CAS: 30483-75-1; 4-(4-Bromophenyl)Morpholine

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CAS号92-53-5 4-苯基吗啉 | CAS号110-91-8 吗啉 | CAS号589-87-7 对溴碘苯 | CAS号321970-34-7 1,1,2,2,3,3,4,4... | CAS号106-37-6 对二溴苯 | CAS号5765-65-1 苯甲酸吗啉 | CAS号7519-94-0 2,4,6-tris(4-br... | CAS号66107-30-0 4-溴苯基三氟甲磺酸酯 | CAS号183677-71-6 4-溴苯硼酸新戊二醇酯 | CAS号947515-73-3 (4-bromophenyl)... | CAS号568577-88-8 4-(4-吗啉基)苯硼酸频哪酯 | CAS号10282-31-2 4-(4-氰苯基)吗啉 | CAS号186498-02-2 4-吗啉苯硼酸 | CAS号88799-18-2 4-(4-bromopheny... | CAS号634905-12-7 4-(4-溴苯基)吗啉-3-酮

📜4-苯基吗啉置于tert-Butylammonium Hexafluorophosphate(V),Potassium Carbonate,3-溴丙炔体系中,用 N-甲基吡咯烷酮,水 作为反应溶剂,化学反应 12.0H,以91%的收率获得产物4-(4-溴苯基)吗啉
参考文献:使用炔丙基溴作为前所未有的溴源的 N,N-二取代苯胺的无金属电化学区域选择性芳族 C-H 溴化
标题:使用炔丙基溴作为前所未有的溴源的 N,N-二取代苯胺的无金属电化学区域选择性芳族 C-H 溴化
摘要:官能团的来源一直是化学合成中的重要因素.本文公开了一种在电化学条件下使用炔丙基溴作为非常规溴源的高区域选择性单溴化n,N-二取代苯胺的新方法.与其他溴源不同,它既不需要任何极化,也不需要任何活化剂.该反应在室温下顺利进行,无需使用任何金属催化剂或溴化物盐.对于未取代的苯胺,观测到区域选择性对位溴化,而间位和对位取代的苯胺均经历主要的邻位溴化,导致相应的n,N-二取代溴苯胺产率高.通过支持 B3Lyp/6-31G Dft 计算描述了合理的机制,以解释相对能量驱动的过程.
DOI:10.1016/j.Tet.2022.132902

专利信息

专利号:US-4178447-A
优先权日:1977-09-23
标 题:Novel synthesis of 3,3-substituted dihydrobenzisothiazole-1,1-dioxides and -2,3-dihydronaphtho-1,2-thiazine-1,1-dioxides
发明人：BORROR ALAN L; FOLEY JAMES W; KAMPE MARCIS M; LEE JOHN W JR
权利人:POLAROID CORP
摘要:This invention relates to a method of synthesizing certain 3-(carbocyclic aryl)-3-(4'-OP-carbocyclic aryl)-2,3-dihydrobenz[d]isothiazole-1,1-dioxides (and -2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxides) by reacting (a) a 4-OP-carbocyclic aryllithium compound wherein P is a protecting group and (b) a 3-(carbocyclic aryl)benz[d]isothiazole-1,1-dioxide wherein said 3-(carbocyclic aryl) moiety is other than a 3-(4'-OP-carbocyclic aryl) moiety to give (c) the corresponding 3-carbocyclic aryl)-3-(4'-OP-carbocyclic aryl)-2,3-dihydrobenz[d]isothiazole-1,1-dioxide. The -2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxides are prepared in the same manner by reacting a 3-(carbocyclic aryl)naphtho[1,8-de]-1,2-thiazine-1,1-dioxide with said 4'-OP-carbocyclic aryllithium compound. n In a further embodiment, the compounds synthesized according to the foregoing method are reacted with a carboxylic acid halide to give the corresponding 2-carbonyl-substituted 2,3-dihydrobenz[d]isothiazole-1,1-dioxide (or -2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxides) followed by removing the protecting group, P, with weak acid to yield certain phenol and 1-naphthol sulfam(na)phthaleins useful, e.g., as optical filter agents and filter agent precursors in photography.

