CAS: 31127-82-9; 3-[3-[2-[2-[2-[3-(3-Carboxy-2,4,6-Triiodoanilino)-3-Oxopropoxy]Ethoxy]Ethoxy]Ethoxy]Propanoylamino]-2,4,6-Triiodobenzoic Acid

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CAS号57741-46-5 4,7,10,13-四氧杂十六... | CAS号31127-85-2 羧酸-三聚乙二醇-羧酸 | CAS号3119-15-1 3-氨基-2,4,6-三碘苯甲酸 | CAS号31127-86-3 4,7,10,13-tetra...

📜4,7,10,13-四氧杂十六烷二酸置于氯化亚砜体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,化学反应生成 碘沙酸
参考文献:Felder; Pitre; Fumagalli,Farmaco,Edizione Scientifica,1973,Vol. 28,# 11,P. 912-924
标题:Felder; Pitre; Fumagalli,Farmaco,Edizione Scientifica,1973,Vol. 28,# 11,P. 912-924

专利信息

专利号:US-12269790-B1
优先权日:2022-04-29
标题:Process for the preparation of 2,4,6-triiodophenol derivatives
发明人：BARANYAI ZSOLT; GUIDOLIN NICOL; LAZZARI FEDERICA; UGGERI FULVIO
权利人:BRACCO IMAGING SPA
摘要:The invention relates to a process for the preparation of a 2,4,6-triiodo-phenol derivative of formula (II), which is useful as an intermediate for the synthesis of conventional X-ray contrast agents, said process comprising the tri-iodination of the correspondent phenol derivative of said 2,4,6-triiodo-phenol derivative by means of an iodinating system comprising I 2 and an oxide or a salt of an element of group 11 of the periodic table.

专利号:US-9238615-B2
优先权日:2009-04-21
标 题 :Process for the iodination of aromatic compounds
发明人：CITTERIO ATTILIO; LATTUADA LUCIANO; LEONARDI GABRIELLA; UGGERI FULVIO; VIGNALE EVELIN; VISIGALLI MASSIMO; FERRIGATO AURELIA; MELI GABRIELE; FRETTA ROBERTA; MAZZON ROBERTA
权利人:CITTERIO ATTILIO; LATTUADA LUCIANO; LEONARDI GABRIELLA; UGGERI FULVIO; VIGNALE EVELIN; VISIGALLI MASSIMO; FERRIGATO AURELIA; MELI GABRIELE; FRETTA ROBERTA; MAZZON ROBERTA; BRACCO IMAGING SPA
摘要:The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.

专利号:US-9193659-B2
优先权日:2008-02-20
标 题 :Process for the iodination of aromatic compounds
发明人：GIOVENZANA GIOVANNI BATTISTA; CAVALLOTTI CAMILLA; LATTUADA LUCIANO; UGGERI FULVIO
权利人:GIOVENZANA GIOVANNI BATTISTA; CAVALLOTTI CAMILLA; LATTUADA LUCIANO; UGGERI FULVIO; BRACCO IMAGING SPA
摘要:The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2, 4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3, 5- disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7).

专利号:US-2016138027-A1
优先权日:2013-03-14
标 题:Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1)
发明人：GAN LIN; MEYER TOBIAS
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods for treating diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mTORC1) are disclosed. The invention is based in part on the discovery that protein mediator of amino acid signaling to mTOR (MORTOR) is involved in amino acid-induced translocation of mTORC1 to lysosomes where MORTOR forms a signaling complex with mTORC1, Ragulator, and Rag GTPases, which controls protein synthesis. In particular, the invention relates to the use of antagonists of MORTOR for treating diseases and conditions associated with dysregulation of mTORC1. Downregulation of expression of MORTOR by RNA interference has been shown to reduce cell proliferation of cancerous cells and may be useful for treating cancer.