CAS: 70500-72-0; 7-Hydroxyquinolin-2(1H)-One

上下游产品

CAS号15116-41-3 (E)-BETA-FARNESENE | CAS号127033-74-3 N-(肉桂酰基)-3-甲氧基苯胺 | CAS号591-27-5 间氨基苯酚 | CAS号93-35-6 伞形花内酯； 7-羟基香豆素 | CAS号536-90-3 间氨基苯甲醚 | CAS号111073-34-8 7-[3-[4-(2,3-di... | CAS号1076199-59-1 7-(3-BROMOPROPO... | CAS号129722-25-4 7-[4-[4-(2,3-二氯... | CAS号203395-59-9 7-(4-溴丁氧基)-2(1H)喹啉酮 | CAS号79145-59-8 7-(3-chloroprop...

3-氨基苯酚置于aluminum (Iii) Chloride,碳酸氢钠,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 四氢呋喃,二氯甲烷,N,N-二甲基乙酰胺 作为反应溶剂,化学反应 9.5H,反应生成 7-羟基-2-喹诺酮
参考文献:An Innovative Approach For The Synthesis Of 7-Hydroxyquinolin-2(1H)-One: A Key Intermediate Of Brexpiprazole
标题:An Innovative Approach For The Synthesis Of 7-Hydroxyquinolin-2(1H)-One: A Key Intermediate Of Brexpiprazole
摘要:2,3-二氯-5,6-二氰基-对苯醌 (Ddq) 介导的 7-羟基-1,2,3,4-四氢-2-喹啉酮氧化反应由 3-羟基苯胺制备得到 7-水介质中的羟基喹啉-2(1H)-酮.化学计量的 Ddq 和 Thf 可提供高产量的 7-羟基喹啉-2(1H)-酮,并减少有机溶剂的消耗并减少副产物的产生.这种方法的总体优势是缩短了brexpiprmaze中间体的时间周期和成本.
DOI:10.14233/ajchem.2018.21092

专利信息

专利号:US-9670230-B2
优先权日:2012-11-29
标题 :Heteroaryl compounds and methods of use thereof
发明人：CAMPBELL JOHN EMMERSON; JONES PHILIP
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

专利号:WO-2008144764-A1
优先权日:2007-05-21
标 题 :Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents

专利号:AU-2008254585-B2
优先权日:2007-05-21
标 题:Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents

专利号:US-2008293736-A1
优先权日:2007-05-21
标 题:Compositions, Synthesis, and Methods of Using Quinolinone Based Atypical Antipsychotic Agents

专利号:US-8247420-B2
优先权日:2007-05-21
标 题:Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents
发明人：BHAT LAXMINARAYAN; MOHAPATRA PRABHU P; BHAT SEEMA RANI
权利人:BHAT LAXMINARAYAN; MOHAPATRA PRABHU P; BHAT SEEMA RANI; REVIVA PHARMACEUTICALS INC
摘要:The present invention provides novel quinolinone derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder, and depression.

专利号:AU-2008254585-A1
优先权日:2007-05-21
标 题 :Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents