CAS: 24880-43-1; (-)-Mesembrine

上下游产品

Mesembrine 6023-73-0
(-)-Mesembranol 23544-42-5
(+)-(3As,7R,7As)-[3A-(3,4-Dimethoxyphenyl)-6,6-(2,2-Dimethylpropylenedioxy)-1-Methyloctahydroindol-7-Yl]Methanol 187850-43-7
δ7 Mesembrenone 35714-44-4
(+)-[(3As,7R,7As)-3A-(3,4-Dimethoxyphenyl)-6,6-(2,2-Dimethylpropylenedioxy)Octahydroindol-7-Yl]Methanol 187850-40-4
(+)-(3As,7As)-3A-(3,4-Dimethoxyphenyl)-1-Methyl-6-[(2,2-Dimethyl-3-Hydroxypropyl)Oxy]-7-Formyl-2,3,3A,4,5,7A-Hexahydro-6H-Indole 187850-45-9
[(3R,3As,7As)-1-Benzhydryl-3A-(3,4-Dimethoxyphenyl)-3,6,7,7A-Tetrahydro-2H-Indol-3-Yl]Methanol 189363-92-6
(S)-2-(1-(3,4-二甲氧基苯基)-2-氧代环己基)-N-甲基乙酰胺 2-[(1S)-1-(3,4-Dimethoxyphenyl)-2-Oxocyclohexyl]-N-Methylacetamide 216005-88-8 [(3R,3As,7As)-1-Benzhydryl-3A-(3,4-Dimethoxyphenyl)-3,6,7,7A-Tetrahydro-2H-Indol-3-Yl]Methoxy-Tert-Butyl-Dimethylsilane [(3R,3As,7As)-3A-(3,4-Dimethoxyphenyl)-1-(4-Methylphenyl)Sulfonyl-6-Oxo-2,3,4,5,7,7A-Hexahydroindol-3-Yl]Methyl Methyl Carbonate

📜3,4-二甲氧基苯乙腈置于copper(L) Chloride,Palladium Dichloride 盐酸,氢氧化钾,Sodium Tetrahydroborate,氧气,Lithium,Lithium Diisopropyl Amide体系中,用 四氢呋喃,乙醇,氨,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 172.0H,反应生成松叶菊碱
参考文献:以(d)-甘露醇为手性模板对天然膜的对映选择性合成,对芳科植物生物碱的对映选择性合成的模型研究
标题:以(d)-甘露醇为手性模板对天然膜的对映选择性合成,对芳科植物生物碱的对映选择性合成的模型研究
摘要:使用(d)-甘露糖醇已经实现了对映体(-)-Membrine(1)的对映选择性合成,目的是开发金缕梅科生物碱的对映体选择性合成.
Doi:10.1016/s0040-4039(01)93019-9

专利信息

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2025125811-A1
优先权日:2023-12-12
标题:Heterocyclic compounds and their use for the treatment of neurological disorders
发明人：PLOWRIGHT ALLEYN THOMAS; PFEIFFER THOMAS; MÄRCHER-RØRSTED EMIL; DUCKWORTH EDWARD JOSEPH
权利人:ONTRACK THERAPEUTICS LTD
摘要:The present invention relates to novel synthetic compounds of Formula (I) and (II) related to naturally occurring flavonoids such as 7,8-dihydroxyflavone (7,8-DHF). The invention further relates to the method of synthesis, the use of these compounds as research tools and their use as pharmaceuticals.

专利号:US-2014255341-A1
优先权日:2011-07-22
标题:Tumor Selective Chemokine Modulation
发明人：KALINSKI PAWEL; MUTHUSWAMY RAVIKUMAR
权利人:KALINSKI PAWEL; MUTHUSWAMY RAVIKUMAR
摘要:Therapies effective for the treatment and prevention of cancer and other diseases are disclosed. These methods include the administration of therapeutically effective amounts of agents that increase the local production of effector cell-attracting chemokines within tumor lesions, with concomitant suppression of local production of undesirable chemokines that attract regulatory T(reg) cells. These methods include administering to the subject therapeutically effective amounts of a Toll-like receptor (TLR) agonist or other activator of NF-KB pathway in combination with a blocker of prostaglandin synthesis or a blocker of prostaglandin signaling, in combination with a type-1 interferon, or in combination with both a blocker of prostaglandin synthesis or signaling and with a type-1 interferon. Alternatively, the methods derived from the same paradigms, but aimed to treat or prevent autoimmune disease, chronic inflammatory disease, transplant rejection or GvR, include the combination of a Toll-like receptor (TLR) agonist in combination with a prostaglandin or other cAMP-activator.

专利号:US-9550795-B2
优先权日:2011-08-31
标 题:Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS
权利人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2012172449-A1
优先权日:2011-06-13
标题:Lactams as beta secretase inhibitors
发明人：BRODNEY MICHAEL AARON
权利人:PFIZER; BRODNEY MICHAEL AARON
摘要:Compound and pharmaceutically acceptable salts of the compound are disclosed, wherein the compound has the structure (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. The compound of formula I is useful as beta secretase inhibitor for use in the treatment of Alzheimer's and other neurodegenerative and/or neurological disorders.

专利号:US-2016229847-A1
优先权日:2013-10-04
标 题:Novel bicyclic pyridinones as gamma-secretase modulators
发明人：PETTERSSON MARTIN YOUNGJIN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; JOHNSON DOUGLAS SCOTT; KAUFFMAN GREGORY WAYNE; O'DONNELL CHRISTOPHER WILLIAM; PATEL NANDINI CHATURBHAI; STEPAN ANTONIA FRIEDERIKE; STIFF CORY MICHAEL; SUBRAMANYAM CHAKRAPANI; TRAN TUAN PHONG; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula II as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.