CAS: 23244-88-4; 6-Hydroxyindazole

该化合物是一个有机化合物,其特性为异氮核心,由含有两个氮原子的五人环组成,该化合物在异氮环的6个位置上具有氢氧基(-OH),有助于将其分类为异氮衍生物,通常是白色到非白固体,在极地溶剂中溶解,反映其因存在氢氧气而具有结合氢的能力,该化合物在各个领域都有意义,包括医药化学领域,因为其潜在的生物活动可能包括反炎和抗癌特性,其再活动可能受到现有功能组的影响,使其成为有机合成的多用途构件.应参考安全数据,以便处理与任何化学物质一样,确保采取适当的预防措施.

英文名称6-Hydroxyindazole
中文名称6-羟基吲唑
IUPAC名称1H-indazol-6-ol
其它别名6-Hydroxy-1H-Indazole; Indazol-6-Ol; 6-Isoindazolol; Ethanaminium, N-[9-(2-Carboxyphenyl)-6-(Diethylamino)-3H-Xanthen-3-Ylidene]-N-Ethyl-, Chloride; Indazole, 6-Hydroxy-
CAS编号23244-88-4
MFCD编号:MFCD00022788
EINECS号:245-519-5
分子式:C7H6N2O
分子量:134.14
产品CID: 1174078
产品分类有机原料→分子砌块→芳杂环类化合物→吲唑类化合物

相似结构搜索
InChIKey: NUYZVDBIVNOTSC-UHFFFAOYSA-N
InChI=1S/C7H6N2O/c10-6-2-1-5-4-8-9-7(5)3-6/h1-4,10H,(H,8,9)…
计算化学: 氢键受体数1.0氢键供体数2.0可旋转键数0.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
警示词Warning(警告)
危险描述H302 |吞咽有害.
防范说明P264-P270-P330-P501
危险品标志Xn
安全声明26-36:-
危险类别码22
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 6-Hydroxyindazole 主要起始原料 6-Aminoindazole
(文献来源)合成步骤主要原料 6-Aminoindazole

2-氨基-4-硝基甲苯置于乙醇,硫酸,硫化氢,氨,水,Sodium Nitrite体系中,化学反应生成6-羟基吲唑
参考文献:Witt; Noelting; Grandmougin,Chemische Berichte,1890,Vol. 23,P. 3642
标题:Witt; Noelting; Grandmougin,Chemische Berichte,1890,Vol. 23,P. 3642

海关参考信息

2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸
2905199090-其他饱和一元醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2008033184-A1
优先权日:2006-08-01
标题 :Intermediates and methods for serotonergic agonist synthesis
发明人：DELGADO PETE; DEAN W DENNIS; CONROW RAYMOND E
权利人:ALCON MFG LTD
摘要:Disclosed is a method of making a 1-alkylindazole comprising reacting a 1-acylindazole with a first reducing agent, and contacting the resulting mixture with an acid anhydride or acyl halide, and with pyridine or a 4-dialkylaminopyridine or a combination of pyridine and a 4-dialkylaminopyridine, to form a hemiaminal ester and reacting the hemiaminal ester with a second reducing agent to form a 1-alkylindazole. Also disclosed are intermediates for the synthesis of 1-alkylindazoles.

专利号:US-9951088-B2
优先权日:2012-05-09
标题 :D2 receptor modulators and methods of use thereof in the treatment of diseases and disorders
发明人：JONES PHILIP G; LEW ROBERT; SPEAR KERRY L; XIE LINGHONG
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and neurological disorders, including, but not limited to, e.g., psychosis, schizophrenia, depression, movement disorders, and Parkinson's disease.