CAS: 4175-78-4; 2,5-Dibromothiazole

上下游产品

CAS号3034-53-5 2-溴噻唑 | CAS号3034-22-8 2-氨基-5-溴噻唑 | CAS号288-47-1 噻唑 | CAS号53715-67-6 5-溴-2-苯基-1,3-噻唑 | CAS号3704-40-3 2,5-diphenyl-1,... | CAS号223514-48-5 5-溴-2-(哌嗪-1-基)噻唑 | CAS号288-47-1 噻唑 | CAS号3034-55-7 5-溴噻唑 | CAS号904961-08-6 3-(5-溴噻唑-2-氧基)苯酚 | CAS号904961-21-3 4-(5-溴-2-氧基噻吩)苯酚 | CAS号933696-74-3 5-溴-2-(1-吡咯烷)噻唑 | CAS号54987-01-8 2,5-dithiophen-... | CAS号623588-36-3 4-(5-溴-2-噻吩)哌嗪-...

2-氨基-5-溴噻唑置于磷酸,硝酸,Sodium Nitrite,Copper(Ll) Sulfate Pentahydrate,Sodium Bromide体系中,用 水 作为反应溶剂,化学反应 1.5H,反应生成 2,5-二溴噻唑
参考文献:顺序溴化-脱溴方法合成溴化噻唑
标题:顺序溴化-脱溴方法合成溴化噻唑
摘要:溴噻唑全家族的合成已被重新研究,以更新和优化其生产.报告的物种包括2-溴噻唑,4-溴噻唑,5-溴噻唑,2,4-二溴噻唑,2,5-二溴噻唑,4,5-二溴噻唑和2,4,5-三溴噻唑,其中大多数是通过依次进行溴化和脱溴步骤.现在可以在不使用元素溴的情况下生产该完整家族,并且所提出的方法已允许首次报道该完整家族的物理和NMR光谱表征.
DOI:10.1021/acs.Joc.7B00495

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2009099200-A1
优先权日:2005-06-09
标题 :Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LI CHUN SING; RAMTOHUL YEEMAN K; HUANG ZHENG; LACHANCE NICOLAS
权利人:LI CHUN SING; RAMTOHUL YEEMAN K; HUANG ZHENG; LACHANCE NICOLAS
摘要:Azacyclohexane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-9168248-B2
优先权日:2009-02-17
标 题:Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
发明人：LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL
权利人:LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL; MERCK CANADA INC
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-8383643-B2
优先权日:2009-07-28
标题 :Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
发明人：LECLERC JEAN-PHILIPPE; LI CHUN-SING; MORADEI OSCAR MIGUEL
权利人:MERCK CANADA INC; LECLERC JEAN-PHILIPPE; LI CHUN-SING; MORADEI OSCAR MIGUEL
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-2014088114-A1
优先权日:2011-05-16
标 题:Fused bicyclic kinase inhibitors
发明人：JIN MEIZHONG; MULVIHILL MARK J; STEINIG ARNO G; WANG JING
权利人:JIN MEIZHONG; MULVIHILL MARK J; STEINIG ARNO G; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula (I), pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of MET, RON, ALK, IR, or IGF-1R. This Abstract is not limiting of the invention.

专利号:US-2007275968-A1
优先权日:2004-09-07
标 题 :Substituted Biphenyl Derivative
发明人：KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.