CAS: 51997-51-4; 4-Glycidyloxycarbazole

上下游产品

CAS号52602-39-8 4-羟基咔唑 | CAS号106-89-8 环氧氯丙烷 | CAS号3132-64-7 环氧溴丙烷 | CAS号143412-40-2 (S)-1-氨基-3-(9h-... | CAS号918903-20-5 卡维地洛杂质B | CAS号72956-09-3 卡维地洛 | CAS号787598-91-8 (+/-)-1-(9H-car... | CAS号72955-94-3 N-苄基卡维地洛 | CAS号1253696-17-1 4-[1'-(3'-叠氮基-1... | CAS号1198090-73-1 卡维地洛杂质1 | CAS号69-72-7 水杨酸 | CAS号72956-44-6 O-去甲卡维地洛

环氧氯丙烷置于sodium Dithionite,Potassium Carbonate,Potassium Iodide体系中,用 丙酮 作为反应溶剂,化学反应 33.0H,以69.9%的收率获得产物4-环氧丙烷氧基咔唑
参考文献: Process For The Preparation Of Carvedilol Form-Ii[fr] Procede De Fabrication De Carvedilol,Forme-Ii
标题: Process For The Preparation Of Carvedilol Form-Ii[fr] Procede De Fabrication De Carvedilol,Forme-Ii
摘要:本发明提供了一种成本效益高,在工业上可行的过程,用于制备结晶的卡维地洛ⅱ型,该过程使用包含与2-(2-甲氧基苯氧基)乙基胺(Iii)反应的4-(2,3-环氧丙氧基)咔唑(II)的新型卡维地洛盐,然后在有机溶剂存在下与矿酸反应酸化,得到酸加盐,用碱在有机溶剂和水的存在下处理所述盐,然后从有机溶剂中分离,最后从乙酸乙酯中结晶.

专利信息

专利号:US-2007197797-A1
优先权日:2005-12-30
标 题 :Compounds and methods for carbazole synthesis
发明人：HARRINGTON PETER J
权利人:HARRINGTON PETER J
摘要:Compounds having bi-cyclic structure comprising a partially unsaturated 6-carbon first cyclic moiety interconnected to a 6-carbon second cyclic moiety second via a divalent linking moiety are provided. The compounds can be used as intermediates compounds in methods for the synthesis of carbazoles and derviatives thereof, including carvedilol, and tricyclic alkylhydroxamates, which do not require Fischer indole synthetic steps. Methods of preparing the compounds having bi-cyclic structures are also provided.

专利号:US-7534895-B2
优先权日:2002-11-08
标 题:Process for preparation of carvedilol
发明人：HERCEK RICHARD; SKODA ALOJZ; PROKSA BOHUMIL
权利人:ZENTIVA AS
摘要:The invention solves a new method of preparation of Carvedilol for pharmaceutical use. In the synthesis of Carvedilol a reaction of 4-(oxirane-2-ylmethoxy)-9H-arbazole (II) with 2-(2-methoxyphenoxy)ethylamine salts (IV) in the presence of a base, in an alcohol having the number of carbons C2 to C5 as a solvent, at an elevated temperature, is used. After processing of the crude reaction mixture crude Carvedilol is obtained, which is purified by crystallization from ethylacetate with an addition of activated carbon and the final substance is formulated by crystallization from ethylacetate.

专利号:WO-2009157015-A8
优先权日:2008-06-04
标 题 :Synthesis of 1-(carbazol-4-yloxy)-3-[[2-(o- methoxyphenoxy)ethyl]amino]-2-propanol
发明人：RAY PURNA CHANDRA; LAKONDA NAGAPRASADA RAO; SATYENDER APURI; REDDY R BUCHI
权利人:INOGENT LAB PRIVATE LTD; RAY PURNA CHANDRA; LAKONDA NAGAPRASADA RAO; SATYENDER APURI; REDDY R BUCHI
摘要:The present invention relates to an improved process for the preparation of Carvedilol, wherein, the process involves the use of organic base in the reaction of 4-(oxirane-2ylmethoxy)-9H-carbazole with 2-(2-methoxyphenoxy) ethylamine in presence of a solvent. While preparing Carvedilol minimum amount of bis-impurity was obtained without purification.

专利号:EP-1375474-B1
优先权日:2000-05-18
标 题 :Intermediate for the preparation of carvedilol
发明人：PITTELKOW THOMAS; FISCHER ERIK; TREPPENDAHL SVEND PETER
权利人:GEA FARMACEUTISK FABRIK AS
摘要:A new intermediate having the formula (VI) wherein X and Y are leaving groups; is disclosed. The new intermediate is useful for the preparation of carvedilol in a synthesis that avoids the use of any oxirane or similar hazardous reacgents.

专利号:WO-2009157015-A3
优先权日:2008-06-04
标题:Synthesis of l-(carbazol-4-yloxy)-3-[[2-(o- methoxyphenoxy)ethyl]amino]-2-propanol

专利号:WO-2009157015-A2
优先权日:2008-06-04
标题:Synthesis of 1-(carbazol-4-yloxy)-3-[[2-(o- methoxyphenoxy)ethyl]amino]-2-propanol