📜2-氯-4,6-二氨基-1,3,5-三嗪置于palladium On Activated Charcoal,1,2-丙二醇体系中,化学反应生成 2,4-二氨基-1,3,5-三嗪 参考文献:Foye; Weinswig,Journal Of The American Pharmaceutical Association (1912),1959,Vol. 48,P. 327 标题:Foye; Weinswig,Journal Of The American Pharmaceutical Association (1912),1959,Vol. 48,P. 327
专利信息
专利号:US-4579946-A 优先权日:1985-01-10 标 题:Process for synthesis of 2-vinyl-4,6-diamino-S-triazine 发明人:SAWA NATSUO; MASUDA TAKESHI 权利人:SHIKOKU CHEM 摘要:Disclosed is a process for the synthesis of 2-vinyl-4,6-diamino-S-triazine having the following structural formula: ##STR1## which comprises heating an imidazolyl-S-triazine compound represented by the following general formula: ##STR2## wherein R 1 stands for a hydrogen atom, a methyl group or an ethyl group, and R 2 stands for a hydrogen atom or a methyl group, or an isocyanuric acid-addition product thereof under reduced pressure in the presence of a polymerization inhibitor. n According to this process, 2-vinyl-4,6-diamino-S-triazine can be manufactured at a low cost on an industrial scale.
专利号:US-12428385-B2 优先权日:2022-05-19 标 题:Composition of a lipophilic agent for solution phase synthesis of biomolecules 发明人:LI YONGFU 权利人:LI YONGFU; BROTIDE CORE LLC 摘要:Disclosed is a lipophilic agent comprising a triazine core having lipophilic groups for organic synthesis. The lipophilic agent soluble in one system of solvent(s) wherein the lipophilic agent is participated in a chemical reaction but insoluble by adding a miscible poor solvent to change solution composition after the reaction completes. The lipophilic agent facilitates process improvement wherein practical operation only involves mixing with reactants in solution followed by precipitating with change of solution composition followed by filtering to obtain the precipitated solid, simplifying the purification by isolating the desired solid. The operation is reproducible along the progress in a multi-step synthesis, allowing pure intermediates and pure product as a solid to be rapidly obtained with ease and certainty. This invention can thus accelerate research and development of pharmaceutical biomolecules, representing a tremendous step forward for boosting productivity and greening chemical industry.
专利号:US-8759584-B2 优先权日:2007-12-14 标 题 :Synthesis of biguanidines and triazines, and biguanidino-aluminium complexes as intermediates 发明人:FORD MARK JAMES 权利人:FORD MARK JAMES; BAYER CROPSCIENCE AG 摘要:Compounds of formula (I) or salts thereof, n nin which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and Y are defined as in claim 1 , can be prepared by a process characterized in that a compound of the formula (II) or a salt thereof,n n nis reacted to a compound of the formula (III) or a salt thereof,n n nand an aluminium(III) source, optionally, in the presence of a protic additive or solvent selected from the group consisting of alcohols or amines.n n The compounds (I) are suitable to be used for the preparation of heterocyclic compounds corresponding to (I) where the group Al(X)(Y) is replaced with an optionally substituted carbon atom, or s-triazine derivatives thereof.
专利号:US-11472779-B1 优先权日:2022-05-13 标 题 :One-pot synthesis of hydrogen-bonded organic frameworks 发明人:KHAN MOHD YUSUF; KHAN ABUZAR; HELAL AASIF; YAMANI ZAIN H 权利人:UNIV KING FAHD PET & MINERALS 摘要:A hydrogen-bonded organic framework (HOF) and a method of making the HOF. The HOF has at least one amine substituted organic linker and at least one carboxylic acid-based organic linker. The HOF is prepared by dissolving the linkers separately in water and mixing the aqueous solutions, without using any organic solvents, additional catalysts, or any other reagents.
专利号:US-5087691-A 优先权日:1989-09-01 标题 :Poly-phenylated diamines and their use as polycondensation monomers in the synthesis of polyamide, poly(amide-imide), and polyimide polymers 发明人:HARRIS FRANK W 权利人:UNIV AKRON 摘要:New polyphenylated polynuclear aromatic diamines, such as 1,3-bis[4-aminophenyl]-2,3,5-triphenylbenzene, a process for their manufacture and their use as polycondensation components for the manufacture of polyamide, polyamide-imide and polyimide polymers are described. The polymers obtained with the aromatic diamines according to the invention are readily soluble, rigid-rod polymers and are distinguished by outstanding modulus, tensile compression strength, energy absorption, coefficient of expansion and electrical properties.
专利号:US-9951098-B2 优先权日:2011-03-31 标题 :Synthesis of 5-azacytidine 发明人:RAJENDIRAN CHINNAPILLAI; NAGARAJAN PERIYANDI; VENKATESWARLAU JASTI 权利人:RAJENDIRAN CHINNAPILLAI; NAGARAJAN PERIYANDI; VENKATESWARLAU JASTI; PHARMION LLC 摘要:Provided herein are processes for the preparation of 5-azacytidine, useful for treating, preventing, and/or managing diseases or conditions including cancer, disorders related to abnormal cell proliferation, hematologic disorders, and myelodysplastic syndromes (MDS), wherein 5-azacytidine is represented by the structure:
摘要:B. Roth and J.Z. Strelitz. J. Org. Chem. 34, 821 (1969). 参考文献:10.1515/znc-2001-7-814 摘要:Grossmann K, Tresch S, Plath P. Triaziflam and Diaminotriazine derivatives affect enantioselectively multiple herbicide target sites. Z Naturforsch C J Biosci. 2001 Jul;56(7-8):559–69. doi: 10.1515/znc-2001-7-814. 参考文献:10.1021/ic2003047 摘要:Duong A, Maris T, Wuest JD. Using pyridinyl-substituted diaminotriazines to bind Pd(II) and create metallotectons for engineering hydrogen-bonded crystals. Inorg Chem. 2011 Jun 20;50(12):5605–18. doi: 10.1021/ic2003047.