CAS: 30391-89-0; 2-Amino-N-Isopropylbenzamide

上下游产品

isatoic anhydride isopropylamine anthranilic acid Aethyl-isopropylphosphoramid°Chloridat2,3-dihydro-3-isopropyl-2-phenyl-4(1H)-quinazolinone 3-isopropyl-2-phenyl-quinazoline-4(3H)-one Bentazon 2-[(2,5-dichloro-4-pyrimidinyl)amino]-N-(1-methylethyl)benzamide

📜邻硝基苯甲酸置于甲醇,氯化亚砜,铁粉,氯化铵体系中,用 水 作为反应溶剂,化学反应 7.0H,反应生成 邻氨基苯甲酸异丙基胺
参考文献:Design And Synthesis Of Diphenylpyrimidine Derivatives (Dppys) As Potential Dual Egfr T790M And Fak Inhibitors Against A Diverse Range Of Cancer Cell Lines
标题:Design And Synthesis Of Diphenylpyrimidine Derivatives (Dppys) As Potential Dual Egfr T790M And Fak Inhibitors Against A Diverse Range Of Cancer Cell Lines
摘要:A New Class Of Pyrimidine Derivatives Were Designed And Synthesized As Potential Dual Fak And Egfr(T79)(0M) Inhibitors Using A Fragment-Based Drug Design Strategy. This Effort Led To The Identification Of The Two Most Active Inhibitors,Namely 9A And 9F,Against Both Fak (Ic50,= 1.03 And 3.05 Nm,Respectively) And Egfr(T79)(0M) (Ic50 = 3.89 And 7.13 Nm,Respectively) Kinase Activity. Moreover,Most Of These Compounds Also Exhibited Strong Antiproliferative Activity Against The Three Evaluated Fak-Overexpressing Pancreatic Cancer (Pc) Cells (Aspc-1,Bxpc-3,Panc-1) And Two Drug-Resistant Cancer Cell Lines (Breast Cancer Mcf-7/adr Cells And Lung Cancer H1975 Cells) At Concentrations Lower Than 6.936 Mu M. In Addition,9A Was Also Effective In The In Vivo Assessment Conducted In A Fak-Driven Human Aspc-1 Cell Xenograft Mouse Model. Overall,This Study Offers A New Insight Into The Treatment Of Hard To Treat Cancers.
DOI:10.1016/j.Bioorg.2019.103408

专利信息

专利号:CN-114560784-A
优先权日:2021-12-08
标 题:A kind of method for continuous synthesis of bentazone intermediate anthranilic acid isopropionamide

专利号:CN-101967109-B
优先权日:2010-09-01
标题:Synthesis method of bentazone midbody 2-amino-N-isopropylbenzamide

专利号:CN-101967109-A
优先权日:2010-09-01
标 题:Synthesis method of bentazone midbody 2-amino-N-isopropylbenzamide