and/or chemical catalysis, and convenient production from the chemical ring-opening polymerization under ambient temperature and pressure. Another unique property is the formation of crystalline stereocomplexed polymers with high melting temperature upon mixing the two enantiomeric RF-P4HB chains via stereocomplexing co-crystallization. This invention also provides the corresponding ring-fused lactone monomer structures that enable the synthesis of the RF-P4HB polymers, through trans-fusing of rings to the parent γ-butyrolactone ring. Furthermore, a polymerization or copolymerization process for the synthesis of RF-P4HB polymers and copolymers is disclosed.

专利号:US-8129411-B2
优先权日:2005-12-30
标题:Organic compounds
发明人:EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI
权利人:EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. n The compounds have the formula I′ n nwherein R1, R2, T, R3 and R4 are as defined in the specification.

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Alexander L Perryman, Et Al. Fragment-Based Screen Against Hiv Protease. Chem Biol Drug Des. 2010 Mar;75(3):257-68.

合成参考文献


摘要:Kostikov, R. R.; Khlebnikov, A. F.; Sokolov, V. V., Science of Synthesis, (2010) 47, 816.
摘要:Bertau, M.; Jeromin, G. E., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 164.
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