CAS: 51067-85-7; Methyl 2-Hydroxydodecanoate

上下游产品

1,1,1-tris(methylthio)-2-dodecanol undecylaldehyde 2-methoxy-dodecanoic acid methyl ester

📜十一醛置于正丁基锂,Mercury Dichloride,Mercury(II) Oxide体系中,用 四氢呋喃,甲醇,正己烷 作为反应溶剂,化学反应 2.25H,反应生成 2-羟基十二烷酸甲酯
参考文献:通过三(甲硫基)甲烷离子与烷醛的加成反应合成 S-甲基 2-羟基链烷硫酸酯,2-羟基链烷酸和相关化合物
标题:通过三(甲硫基)甲烷离子与烷醛的加成反应合成 S-甲基 2-羟基链烷硫酸酯,2-羟基链烷酸和相关化合物
摘要:结合myrmicacin及相关化合物的生物活性研究,研究了2-羟基链烷酸及其相应的1,2-二醇的合成方法.三(甲硫基)甲基锂与醛(丙醛-十二醛)的加成反应得到相应的 1,1,1-三(甲硫基)-2-烷醇 1A-J.在水-丙酮中用氯化汞(II)-氧化汞(II)处理 1 得到 S-2-羟基链烷硫代酸甲酯 2A-J,在甲醇中得到 2-羟基链烷酸甲酯 3C-J.用氢化铝锂还原硫代物 2 得到 1,2-二醇 4C-J,皂化产生相应的 2-羟基链烷酸 5C-J.
DOI:10.1246/bcsj.62.2013

专利信息

专利号:US-8329958-B2
优先权日:2004-07-02
标 题:Combinatorial synthesis of PEG oligomer libraries
发明人：RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N
权利人:RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N; BIOCON LTD
摘要:A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.

专利号:US-2014256904-A1
优先权日:2011-08-15
标 题:Biotechnological synthesis process of omega-functionalized carbon acids and carbon acid esters from simple carbon sources
发明人：SCHAFFER STEFFEN; DECKER NICOLE; GIELEN JASMIN; HAEGER HARALD; HAAS THOMAS; POETTER MARKUS; HENNEMANN HANS-GEORG; WESSEL MIRJA; VOLLAND MICHAEL
权利人:SCHAFFER STEFFEN; DECKER NICOLE; GIELEN JASMIN; HAEGER HARALD; HAAS THOMAS; POETTER MARKUS; HENNEMANN HANS-GEORG; WESSEL MIRJA; VOLLAND MICHAEL; EVONIK DEGUSSA GMBH
摘要:The subject of the invention is a biotechnological process for the production of ω-functionalized carboxylic acids and of ω-functionalized carboxylate esters from simple carbon sources.

专利号:US-2006008850-A1
优先权日:2004-07-02
标 题 :Combinatorial synthesis of PEG oligomer libraries

专利号:CN-103857793-A
优先权日:2011-08-15
标 题:Biotechnological process for the synthesis of omega-functionalized carboxylic acids and esters from simple carbon sources

专利号:US-6503711-B1
优先权日:1997-06-18
标题:Nucleic acid biosensor diagnostics
发明人：KRULL ULRICH J; PIUNNO PAUL A; HUDSON ROBERT H E; DAMHA MASAD; UDDIN ANDRE H
摘要:A biosensor for direct analysis of nucleic acid hybridazation by use of an optical fiber functionalized with nucleic acid molecules and fluorescence transduction is disclosed. Nucleic acid probes are immobilized onto the surface of optical fibers and undergo hybridization with complementary nucleic acids introduced into the local environment of the sensor. Hybridization events are detected by the use of fluorescent compounds which bind into nucleic acid hybrids. The invention finds uses in detection and screening of genetic disorders, viruses, and pathogenic micoorganisms. Biotechnology applications include monitoring of gene cultures and gene expression and the effectiveness (e.g. dose-response) of gene therapy pharmaceuticals. The invention includes biosensor systems in which fluorescent molecules are connected to the immobilized nucleic acid molecules. The preferred method for immobilization of nucleic acids is by in situ solid phase nucleic acid synthesis. Control of the refractive index of the immobilized nucleic acid is achieved by the support derivatization chemistry and the nucleic acid synthesis. The preferred optical fiber derivation yields a DNA coating of higher refractive index than the fiber core onto the fiber surface.

专利号:WO-2013024114-A2
优先权日:2011-08-15
标 题:Biotechnological synthesis process of omega-functionalized carbon acids and carbon acid esters from simple carbon sources