CAS: 33036-62-3; 4-Bromo-1-Butanol

相似化合物

60789-54-0 4457-67-4 31608-22-7

上下游产品

tetrahydrofuran Methyl 4-bromobutyrate Butane-1,4-diol 4-Bromobutyl acetate 4-Cyclohexylmercapto-butan-1-ol 4-bromobutyraldehyde 4-bromo-1-(2-tetrahydropyranyloxy)butane -phenylselenobutan-1-ol

1,4-丁二醇置于氢溴酸体系中,用 苯 作为反应溶剂,化学反应 7.0H,反应生成 4-溴-1-丁醇
参考文献:(Z)-5-癸烯基乙酸酯的烷基醚和烯醇醚类似物,萝卜蛾的信息素成分,Agrotis Segetum:探索拟议的链延长类似物的生物活性构象.
标题:(Z)-5-癸烯基乙酸酯的烷基醚和烯醇醚类似物,萝卜蛾的信息素成分,Agrotis Segetum:探索拟议的链延长类似物的生物活性构象.
摘要:为了检验先前的结论,即萝卜蛾 Agrotis Segetum 的信息素成分(z)-5-癸烯乙酸酯(1)的链延长类似物在生物活性构象中采用末端烷基链的环构象,已经合成并使用单细胞电生理学测试了一系列烷基醚和烯醇醚类似物 1 和 (Z)-5-十二碳烯乙酸酯 (2).在这些类似物中,1 的 7 和 9 位以及 In 2 的 7 和 11 位中的亚甲基已被氧原子取代,以在能量上促进链延长类似物中环构象的形成.电生理结果与分子力学(mm2 和 Mm3)计算的构象能相结合,表明链延长的醚类似物的活性降低显着小于 For2 并且这些活性降低平行于末端环形成的构象能链中的类似物.结果支持我们之前的结论,即 1 的链延长类似物的末端链在其生物活性构象中采用环构象.
DOI:10.1007/bf02033463

专利信息

专利号:US-2024294462-A1
优先权日:2023-02-15
标题:Method for the Synthesis of Ionizable Lipids Using a Doubly Alkylated Intermediate
发明人：SAADATI FARIBA; TRAN HUY; CIUFOLINI MARCO; ATMURI N D PRASAD
权利人:NANOVATION THERAPEUTICS INC
摘要:Provided herein is a method for the preparation of ionizable, cationic amino lipids using a doubly alkylated nucleophilic intermediate to produce a ketone. The ketone, or a corresponding alcohol, is subjected to one or more synthesis steps to add an ionizable moiety thereto. The method can be advantageously employed for the synthesis of unsymmetrical analogues of the above lipids that would be considerably more difficult to make by alternative strategies. The method can also be used to prepare symmetrical ionizable, cationic amino lipids with fewer steps and/or with the use of fewer hazardous chemicals than known synthesis methods.

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-8399502-B2
优先权日:2008-09-17
标 题 :Analogs of indole-3-carbinol and their use as agents against infection
发明人：JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN
权利人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN; STANFORD RES INST INT
摘要:Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

专利号:US-6849650-B2
优先权日:1998-02-27
标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-10919921-B2
优先权日:2016-05-06
标题:P-chiral phosphine ligands and use thereof for asymmetric synthesis
发明人：BOERNER ARMIN; HOLZ JENS; RUMPEL KATHARINA
权利人:BASF SE
摘要:The present invention relates to chiral compounds with two optically active phosphorus atoms, chiral transition metal catalysts which comprise these compounds as ligands, a process for preparing the P-chiral compounds and processes for asymmetric synthesis using the chiral transition metal catalysts. The present invention specifically relates to a process for preparing an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of an optically active transition metal catalyst according to the invention. Yet more specifically, the present invention relates to a process for the asymmetric hydrogenation of citral, and also a process for preparing optically active menthol.

专利号:US-7375058-B2
优先权日:2001-09-14
标 题:Herbicidal mixtures based on 3-phenyluracils
发明人：ZAGAR CYRILL; SIEVERNICH BERND; QUAKENBUSH LAURA; EVANS RICHARD R; LANDES MAX; NEWSOM LARRY J; ORTLIP CHARLES L; WITSCHEL MATTHIAS; LANDES ANDREAS
权利人:BASF AG
摘要:Herbidically active compositions, comprising: A) at least one phenyluracil compound of the formula (I); in which the variables R 1 -R 7 are as defined in the claims, and/or at least one of its agriculturally acceptable salts; and at least one further active compound, selected from B) herbicides of classes b1) to b15): b1) lipid biosynthesis inhibitors; b2) acetolactate synthase inhibitors (ALS inhibitors); b3) photosynthesis inhibitors; b4) protoporphyrinogen-IX oxidase inhibitors; b5) bleacher herbicides; b6) enolpyruvyl shikimate 3-phosphate synthase inhibitors (EPSP inhibitors); b7) glutamine synthetase inhibitors; b8) 7,8-dihydropteroate synthase inhibitors (DHP inhibitors); b9) mitose inhibitors; b10) inhibitors of the synthesis of very long chain fatty acids (VLCFA inhibitors); b11) cellulose biosynthesis inhibitors; b12) decoupler herbicides; b13) auxin herbicides; b14) auxin transport inhibitors; b15) other herbicides selected from the group consisting of benzoylprop, flamprop, flamprop-M, bromobutide, chlorflurenol, cinmethylin, methyldymron, etobenzanid, fosamine, metam, pyributicarb, oxaziclomefone, dazomet, triaziflam and methyl bromide; and safeners selected from: benoxacor, cloquintocet, cyometrinil, dichlormid, dicyclonon, dietholate, fenchlorazole, fenclorim, flurazole, fluxofenim, furilazole, isoxadifen, mefenpyr, mephenate, naplithalic anhydride, 2,2,5-trimethyl-3-(dichloroacetyl)-1,3-oxazolidine, 4-(dichloroacetyl)-1-oxa-4-azaspiro[4.5]decane and oxabetrinil, the agriculturally acceptable salts of the active compounds B and C and the agriculturally acceptable derivatives of the active compounds B and C, provided they have a carboxyl group