CAS: 59887-89-7; 7-Hydroxy-4-Chromone

上下游产品

CAS号89-84-9 2',4'-二羟基苯乙酮 | CAS号122-51-0 原甲酸三乙酯 | CAS号5751-52-0 7-甲氧基-4H-色烯-4-酮 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号552-41-0 丹皮酚 | CAS号30113-83-8 7-hydroxy-4-oxo... | CAS号108982-01-0 7-benzyloxy-4-o... | CAS号6345-73-9 4H-1-Benzopyran... | CAS号860189-36-2 4-(4-benzyloxy-... | CAS号105277-69-8 7-(3-chloroprop... | CAS号6515-36-2 7-羟基黄烷酮 | CAS号76240-27-2 7-羟基色满-4-酮 | CAS号57052-72-9 苯并二氢吡喃-7-醇

📜丹皮酚置于盐酸,Sodium,三溴化硼,溶剂黄146体系中,用 二氯甲烷 作为反应溶剂,化学反应 36.5H,反应生成 7-羟基色原酮
参考文献:酰基辅酶a:胆固醇酰基转移酶的有效抑制剂.新型n-(4-氧代苯并吡喃-8-基)酰胺的结构活性关系.
标题:酰基辅酶a:胆固醇酰基转移酶的有效抑制剂.新型n-(4-氧代苯并吡喃-8-基)酰胺的结构活性关系.
摘要:合成了新型n-(4-氧代苯并二氢吡喃-8-基)酰胺衍生物1并测试了它们在体外抑制兔小肠acat(酰基-Coa:胆固醇酰基转移酶)并降低胆固醇喂养大鼠血清总胆固醇的能力.体内.在合成的化合物中,N-(7-烷氧基-4-氧代苯并吡喃-8-基)酰胺衍生物在体外和体内均显示出有效的acat抑制活性.在这两种测定的基础上,讨论了这些n-(4-氧代苯并吡喃-8-基)酰胺和相关化合物的构效关系.4-苯并二氢吡喃酮第4位的羰基对于有效的acat抑制活性至关重要.n-(色胺基-8-基)衍生物的效力不如n-(4-氧代色烷-8-基)衍生物.4-苯并二氢吡喃酮部分第7位的烷氧基对于有效的acat抑制活性很重要.在n-(7-烷氧基-4-氧代苯并二氢吡喃-8-基)酰胺衍生物中,引起有效acat抑制活性的另一个必要因素是分子的亲脂性.高度亲脂性酰胺n-(7-甲氧基-4-氧代苯并吡喃-8-基)-2,2-二甲基十二烷酰胺(3
DOI:10.1021/jm00016A021

专利信息

专利号:WO-2025125811-A1
优先权日:2023-12-12
标题:Heterocyclic compounds and their use for the treatment of neurological disorders
发明人：PLOWRIGHT ALLEYN THOMAS; PFEIFFER THOMAS; MÄRCHER-RØRSTED EMIL; DUCKWORTH EDWARD JOSEPH
权利人:ONTRACK THERAPEUTICS LTD
摘要:The present invention relates to novel synthetic compounds of Formula (I) and (II) related to naturally occurring flavonoids such as 7,8-dihydroxyflavone (7,8-DHF). The invention further relates to the method of synthesis, the use of these compounds as research tools and their use as pharmaceuticals.

专利号:US-9382224-B2
优先权日:2011-01-21
标题 :7-acyloxychromen-4-one derivatives and the use thereof as self-tanning substances
发明人：CAROLA CHRISTOPHE; SCHEURICH RENE PETER
权利人:CAROLA CHRISTOPHE; SCHEURICH RENE PETER; MERCK PATENT GMBH
摘要:The present invention relates to chromen-4-one derivatives of the formula (I), to the use thereof as self-tanning substance or for increasing melanin synthesis, improving melanin transport and/or improving the distribution of melanin in suprabasal layers, and to preparations comprising these chromen-4-one derivatives.