专利号:US-4311839-A
优先权日:1977-09-23
标题 :Benzisothiazole and naphtho-1,2-thiazine compounds
发明人：BORROR ALAN L; CINCOTTA LOUIS; FOLEY JAMES W; KAMPE MARCIS M
权利人:POLAROID CORP
摘要:In one aspect, this invention relates to a method of synthesizing certain 3-(4'-OP-carbocyclic aryl)-3-(carbocyclic aryl)-2,3-dihydrobenz[d]isothiazole-1,1-dioxides (and -2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxides) by reacting (a) a 3-(4'-OP-carbocyclic aryl)-benz[d]isothiazole-1,1-dioxide wherein P is a protecting group or a 3-(4'-OP-carbocyclic aryl)-naphtho[1,8-de]-1,2-thiazine-1,1-dioxide wherein P is a protecting group and (b) a carbocyclic aryllithium compound to give (c) the corresponding 3-(4'-OP-carbocyclic aryl)-3-(carbocyclic aryl)-2,3-dihydrobenz[d]-isothiazole-1,1-dioxide or the corresponding 3-(4'-OP-carbocyclic aryl)-3-(carbocyclic aryl)-2,3-dihydronaphtho-[1,8-de]-1,2-thiazine-1,1-dioxide. In another aspect, the present invention relates to the 3,3-disubstituted-2,3-dihydrobenz[d]isothiazole-1,1-dioxides and the 3,3-disubstituted-2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxides produced by the above-described method provided the 3,3 substituents are different, which compounds are useful in the synthesis of phenol and 1-naphthol sulfam(na)phthaleins employed, for example, as photographic optical filter agents and filter agent precursors.

专利号:US-7175871-B2
优先权日:2002-07-15
标题:Acyclic enol ethers, isomers thereof, organoleptic uses thereof and processes for preparing same
发明人：MOOKHERJEE BRAJA DULAL; NARULA ANUBHAV P S; PATEL SUBHA M; ARRUDA EDWARD MARK; MERRITT PATRICK M
权利人:INT FLAVORS & FRAGRANCES INC
摘要:Described are synthetically produced substantially pure enol ether compositions which are cis and/or trans isomers of enol ethers having the structures: n nwherein R 1 is C 4 –C 10 straight chain alkyl or C 9 8-alkenyl; and wherein R 2 is C 1 –C 4 alkyl, C 3 –C 4 2-alkenyl, C 4 3-alkenyl or C 10 non-allenic alkadienyl and uses thereof in imparting, augmenting or enhancing the aroma and/or taste of a consumable material such as a perfume composition, a cologne, a perfumed article such as a soap, cosmetic, hair preparation or detergent, a foodstuff, a chewing gum or an alcoholic or non-alcoholic beverage such as a carbonated beverage or fruit liquer. Also described is a process for synthesis of such enol ethers by means of (i) first forming an acetal having the structure:n R 1 —CH 2 —CH(OR 2 ) 2 n(ii) then carrying out a thermal decomposition reaction at pH<7 and then (iii) fractionally distilling the resulting reaction product to provide the enol ether.

专利号:US-4139704-A
优先权日:1977-09-23
标 题 :Cyclic amino containing benzisothiazoles
发明人：BORROR ALAN L; FOLEY JAMES W; LEE JR JOHN W
权利人:POLAROID CORP
摘要:This invention relates to 3-(phenyl/naphthyl)benz[d]isothiazole-1,1-dioxides wherein the phenyl or naphthyl substituent possesses an N-heterocyclic moiety in the para position. These compounds are useful as intermediates in the synthesis of certain 3,3-disubstituted-2,3-dihydrobenz[d]isothiazole-1,1-dioxide dyes which find utility as, for example, photographic optical filter agents and filter agent precursors.

专利号:CA-1110237-A
优先权日:1977-09-23
标题:Synthesis of new sulfamphthaleins

专利号:US-7648986-B2
优先权日:2002-01-10
标题:Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors
发明人：NAGARATHNAM DHANAPALAN; KHIRE UDAY; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; WANG CHUNGUANG; HART BARRY; WEBER OLAF; LYNCH MARK; ZHANG LEI; WANG LEI
权利人:BAYER HEALTHCARE LLC
摘要:Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.