CAS: 29027-20-1; 3-Chloro-5-Methylaniline

上下游产品

CAS号16582-38-0 3-氯-5-硝基甲苯 | CAS号5465-33-8 2-氯-4-甲基-6-硝基苯胺 | CAS号89-62-3 4-甲基-2-硝基苯胺 | CAS号618-61-1 3-甲基-5-硝基苯胺 | CAS号618-85-9 3,5-二硝基甲苯 | CAS号116632-43-0 1-氯-3-碘-5-甲基苯

📜3,5-二硝基甲苯置于盐酸,Ammonium Polysulphide,Tin(Ll) Chloride体系中,化学反应生成3-氯-5-甲基苯胺
参考文献:氯化吡咯与一些取代的苯胺反应的动力学.第5部分
标题:氯化吡咯与一些取代的苯胺反应的动力学.第5部分
摘要:已测量了氯化吡咯与以下取代的苯胺在乙腈中的反应的arrhenius参数:3-氨基和3-甲基苯胺,3-氨基-5-硝基苯胺,3-氟-5-甲基磺酰基苯胺,3-X-5-甲基苯胺(x = No 2,Ome,Ch 3,F,Cl,Br或i)和3,5-X 2-苯胺(x = F,Cl,Br或i).现已研究了总共33个3,5-二取代苯胺对取代基对活化自由能的可加性的影响,并且表明,除3-氨基-5-硝基苯胺外,该假说重现了实验速率常数.在2分之一的范围内,当使用更严格的可加性标准时,对于某些情况下出现的偏差提出了合理化建议.
Doi:10.1039/p29800000829

专利信息

专利号:US-6828466-B2
优先权日:2002-07-19
标题:Process for the synthesis of phenols from arenes
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
权利人:UNIV MICHIGAN STATE
摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

专利号:US-2004030197-A1
优先权日:2002-07-19
标 题 :Process for the synthesis of phenols from arenes

专利号:US-8450342-B2
优先权日:2007-09-12
标题:Perharidines as CDK inhibitors
发明人：MEIJER LAURENT; BETTAYEB KARIMA; GALONS HERVE; DEMANGE LUC; OUMATA NASSIMA
权利人:MEIJER LAURENT; BETTAYEB KARIMA; GALONS HERVE; DEMANGE LUC; OUMATA NASSIMA; CENTRE NAT RECH SCIENT; UNIV RENNES; UNIV PARIS DESCARTES
摘要:The invention relates to trisubstituted or tetrasubstituted imidazo[4,5b]pyridines, to their uses as well as to a process for manufacturing them. n The compounds of the invention are imidazo[4,5b]pyridines. n The first general synthesis of 3,5,7 imidazo[4,5b]pyridines is disclosed in the description. n The invention founds application, in particular, in the pharmaceutical field.

专利号:WO-2022262686-A1
优先权日:2021-06-13
标题 :Kras g12d inhibitors
发明人：HAN YING; LI DAPENG; WANG TONG
权利人:JINGRUI BIOPHARMA CO LTD
摘要:Disclosed are novel compounds which are KRAS G12D inhibitors, their synthesis and their use for treating diseases or conditions, such as cancer, and in particular for inhibiting the activity of KRAS G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.